Effect of interleukin-6 receptor antagonists in critically ill adult patients with COVID-19 pneumonia: two randomised controlled trials of the CORIMUNO-19 Collaborative GroupCOVID-19 폐렴이 있는 위독한 성인 환자에서 인터루킨-6 수용체 길항제의 효과: CORIMUNO-19 공동 그룹의 2건의 무작위 대조 시험Article Published on 2022-08-102022-09-11 Journal: The European Respiratory Journal [Category] Fulltext, SARS, 임상, [키워드] 95% CI antagonist anti-IL-6 receptor assigned Bayesian clinical trials clinically controlled clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 credible interval CrI Critically ill Critically ill patient critically ill patients determine Effect events group hazard ratio IMPROVE indicated interleukin-6 receptor intravenously investigator-initiated mechanical ventilation median multicentre NIV Noninvasive ventilation not need numbers of patient Open-label outcome Patient patients with COVID-19 Pneumonia posterior probability randomised randomised controlled randomised controlled trial Randomly receive receptor risk of death SARI sarilumab significantly TCZ TOCI Tocilizumab Trial usual care with COVID-19 [DOI] 10.1183/13993003.02523-2021 PMC 바로가기 [Article Type] Article
Role of therapeutic plasma exchange in the management of COVID-19-induced cytokine storm syndromeReview article Published on 2022-08-012022-10-05 Journal: Transfusion and apheresis science : official journ [Category] SARS, 바이오마커, 임상, 치료제, [키워드] member 13 a disintegrin and metalloproteinase with a thrombospondin type 1 motif acute respiratory syndrome ADAMTS-13a disintegrin and metalloproteinase with a thrombospondin type 1 motif American Society for Apheresis approach ARDSacute respiratory syndrome article ASFAAmerican Society for Apheresis available data benefit C-reactive protein Case series Case-control CCPCOVID-19 convalescent plasma Clinical outcome Coagulopathy conducted Controlled clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent plasma COVID-19coronavirus disease 2019 criteria Critically ill patient CRPC-reactive protein CSS CSScytokine storm syndrome Cytokine storm syndrome Cytokines D-dimer Effects Evidence excessive immune response feasibility ferritin FFPfresh frozen plasma fibrinogen level fresh frozen plasma hypercoagulable Hyperinflammatory ICUIntensive Care Unit identify IFNinterferon ILInterleukin immunomodulatory effect improvement Inflammatory factor intensive care unit interferon interleukin interleukin-6 Intervention Length of stay LOSlength of stay Lymphocyte count macrophage activation syndrome management MASmacrophage activation syndrome MODSmultiple organ dysfunction syndrome Mortality multiple organ dysfunction syndrome offer offset PaO2:FiO2pressure of arterial oxygen to fractional inspired oxygen concentration pathologic Patient patients patients with COVID-19 peer-reviewed potential clinical benefits pressure of arterial oxygen to fractional inspired oxygen concentration prevent disease progression Randomized Randomized controlled trial RCTrandomized controlled trial reduce reduce mortality resulting risk role Safe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 secondary hemophagocytic lymphohistiocytosis selected Sequential Organ Failure Assessment severe acute respiratory syndrome coronavirus 2 sHLHsecondary hemophagocytic lymphohistiocytosis SOFASequential Organ Failure Assessment TAMOFthrombocytopenia-associated multiple organ failure Therapeutic plasma exchange thrombocytopenia-associated multiple organ failure TNFTumor Necrosis Factor TPE TPEtherapeutic plasma exchange treat Treatment tumor necrosis factor while with COVID-19 [DOI] 10.1016/j.transci.2022.103433 [Article Type] Review article
Treatment strategies of COVID-19: A rheumatology perspectiveCOVID-19의 치료 전략: 류마티스학적 관점Review Published on 2022-08-012022-09-12 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 진단, 치료법, 치료제, [키워드] absence acute respiratory syndrome adaptive approved authority Colchicine Coronavirus-2 Corticosteroid COVID-19 Critical Critically ill patient Dexamethasone DMARDs effective host cell Immunity Inflammatory response inhibitors interleukin-6 janus Kinase inhibitor mAbs monoclonal antibody off-label Perspective plethora progression Proinflammatory cytokine Remdesivir Replication rheumatologist rheumatology SARS-CoV-2 SARS-CoV-2 mAbs. SARS-CoV-2 pneumonia therapeutic strategy Treatment viral entry [DOI] 10.1016/j.ejim.2022.05.014 PMC 바로가기 [Article Type] Review
Diagnostic value of serum KL-6 and IL-6 levels in critically ill patients with COVID-19-associated pneumoniaCorrespondence Published on 2022-08-012022-10-05 Journal: The Journal of Infection [Category] 바이오마커, 진단, [키워드] COVID-19 Critically ill patient IL-6 level interleukin-6 Krebs von den Lungen-6 Mortality Pneumonia SARS-CoV-2 serum [DOI] 10.1016/j.jinf.2022.08.016 [Article Type] Correspondence
In situ simulation training for a better interprofessional team performance in transferring critically ill patients with COVID-19: a prospective randomised control trialRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: Postgraduate medical journal [Category] 임상, [키워드] adult intensive & analysed assigned Care Critical Critical care Critically ill patient demonstrated determine group groups Health IMPROVE Intensive Mann-Whitney test MEDICAL EDUCATION & pandemic participant patients with COVID-19 protocols randomised significantly subject training. transfer transferring Trial unpaired t test with COVID-19 [DOI] 10.1136/postgradmedj-2021-141426 PMC 바로가기 [Article Type] Randomized Controlled Trial
Anticoagulation Strategies in Critically Ill Patients With SARS-CoV-2 Infection: The Role of Direct Thrombin InhibitorsObservational Study Published on 2022-08-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] SARS, 임상, [키워드] acute respiratory syndrome addition Anticoagulant anticoagulation bivalirudin bleeding bleeding event Cohort comparable coronavirus Critical Critical care Critically ill patient Direct effective extracorporeal membrane oxygenation extracorporeal membrane oxygenation. hospital Ill Infection intensive care intravenous measurement Mortality mortality risk no difference Occurrence participant Patient patients treated receiving role Safe SARS-CoV-2 SARS-COV-2 infection Strategy subgroup analysis Support thromboembolic complication thrombotic complication university hospital [DOI] 10.1053/j.jvca.2022.03.004 PMC 바로가기 [Article Type] Observational Study
COVID-19-associated pulmonary aspergillosis is associated with increased in-hospital mortality and prolonged SARS-CoV-2 viral sheddingResearch article Published on 2022-08-012022-10-05 Journal: Journal of the Formosan Medical Association = Taiw [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome adjusted odds ratio Analysis analyzed Asian Aspergillus CAPA clinical factor coronavirus Coronavirus disease 2019 Corticosteroid COVID-19 Critically ill patient Diagnosis enrolled fibrinogen fibrinogen level ICU admission ICUs in-hospital mortality in-hospital mortality rate incidence rate intensive care unit investigated Lower mechanically ventilated patients median time outcomes Patient patients with COVID-19 polymerase chain Population Result reverse transcription SARS-CoV-2 SARS-CoV-2 viral shedding serum Treatment outcome Virus shedding with COVID-19 [DOI] 10.1016/j.jfma.2022.07.006 [Article Type] Research article
Soluble CD137 as a potential biomarker for severe COVID-19Article Published on 2022-08-012022-10-05 Journal: Immunology letters [Category] 바이오마커, [키워드] 24 hour acute respiratory syndrome Analysis Biomarker Blood Brazil Care caused CD137 characterized Clinical outcome contagious Control coronavirus Coronavirus disease 2019 correlation COVID-19 critical COVID-19 patient Critically ill patient cytokine Cytokines demonstrated disease disease severity evaluate evaluated growth factor Growth factors Health healthy blood donors high risk highly pathogenic hospital ICU ICU admission identify immune increase in increased risk Infection intensive care isoform mechanical ventilation membrane-bound mortality rate Necrosis outcomes pandemic Potential biomarker potential therapy primary endpoint Prospective Study receptor recruitment regulate responsible SARS-CoV-2 severe COVID-19 severe SARS-CoV-2 severity Soluble CD137 Soluble immune checkpoints T-cell activation therapeutic targets TNF was related was used WHO with COVID-19 World Health Organization [DOI] 10.1016/j.imlet.2022.07.003 [Article Type] Article
Mortality of Mechanically Ventilated COVID-19 Patients in Traditional versus Expanded Intensive Care Units in New YorkMulticenter Study Published on 2022-08-012022-10-06 Journal: Annals of the American Thoracic Society [Category] 진단, [키워드] 95% CI 95% confidence interval cohort study coronavirus disease COVID COVID pandemic COVID-19 COVID-19 patient COVID-19 patients Critical care Critically ill Critically ill patient died discharged evaluate expanded ICU First wave greater hazard ratio health system hospital hospital occupancy for critically ill patients ICU ICUs in-hospital mortality increased mortality increased risk intensive care unit intubation mechanically ventilated mechanically ventilated COVID-19 patients mechanically ventilated patient Mortality New York New York City not different outcome pandemic Patient resulting retrospective risk surpassed survived Traditional traditional ICU. transferred with COVID-19 [DOI] 10.1513/AnnalsATS.202106-705OC PMC 바로가기 [Article Type] Multicenter Study
The utility of CRP with the use of dexamethasone and Tocilizumab in critically ill patients with COVID-19COVID-19가 있는 중환자에서 덱사메타손과 토실리주맙을 사용하는 CRP의 유용성Article Published on 2022-08-012022-09-12 Journal: Journal of critical care [Category] 바이오마커, 진단, [키워드] Critically ill patient CRP Dexamethasone utility with COVID-19 [DOI] 10.1016/j.jcrc.2022.154053 PMC 바로가기 [Article Type] Article