CRISPR-Cas9 – Page 3 – Communicable Diseases Research

Organoid based personalized medicine: from bench to bedside

Review

Published on 2020-11-022022-10-31
Journal: Cell Regeneration
[Category] COVID-19,

Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

Research Article

Published on 2020-10-262022-10-31
Journal: eLife
[Category] COVID-19, SARS,

[키워드] ACE-2 ACE2 ACE2 receptor applied approach binding blocked blocking both virus Brain carbohydrate caused Cell cells changes complex COVID-19 CRISPR-Cas9 Critical disrupt domain evaluated examined experiment expressed expressing furin Genetic glycan glycans glycoprotein glycoscience glycosylated glycosylation HEK293T cells helping highlight Host host cells Human human kidney human protein illnesses infect Infectious disease inhibition inhibitor interfere kidney kifunensine Laboratory less Lungs modify post-translational modification Protein RBD receptor ACE2 reduce reduced Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 viral spike spike-ACE2 stick Structure sugar sugar molecule the Spike treat Treatment Vaccines viral entry virus virus
[DOI] 10.7554/eLife.61552 PMC 바로가기 [Article Type] Research Article

Synaptogyrin-2 influences replication of Porcine circovirus 2

Synaptogyrin-2는 돼지 써코바이러스 2의 복제에 영향을 미칩니다

Research Article

Published on 2018-10-312022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Affect Amino acid Antigen association Author Cas9 Cell chromosome chromosome 7 clone complex conducted conserved CRISPR CRISPR-Cas9 disease disease susceptibility Diseases Dissection DNA virus domain Evidence evidence of ExoN explained expression General health Genetic genetic component genetic test genetic tests genetics Genome-wide association study genomic Genotype group of disease group of diseases growth Health Host host genetics hpi identification illnesses immune response immune system in viral incidence Infection influence involved leukocyte locus mammals Missense mutation Mutation Pathogenesis phenotypic phenotypic variance phenotypic variation PIGS polymorphism Population predict Protein provided proximal end QTL replicate Replication Research responsible RNA-sequencing severity sick single-stranded DNA SNP suggested supernatant susceptibility susceptible SYNGR2 the strongest underlie variant Variation Viral Viral load viral replication viral titer Viremia virus Welfare wildtype
[DOI] 10.1371/journal.pgen.1007750 PMC 바로가기 [Article Type] Research Article

Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia

GLS2의 인간 유전적 변이는 복잡한 황색 포도구균 균혈증의 발병과 관련이 있습니다

Research Article

Published on 2018-10-052022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activate age allele Analysis association Bacteremia Bacteria Bacterial Blood cells bloodstream Bonferroni correction candidate gene capture cause causes Cell coding variant complex Complication Control correlated CRISPR CRISPR-Cas9 cumulative cumulative effect death eight ENCODE evaluated examined exhibited Exome expression expression level Factor Frequency gene-based analysis gene-expression Genetic genetic factors genetic risk factor Genetic variant genetic variants Genetic variation Genome GLS2 Glutamine growth healthy controls Hospitalization Host Human Human genome immune response individual Infection infections Interaction key factor leukocyte leukocyte activation Logistic regression analysis Macrophage macrophage cells metabolism Microarray missense variant nitric oxide plasma concentration Protein regulate Regulatory Replication risk S . aureus sequence Sequencing Sex significantly significantly lower Staphylococcus aureus susceptible the strongest These cells Transcription variant variants Variation variations WES White blood cell White blood cells wild-type cells
[DOI] 10.1371/journal.pgen.1007667 PMC 바로가기 [Article Type] Research Article

Removal of Integrated Hepatitis B Virus DNA Using CRISPR-Cas9

Original Research

Published on 2017-03-222023-06-03
Journal: Frontiers in Cellular and Infection Microbiology
[Category] B형 간염,

[키워드] CRISPR-Cas9 HBV cccDNA Hepatitis B virus integrated HBV DNA Whole genome sequencing
[DOI] 10.3389/fcimb.2017.00091 PMC 바로가기 [Article Type] Original Research