Safety and Immunogenicity of a Newcastle Disease Virus Vector-Based SARS-CoV-2 Vaccine Candidate, AVX/COVID-12-HEXAPRO (Patria), in PigsResearch Article Published on 2021-09-212022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition Administered Adverse reaction Antigen approved B.1.1.7 B.1.351 candidate Combination coronavirus coronavirus disease coronavirus vaccine COVID-19 dose Effectiveness Efficacy expressing HexaPro Immunity immunogenic immunogenicity include induce intramuscular intranasal intranasally mucosal NDV newcastle disease virus P.1 pig pig model PIGS prefusion conformation proline substitution prolines reactivity responses Safe Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine Serum neutralizing antibody spike spike variant tested the vaccine Vaccine [DOI] 10.1128/mBio.01908-21 PMC 바로가기 [Article Type] Research Article
Acute Myopericarditis after COVID-19 Vaccine in TeenagersCase Report Published on 2021-09-202022-11-01 Journal: Case Reports in Cardiology [Category] COVID-19, [키워드] acute coronary syndromes appear Care Chest CT chest pain Clinical course coronavirus disease coronavirus vaccine COVID-19 COVID-19 vaccine Diagnosis discharge Echocardiogram elevated elevations fatigue Fever Follow-up full recovery headache Health help invasive knowledge management medication myocarditis Myopericarditis normalized Pain pathophysiology Patient presenting receiving second dose Symptom symptomatic Symptoms vaccination Vaccinations [DOI] 10.1155/2021/8268755 PMC 바로가기 [Article Type] Case Report
Characterization of Vaccine Tweets During the Early Stage of the COVID-19 Outbreak in the United States: Topic Modeling AnalysisOriginal Paper Published on 2021-09-142022-10-30 Journal: Jmir Infodemiology [Category] COVID-19, [키워드] allocation Analysis analyzed association change characterization characterized concern contributed coronavirus coronavirus vaccine Coronavirus vaccines COVID-19 COVID-19 outbreak COVID-19 pandemic Critical database demonstrated development early stage effective Efficacy effort emotion event had more identify implication infectious disease outbreak infoveillance Latent lowest media Meltwater Metadata Metrics modeling negative negative emotion New objective outbreak prayer proportion provided public health Result Safe similarities social media Spread Stage tested the disease the United State Topic topic modeling Vaccine Vaccine development Vaccines venting [DOI] 10.2196/25636 PMC 바로가기 [Article Type] Original Paper
Skin Adverse Reactions to Novel Messenger RNA Coronavirus Vaccination: A Case SeriesBrief Report Published on 2021-08-272022-11-01 Journal: Diseases [Category] COVID-19, [키워드] Adverse Adverse reaction Adverse reactions age anaphylaxis authority characterized contribute coronavirus vaccine corticosteroid treatment COVID-19 COVID-19 vaccination delayed skin reactions dose edema effective erythematous facial FIVE Guidance Health care worker high risk individual injection Italian Italy lesions messenger Messenger RNA Mild novel novel messenger RNA coronavirus vaccine Nurses observation period occur occurred Patient patients pharmacovigilance physician preventive measure pruritus Rash reaction reduce mortality reported RNA Safe Sardinia second dose Sery skin skin adverse reactions Spontaneous Spread Treatment vaccination Vaccine were excluded widespread women [DOI] 10.3390/diseases9030058 PMC 바로가기 [Article Type] Brief Report
Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in miceN7-메틸트랜스퍼라제 활성이 결핍된 약독화 코로나바이러스 생백신은 마우스에서 체액성 및 세포성 면역 반응을 모두 유도합니다Original Article Published on 2021-08-182022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral approach Attenuated vaccines cap structure caused CD4 CD8 Cell culture Cellular immune response conserved coronavirus coronavirus vaccine Coronavirus vaccines Coronaviruses CoV COVID-19 pandemic CoVs Economy effective function guanine Health hosts humans humoral humoral immune response immune responses immunization induce infect Infection involved Live attenuated vaccine Live attenuated vaccines livestock MHV MHV-A59 mice murine hepatitis virus mutant N7-Methyltransferase nsp14 Protein provide replication efficiency respiratory RNA RNA virus robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus single dose T cell T cell responses the cell Treatment Vaccine variety Viral Viral RNA virus viruses wild-type [DOI] 10.1080/22221751.2021.1964385 PMC 바로가기 [Article Type] Original Article
Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective ReviewReview Published on 2021-07-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D structure acute respiratory syndrome antigenic epitope bioinformatics bioinformatics resources caused computational tool contagious coronavirus coronavirus strain coronavirus vaccine COVID-19 database death disease effective effort epitope experimental validation function Genome sequencing genomic globe immune response immunoinformatics in viral pandemic pathogen platform Protein researcher resource resources review SARS-CoV-2 Stage target the vaccine Vaccine vaccine construct valuable resource [DOI] 10.3390/vaccines9080812 PMC 바로가기 [Article Type] Review
Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design심층 돌연변이 스캐닝 및 구조 기반 설계를 사용한 SARS-CoV-2 스파이크 수용체 결합 도메인의 안정화Immunology Published on 2021-06-292022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 비임상, 진단, [키워드] aggregation antigen stabilization antigenicity binding pocket breath candidate Cavity Characteristics clinical trial computational protein design coronavirus coronavirus vaccine deep deep mutational scanning demonstrated displaying effective evaluated expressed highlight immunogen IMPROVE lead linoleic acid Mutation nanoparticle phase presenting preserved Protein RBD Receptor-binding domain reported robust SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines scalability scanning Screening selected shown spike Spike protein stability the RBD the receptor-binding domain the SARS-CoV-2 thermal stability utility Vaccine vaccine candidate vaccine candidates Vaccine design variant wild-type [DOI] 10.3389/fimmu.2021.710263 PMC 바로가기 [Article Type] Immunology
Subacute Thyroiditis After Receiving the Adenovirus-Vectored Vaccine for Coronavirus Disease (COVID-19)Endocrinology/Diabetes/Metabolism Published on 2021-06-292022-10-31 Journal: Cureus [Category] COVID-19, [키워드] adenovirus-vector Blood Case report contribute coronavirus coronavirus disease coronavirus vaccine COVID 19 COVID-19 COVID-19 vaccination COVID-19 vaccine demonstrated dysfunction effective effective vaccine female had no Hypothyroid Immunity immunogenic initial introduced Neck pain overt hypothyroidism pandemic pathway Patient raise receiving Subacute Subacute thyroiditis Thyroid Thyroiditis Vaccine [DOI] 10.7759/cureus.16045 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism
Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjectsCOVID-19+ 대상에서 교차 중화 코로나바이러스 항체의 분리 및 특성화Article Published on 2021-06-222022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 진단, [키워드] Abstract ACE2 receptor anti-RBD anti-S2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies antibodies antibody B.1.351 B.1.351 variant binding caused coronavirus coronavirus vaccine cross-neutralize cross-neutralizing cross-neutralizing antibody CV3-25 disease epitope Epitopes human coronavirus identify immunogen immunogens K18-hACE mAb mice monoclonal antibodies mouse mutant N-terminal domain NAb neutralization neutralization potency neutralize neutralized Neutralizing Neutralizing antibodies neutralizing antibody NTD Pandemics Patient patients Prevent Protective protective effect RBD Receptor-binding domain recognize regulate reveal S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 RBD specificity subject target the receptor-binding domain Transgenic mouse Vaccines widespread [DOI] 10.1016/j.celrep.2021.109353 PMC 바로가기 [Article Type] Article
Attitudes and Acceptance of COVID-19 Vaccination Among Nurses and Midwives in Cyprus: A Cross-Sectional SurveyPublic Health Published on 2021-06-162022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] acceptance affected Attitude Characteristics conducted coronavirus vaccine Coverage COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cross-sectional survey Cyprus Data collection determine Factor females group Health healthcare worker highlight individual Intention mass vaccination median age Nurse Nurses participant Probability professionals proportion question questionnaire receive receiving reported Responder seasonal flu Side effects socio-demographic survey the vaccine vaccination Vaccination refusal Vaccine Vaccines [DOI] 10.3389/fpubh.2021.656138 PMC 바로가기 [Article Type] Public Health