Serum hydroxybutyrate dehydrogenase and COVID-19 severity and mortality: a systematic review and meta-analysis with meta-regressionArticle Published on 2022-11-012022-11-15 Journal: Clinical and experimental medicine [Category] 바이오마커, [키워드] 95% CI Admission alteration Analysis Biomarker certainty of evidence Concentration conducted coronavirus disease COVID-19 COVID-19 patients COVID-19 severity disease severity effect size Egger estimates heterogeneity hospitalized COVID-19 patient hydroxybutyrate hydroxybutyrate dehydrogenase Inflammation Injury Liver damage magnitude marker Meta-analysis meta-regression moderate Mortality Myocardial myocardial injury non-specific non-survivor Patient performed renal renal function reported risk stratification searched Sepsis serum severity significantly significantly higher SMD standardized mean difference survival survivor systematic review tissue damage Web of Science [DOI] 10.1007/s10238-021-00777-x PMC 바로가기
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity BiomarkersResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] 바이오마커, 임상, 진단, 치료기술, [키워드] addition approach Bioinformatic Bioinformatics analysis Biomarker Biomarkers candidate Compound conserved COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity Cytokine storm Cytokines dataset datasets disease severity enriched biological processe extreme highlight Identified identify IL6 immunological reaction include Inflammatory biomarker Inflammatory response interleukin 6 Isolation neurological Patient physiological system Prognosis Prognostic markers progression Protein proteomics regulator rising robust screening methods severity Therapeutic approach treating COVID-19 Treatment upstream validation study [DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
SARS-CoV-2-Naïve Korean Children and Adolescents Hospitalized With COVID-19 in 2021Article Published on 2022-10-312022-11-16 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome adjusted odds ratio Adolescent Affect children clinical manifestation conditions coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity Critical evaluated had no hospital Hospitalization Hospitalized Illness severity Isolation Korean less Medical conditions medical need Mild moderate multicenter obesity outcome Patient Pneumonia proportion respiratory Retrospective study risk risk factor SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity South Korea vaccination against COVID-19 variant with COVID-19 [DOI] 10.3346/jkms.2022.37.e303 PMC 바로가기
Network Analysis for Uncovering the Relationship between Host Response and Clinical Factors to Virus Pathogen: Lessons from SARS-CoV-2Article Published on 2022-10-312023-07-10 Journal: Viruses [Category] COVID19(2023년), [키워드] COVID-19 severity Data visualisation IgM and IgG levels minimal immune signature Multivariate data analysis patient similarity network. [DOI] 10.3390/v14112422 PMC 바로가기
An explainable model of host genetic interactions linked to COVID-19 severityArticle Published on 2022-10-262022-11-16 Journal: Communications Biology [Category] 변종, 유전자 메커니즘, [키워드] age and gender Analysis classifiers Cohort contributing to covariates COVID-19 COVID-19 severity dataset Factor Features Follow-up Genetic GWAS high accuracy highest Host identify immune pathways immune system increased risk Inflammatory Interaction Italian patients MCC molecular mechanism offer outcome Patient phenotypic predict predicted Predictive screened several variant Severe COVID-19 Infection severity Signaling significantly Stratification stratified Support tested therapeutic intervention Thoracic variant viral infection WES with COVID-19 [DOI] 10.1038/s42003-022-04073-6 PMC 바로가기
Does vitamin D supplementation reduce COVID-19 severity?: a systematic reviewArticle Published on 2022-10-252022-11-16 Journal: QJM: An International Journal of Medicine [Category] meta-analysis, [키워드] Covid patients COVID-19 COVID-19 severity effective Efficacy eligible Evidence Google heterogeneity heterogeneous hospitalized COVID-19 initial screening intensive care lack mechanical ventilation Meta-analysis morbidity and mortality Mortality overlapping presenting qualitative analysis ranged reduce reducing required risk robust Safe screened selected Seven severity of COVID-19 systematic review systematic reviews therapy Trial Vitamin D supplementation were assessed [DOI] 10.1093/qjmed/hcac040 PMC 바로가기
SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identificationArticle Published on 2022-10-252022-11-16 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Accuracy Analysis approach association Blood build complex component COVID-19 severity dataset eQTL etiology explain expression Gene Expression Genetic Genome-wide association study identify IMPROVE loci low expression modeling moderate proportion provided Quantitative regulated severity Simulation study Statistical power traits transcriptome-wide transcriptomic data with COVID-19 [DOI] 10.1038/s41467-022-34016-y PMC 바로가기
Severity predictors of COVID-19 in SARS-CoV-2 variant, delta and omicron period; single center studyArticle Published on 2022-10-252022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis analyzed Appropriate BMI body mass index cause caused changes in Characteristics city Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 severity cut-off value Dyspnea groups Hospitalization laboratory data LDH management moderate Moderate COVID-19 multiple logistic regression Omicron variant outcome Patient predictor progression renal dysfunction SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe COVID-19 Sex significant difference significantly single center smoking sore throat specificity Symptoms the disease time Treatment treatment regimens two group university vaccination variant Yokohama [DOI] 10.1371/journal.pone.0273134 PMC 바로가기
Severity of Illness Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern in Children: A Single-Center Retrospective Cohort StudyArticle Published on 2022-10-252022-11-16 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI age Alpha analyses children clinical Community concern coronavirus 2 COVID-19 COVID-19 infection COVID-19 severity diagnosed with COVID-19 FIVE Frequency Gamma Hospitalization ICU admission illness Illumina immunization incidence increasing age marker medical condition Medical conditions outcome outcomes performed pharmacologic treatment prevented recent Regression model respiratory Respiratory Support retrospective cohort study SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 variant scale Sequencing severe COVID-19 severe disease severity single-center the WHO VoC VOCs were infected with COVID-19 [DOI] 10.1093/jpids/piac068 PMC 바로가기
Potential Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2Article Published on 2022-10-162022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Anti-inflammatory antioxidant antiviral drug applied caused clinical trial Combination contagious coronavirus COVID-19 COVID-19 disease COVID-19 severity disease Diseases drug effective Efficacy experiment Immunity immunomodulatory effects Infection melatonin mutations omicron Omicron variant (B.529) Other outbreak Outbreaks over oxidative oxidative stress Potential Prevent reduce reducing safety profile SARS-CoV-2 severe symptom severity shown significant effect the disease therapeutic Therapeutic approach therapeutic approach. therapeutic drug therapy treat Treatment unique Vaccine variant [DOI] 10.3390/molecules27206934 PMC 바로가기