Kappa-RBD produced by glycoengineered Pichia pastoris elicited high neutralizing antibody titers against pseudoviruses of SARS-CoV-2 variantsglycoengineered Pichia pasteris에 의해 생산된 Kappa-RBD는 SARS-CoV-2 변이체의 슈도바이러스에 대한 높은 중화 항체 역가를 유발했습니다.Article Published on 2022-04-012022-09-11 Journal: Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alum aluminum aluminum hydroxide Antibody titers antigen-specific antibody B.1.617.1 BALB/c mice Beta candidate vaccine coronavirus COVID-19 vaccine CpG domain elicited expression hydroxide India induce Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Omicron variant Omicron variants Pichia pastoris platform produced pseudoviruses pseudoviruses of SARS-CoV-2 RBD Receptor-binding domain Receptor-binding domain (RBD) respiratory SARS-CoV-2 SARS-CoV-2 kappa severe acute respiratory syndrome Coronavirus the epidemic Vaccine variant VoC was used wild-type yeast [DOI] 10.1016/j.virol.2022.03.001 PMC 바로가기 [Article Type] Article
The Slowing Rate of CpG Depletion in SARS-CoV-2 Genomes Is Consistent with Adaptations to the Human HostSARS-CoV-2 게놈에서 CpG 고갈의 둔화 속도는 인간 숙주에 대한 적응과 일치합니다Discoveries Published on 2022-03-032022-09-10 Journal: Molecular Biology and Evolution [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptation alpha- analyzed Antiviral antiviral protein Beta coding regions codon positions Coronavirus-2 CpG CpG depletion Depletion dinucleotide driven by equilibrium Evidence Evolution full-length SARS-CoV-2 genome Genome genomes help highest highlight Host Human human host immune immune responses Infection innate immune responses Loss majority motif motifs occur pandemic Rate reduced representing respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes selection pressure sequence sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Temporal temporal variation TLR7 variants of concern Variation variations virus Virus evolution virus genome virus genomes virus replication ZAP ZAP-binding motif Zinc [DOI] 10.1093/molbev/msac029 PMC 바로가기 [Article Type] Discoveries
The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAPSARS-COV-2 게놈에서 CPG의 낮은 풍부는 진화론 적으로 ZAP의 서명이 아닙니다.Article Published on 2022-02-142022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] acting Analysis Antiviral antiviral protein binding Computational biology and bioinformatics coronavirus CpG Degradation dinucleotides enzyme Evidence genetics Host Hypothesis performed Protein Region restrict viral replication RNA SARS-CoV-2 SARS-CoV-2 genome sequence shown the SARS-CoV-2 genome These data Viral viral replication Viral RNA ZAP Zinc zinc finger antiviral protein [DOI] 10.1038/s41598-022-06046-5 PMC 바로가기 [Article Type] Article
Efficacy of the adjuvanted subunit protein COVID-19 vaccine, SCB-2019: a phase 2 and 3 multicentre, double-blind, randomised, placebo-controlled trial보조제 서브유닛 단백질 COVID-19 백신, SCB-2019의 효능: 2상 및 3상 다기관, 이중 맹검, 무작위 배정, 위약 대조 시험Clinical Trial Published on 2022-01-292022-09-11 Journal: Lancet (London, England) [Category] 변종, 임상, [키워드] 1:1 95% CI alum assigned baseline Belgium biopharmaceutical Brazil caused chloride circulating Clover Coalition country COVID 19 COVID-19 COVID-19 case COVID-19 vaccine CpG Cutoff dose doses double-blind effective vaccine Effective vaccines Efficacy efficacy analysis elicited Endpoint enrolled EudraCT exclusion FIVE follow-up period groups Health health condition injection injection site pain intramuscular dose Local median Mild-to-moderate moderate-to-severe COVID-19 MOST multicentre notable Older pandemic participant per-protocol per-protocol population Phase 2 Placebo placebo recipients placebo-controlled trial predominant primary endpoints Protein provide randomisation randomised Randomly receive Registered RT-PCR Safe SAR-CoV-2 SARS CoV SARS-CoV-2 SCB-2019 second dose seronegative participant Seropositivity severe COVID-19 severity Sodium chloride South Africa subset subunit systemic adverse event systemic adverse events Vaccine vaccine efficacy vaccinee vaccinees variant virus virus variants viruses was done [DOI] 10.1016/S0140-6736(22)00055-1 PMC 바로가기 [Article Type] Clinical Trial
Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 VaccinationImmunology Published on 2022-01-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation adaptive adenoviral vector vaccine adenovirus vector vaccine age antibody Antibody titer association AZD1222 B cell CD14 CD27 CD3 CD56 CD86 Cell ChAdOx1 nCoV-19 collected connection correlated CpG Critical cytokine production double-negative B cell enrolled Ex vivo expression first vaccination FIVE flow cytometry granzyme B IFN-γ IGD imiquimod Immune cell immune response Immunity immunosenescence information Innate innate immune innate immune activation innate immune response Innate immunity LPS marker memory B cell monocyte naïve naïve B cell natural killer neutralization Neutralizing antibodies neutralizing antibody NK cell Older pattern recognition receptor Production response responses Result SARS-CoV-2 vaccines SARS-CoV2 serum significantly higher stimulated subject sVNT TLR TLR agonist TLR stimulation TLR9 Toll-like receptor vaccination vaccinee Virus neutralization were measured [DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology
The substitution spectra of coronavirus genomes코로나 바이러스 게놈의 치환 스펙트럼Problem Solving Protocol Published on 2022-01-132022-09-10 Journal: Briefings in Bioinformatics [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect animal coronavirus Animal coronaviruses Apolipoprotein B avoidance can not catalytic change Complete coronavirus coronavirus genome CpG decrease determined by dinucleotide effort eliminated Evidence evidence of expected Factors Frequency Host hosts Increases information International intrinsic Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus mRNA Mutation nucleotide pandemic positive-sense proportion proportions Protein reduction Replication respiratory respiratory syndrome coronavirus RNA viruses SARS-CoV-2 SARS-CoV-2 pandemic selective sequence severe acute respiratory syndrome Coronavirus Spread Substitution substitutions transitions transversions triggered Viral viral genomes [DOI] 10.1093/bib/bbab382 PMC 바로가기 [Article Type] Problem Solving Protocol
Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates비인간 영장류에서 COVID-19에 대한 재조합 식물 유래 바이러스 유사 입자 백신 후보의 비보조제 및 애주번트 제형이 제공하는 안전성, 면역원성 및 보호Article Published on 2022-01-052022-09-12 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), MERS, SARS, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome adjuvant adjuvants administration animal Antiviral AS03 BALF booster Bronchoalveolar lavage fluid CD4 T cells Cell-mediated immune responses chemotactic factor clinical trials coronavirus coronavirus disease COVID-19 CoVLP CoVLP vaccine CpG CpG1018 demonstrated dose effective vaccine Efficacy Evidence expression humoral IL-4 Immune cell immunization immunized Infection Influenza Intramuscular injection intranasal Lower lung nasal swab Non-humane primates ocular pandemic pathologic plaque-forming unit priming Proinflammatory cytokine Protein vaccines provided reduced responses rhesus macaque Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2-infected cell selected significantly single dose stimulated System vaccine candidate Vaccine development vaccine-associated enhanced disease viral replication virus-like particle vaccine virus-like particles VLP [DOI] 10.1038/s41423-021-00809-2 PMC 바로가기 [Article Type] Article
Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infectionCOVID-19 감염에 대한 바이러스 유사 입자 백신의 개발 및 전임상 평가Article Published on 2022-01-012022-09-12 Journal: Allergy [Category] SARS, 진단, [키워드] AFM alum anti-N IgG anti-RBD anti-S breadth cellular characterized COVID-19 COVID-19 infection CpG CpG ODN Adjuvant demonstrated development elicited expressing HEK293 cell HEK293 cells humoral immune response Humoral immunity identity immune immunized immunoblotting immunogenic Live virus Lung pathology multifunctional prevented PROTECT Protein protein antigen pulse purified reduced SARS-CoV-2 SARS-CoV-2 antigen SEM structural protein T-cell responses TEM transiently transfected triggered vaccination Vaccine virus load Virus-like particle virus-like particle vaccine VLP VLPs [DOI] 10.1111/all.15091 PMC 바로가기 [Article Type] Article
Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expressionSARS-CoV-2 감염과 관련된 분자 과정의 위험 중심적 차이: DNA 메틸화 및 유전자 발현의 결과Research Published on 2021-12-112022-09-11 Journal: Epigenetics & Chromatin [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Air pollutants airway epithelia Analysis ARRB2 association Asthma autosomal Bronchoalveolar lavage CA5B candidate gene changes in chronic conditions chronic obstructive COMT conducted COPD coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 susceptibility CpG data set Diagnosis diesel exhaust DNA methylation downloaded epithelia exaggerated immune response exhibited explain Exploratory analysis exposure to Factor female Gene Expression gene expression patterns Genes GEO GPX1 Health highlight HS6ST2 immune genes imperative implicated inactivation increased risk individual Infection infections investigated involved loci lung magnitude male molecular molecular association molecular associations molecular basis molecular pattern molecular patterns mRNA expression nasal Nicotine nicotine dependence nitrogen nitrogen dioxide NLRP2 outcomes portal PRIM2 profile Repository respiratory Respiratory conditions Respiratory disease respiratory tissue Result risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Sex Sex difference Smokers smoking suggested supplementary material susceptibility TATDN1 the disease TLE1 understanding Variation while Whole blood X-linked X-linked gene [DOI] 10.1186/s13072-021-00428-1 PMC 바로가기 [Article Type] Research
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2Research Article Published on 2021-12-082022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory syndrome Adding adjuvant aluminum hydroxide amplify Antigen binding clearance component coronavirus CpG description effective Efficacy elicit ENhance Humoral immunity humoral responses immunization immunogen increases in lymph nodes mice molecular Neutralizing antibody titer neutralizing response notable Particle peptide RBD Receptor binding domain response rhesus macaques Saponin SARS-CoV-2 SARS-CoV-2 variants subunit vaccines vaccination Vaccine vaccine immunogenicity [DOI] 10.1126/sciadv.abj6538 PMC 바로가기 [Article Type] Research Article