N-Glycosylation of the SARS-CoV-2 Receptor Binding Domain Is Important for Functional Expression in PlantsPlant Science Published on 2021-06-152022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] ACE2 Amino acid antibody benthamiana binding cellular receptor characterized complex convalescent sera COVID-19 CR3022 enzyme expressed glycoprotein glycosylated glycosylation growth factor had no Host monoclonal antibodies monomer N-glycan N-glycosylation Nicotiana benthamiana plant posttranslational modification Protein protein expression RBD Receptor binding domain Recombinant protein recombinant proteins SARS-CoV-2 secreted site-directed mutagenesis Spike protein the SARS-CoV-2 variant Variation Viral antigen virus while [DOI] 10.3389/fpls.2021.689104 PMC 바로가기 [Article Type] Plant Science
Nano-layered surface plasmon resonance-based highly sensitive biosensor for virus detection: A theoretical approach to detect SARS-CoV-2Regular Articles Published on 2021-06-142022-10-28 Journal: AIP Advances [Category] COVID-19, [키워드] Accuracy antibody approach coronavirus disease COVID-19 CR3022 detect Health Interaction measure Medicine outbreak pandemic patients respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 variants sensitivity Spread structures treat Vaccine virus virus detection [DOI] 10.1063/5.0046574 PMC 바로가기 [Article Type] Regular Articles
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants최근 SARS-CoV-2 변이체에서 항원 드리프트의 구조적 및 기능적 파급효과Report Published on 2021-05-202022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 binding analyzed antibody antigenic B.1.351 binding modes Brazil conserved COVID-19 patients CR3022 cross-neutralizing described E484K E484K mutation E484K mutations Effect effective elicited explained functional IGHV1-2 implication Interaction K417 K417N less mutated NAb NAbs neutralization Neutralizing antibodies P.1 RBS residue S309 SARS-CoV-2 variant South Africa Spike protein the spike protein Therapies Vaccine variant variants variants of concern wild-type SARS-CoV-2 [DOI] 10.1126/science.abh1139 PMC 바로가기 [Article Type] Report
Integrated Biophysical Modeling of the SARS-CoV-2 Spike Protein Binding and Allosteric Interactions with AntibodiesSARS-CoV-2 스파이크 단백질 결합 및 항체와의 알로스테릭 상호작용의 통합 생물물리학적 모델링Article Published on 2021-05-132022-09-11 Journal: The journal of physical chemistry. B [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Analysis antibodies antibody approach binding biochemical change Cluster complexes Complexes conformational CR3022 cross-talk deep mutagenesis demonstrated domain epitope Epitopes functional Hierarchical highlighting hotspot in silico mechanism modeling modulating modulation molecular dynamics Molecular dynamics simulation molecular mechanism molecular mechanisms molecular simulations Mutation network analysis neutralization panel of antibody Perturbation plasticity Quantitative RBD Region Regulatory responses S proteins S309 SARS-CoV-2 S protein SARS-CoV-2 spike proteins sensitivity Severe acute respiratory syndrome Signaling spike spike glycoprotein Spike protein Spike proteins spike trimer the SARS-CoV-2 [DOI] 10.1021/acs.jpcb.1c00395 PMC 바로가기 [Article Type] Article
A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection교차 중화 항체의 조합은 SARS-CoV-2 및 SARS-CoV 슈도바이러스 감염을 예방하기 위해 상승합니다.Article Published on 2021-05-122022-09-10 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] 3D structure Abstract antibodies antibody antibody cocktail antibody-antigen interaction antigenic antigenic drift antigenic variation B.1.1.7 B.1.351 bind bound waters caused circulating variant circulating variants Combination complex conserved coronavirus coronavirus disease Coronavirus disease 2019 COVA1-16 COVID-19 COVID-19 patient CR3022 cross-neutralizing cross-neutralizing antibodies cross-neutralizing antibody cross-react cross-reactivity crystal structure crystal structures Crystallography Effectiveness ENhance Epidemics facilitate glycan glycosylation site Infection information interact Interaction neutralization neutralize Neutralizing antibodies Pandemics Prevent PROTECT provide receptor-binding domains Recognition related viruses S309 Sarbecoviruses SARS-CoV SARS-CoV pseudovirus SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related coronaviruses SARS-related virus SARS-related viruses shown spike spikes Structure synergy the receptor-binding domain therapeutic therapeutic antibodies these viruses threat Threats Vaccine viruses X-ray zoonotic [DOI] 10.1016/j.chom.2021.04.005 PMC 바로가기 [Article Type] Article
Nicotinic cholinergic system and COVID-19: In silico identification of interactions between α7 nicotinic acetylcholine receptor and the cryptic epitopes of SARS-Co-V and SARS-CoV-2 Spike glycoproteins니코틴성 콜린성 시스템과 코로나19: α7 니코틴성 아세틸콜린 수용체와 SARS-Co-V 및 SARS-CoV-2 스파이크 당단백질의 비밀 에피토프 간의 상호작용에 대한 실리코(in silico) 식별Article Published on 2021-03-012022-09-12 Journal: Food and chemical toxicology : an international jo [Category] SARS, 유전자 메커니즘, 진단, [키워드] adverse outcome agonists anti-SARS-CoV antibody binding site Clinical effect conformations coronavirus COVID-19 CR3022 Cryptic epitope diagnosed dysregulated epitope glycoprotein higher odd homology Hospitalized Hypothesis Interaction less molecular complex Molecular modeling monoclonal antibody nAChRs. pathway protective role protein complex receptor SARS-Co-V SARS-CoV SARS-CoV-2 sequence shown smoker spike spike glycoprotein Spread Support the Spike therapeutic Wuhan [DOI] 10.1016/j.fct.2021.112009 PMC 바로가기 [Article Type] Article
Dissecting strategies to tune the therapeutic potential of SARS-CoV-2–specific monoclonal antibody CR3022SARS-CoV-2-특이적 단일클론항체 CR3022의 치료 가능성을 조정하기 위한 해부 전략Research Article Published on 2021-01-112022-09-10 Journal: JCI Insight [Category] 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antibody Antigen coronavirus COVID-19 CR3022 Critical effort Epidemiology function functional functions globe hamsters highlighting IgG1 immune clearance immunology infected cell infected cells Infection Interaction lack mice monoclonal antibody mutations pathology respiratory SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spread susceptible therapeutic potential Therapeutics Treatment variant variants Viral viral replication virus weight loss [DOI] 10.1172/jci.insight.143129 PMC 바로가기 [Article Type] Research Article
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies상징적인 SARS-CoV-1 항체의 성숙을 통한 강력한 SARS-CoV-2 결합 및 중화Article Published on 2021-01-012022-09-11 Journal: mAbs [Category] 변종, 진단, [키워드] 2003 SARS 80R antibody antibody engineering antibody maturation binding clone coronavirus coronavirus coronavirus spike protein CR3014 CR3022 Cryo-electron microscopy Crystallography disease domain effort emerging viruses Epitopes Infection m396 mAb mAbs maturation monoclonal antibodies monoclonal antibody neutralization neutralize open outbreak parental phage display potent PROTECT SARS-CoV-1 SARS-CoV-2 specificity Spike protein structural studies. the SARS-CoV-2 variant variants viruses X-ray crystallography [DOI] 10.1080/19420862.2021.1922134 PMC 바로가기 [Article Type] Article
A New Crystal Form of the SARS-CoV-2 Receptor Binding Domain: CR3022 Complex—An Ideal Target for In-Crystal Fragment Screening of the ACE2 Binding Site SurfacePharmacology Published on 2020-12-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 ACE2 binding site antibody antiviral molecule cells complex CR3022 crystal develop Drug discovery form fragment ideal identify in-crystal fragment screening inhibitors New powerful tool PPI inhibitors probe Protein SARC-CoV-2-RBD Screening Site surface target the SARS-CoV-2 virus entry [DOI] 10.3389/fphar.2020.615211 PMC 바로가기 [Article Type] Pharmacology
A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibodySARS-CoV-2와 SARS-CoV 사이의 자연 돌연변이는 교차 반응성 항체에 의한 중화를 결정합니다Research Article Published on 2020-12-042022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 변종, 진단, [키워드] Amino acid antibody antibody cross-reactivity antigenic variation Author binding binding affinity caused conformations conserved convalescent SARS patient CoV antibodies COVID-19 pandemic CoVs CR3022 CR3022 epitope cross-neutralizing epitope cross-react cross-reactive antibody cross-reactive vaccine cross-reactive vaccines cryo-EM determine Epidemic epitope Epitopes experiments Fab Genetic implication Interaction investigated Mutagenesis mutant N-terminal domain natural mutation neutralization neutralizing antibody not neutralize NTD P384A provide RBD Receptor binding domain SARS-CoV SARS-CoV antibodies SARS-CoV antibody SARS-CoV spike protein SARS-CoV-2 SARS-like coronavirus SARS-like coronaviruses SARS-like CoV SARS-like CoVs SARS-like viruses similarity single mutation Spike protein subunit target the RBD the spike protein therapeutic Therapeutics trimer Vaccine X-ray crystallography [DOI] 10.1371/journal.ppat.1009089 PMC 바로가기 [Article Type] Research Article