Middle East Respiratory Syndrome Vaccine Candidates: Cautious OptimismReview Published on 2019-01-172022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] animal model animal models approach clinical trials coronavirus spike glycoprotein Coronavirus vaccines correlates of immunity Efficacy generate highlight MERS-CoV Middle East Middle East respiratory syndrome Coronavirus respiratory respiratory syndrome coronavirus severe acute respiratory syndrome Coronavirus shown Vaccine vaccine platforms variety [DOI] 10.3390/v11010074 PMC 바로가기 [Article Type] Review
Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus VaccinesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antigen-presenting cell Author Cell culture Cell-mediated immunity cellular Cellular immune response coding sequence coronavirus Coronavirus infection coronavirus vaccine Coronavirus vaccines Coronaviruses Culture deleting dendritic cell disease elicited Factors Gene Expression genetics Heterologous homolog homologous IFN immune responses implication in vitro in vivo interfere long-lasting low dose macrophages Major MHV mice mouse hepatitis virus murine model mutant mutant virus non-structural protein pathogenicity plasmacytoid dendritic cells prevention Protective protective immune response Protein provide recombinant vaccine reduced replicate Replication replication-competent virus restored retained SARS-coronavirus sequence Spread T cell response tissue Type I IFN type I interferon vaccination Vaccine viral disease viral pathogenicity viral pathogens virus wild-type [DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article