Effect of Chloroquine and Hydroxychloroquine on Cytokine Release Syndrome in Patients with COVID-19COVID-19 환자의 사이토카인 방출 증후군에 대한 클로로퀸 및 하이드록시클로로퀸의 효과Randomized Controlled Trial Published on 2021-12-012022-09-11 Journal: Clinical medicine & research [Category] SARS, 임상, 치료기술, 치료제, [키워드] Adult patients age blinded Care Chain Reaction Chloroquine conducted coronavirus disease Coronavirus disease 2019 COVID-19 CRS Cytokine release syndrome Department diagnose diagnoses Effect electrochemiluminescence immunoassay Emirate enrolled hospitalized patient Hydroxychloroquine IL-6 interleukin interleukin 6 Medicine Mild mild to moderate mild to moderate symptoms moderate no effect no significant difference onset of symptom Patient patients patients with COVID-19 placebo-controlled polymerase chain polymerase chain reaction randomization randomized study reducing Release Result reverse transcription reverse transcription polymerase chain reaction Roche RT-PCR screened serum sample serum samples significant difference study groups Symptoms the mean the patient three groups Treatment with COVID-19 [DOI] 10.3121/cmr.2021.1659 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clonal Hematopoiesis of Indeterminate Potential Is Associated with Increased Age-Independent Morbidity and Mortality in Patients with COVID-19- the Beyond DNA COVID-19 ProjectConference abstract Published on 2021-11-242022-10-05 Journal: Blood [Category] 변종, [키워드] accounted affected age age and sex allele approved assays association ASXL1 ATAC-seq baseline Blood blueprint carried ChIP clinically collected common Comorbidities comparable Coverage COVID-19 COVID-19 diagnosis COVID-19 disease severity COVID-19 patient CRP CRS cytokine cytokine levels Cytokine release syndrome Cytokines database death defined described Detection limit DNA download elevated ELISA assay entire cohort figure Fisher Follow-up funding Genes grade 3 group had more hazard healthy individual Hematopoiesis Hospitalization hypoxemic hypoxic respiratory failure identify IL6 Increased increased mortality indeterminate indicated individuals Infection Inflammation Inflammatory inflammatory cascade Inflammatory marker IRB male Mayo Clinic MCP-1 median median age mononuclear cell morbidity Mortality MPL Mutation mutations neutropenia no difference observé Older pathophysiology Patient patients patients with COVID-19 PBMC Peripheral blood Potential proteomic study reached regression models remained Research resolved Respiratory failure RNA scale Sequencing severe disease severity Sex SF3B1 Single Cell ssDNA subsequent survival survival analysis TET2 the Kaplan-Meier method the WHO TNF-a TP53 two groups variables variant was performed WHO Wilcoxon rank sum with COVID-19 [DOI] 10.1182/blood-2021-151548 [Article Type] Conference abstract
Dehydrozingerone ameliorates Lipopolysaccharide induced acute respiratory distress syndrome by inhibiting cytokine storm, oxidative stress via modulating the MAPK/NF-κB pathwayDehydrozingerone은 MAPK/NF-κB 경로를 조절하여 사이토카인 폭풍, 산화 스트레스를 억제함으로써 지질다당류 유도 급성 호흡 곤란 증후군을 개선합니다Article Published on 2021-11-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome alveolar alveolar inflammation analysed Analysis Apoptosis ARDS Bacterial BALF Cell cell damage cell injury cell lines chemokine chemokines country COVID-19 pandemic CRS cytokine Cytokine release syndrome Cytokine storm Cytokines Dehydrozingerone develop distress dose-dependent manner Elastase ELISA Endothelial cell endothelial cells evaluated event events Gene Expression Health Hyperactivation immune cells In-vitro increase in Infection Inflammation Inflammatory inflammatory cascade inflammatory cell inflammatory cells Inflammatory cytokine Inflammatory cytokines inhibiting Injury intensive care units lipopolysaccharide LPS lung cell lung epithelial Lung injury lung tissues macrophages majority MAPK MAPKinase marker modulating modulation molecular mechanism molecular mechanisms morbidity neutrophil NF-κB NF-κB pathways oxidative oxidative stress pathogen pathogen-mediated pathophysiology pathway performed Pneumonia problem Prophylactic protective effect Protective effects Protein provide RATs reduced respiratory distress resulting ROS significantly Standard therapy stimulate stimulated Support syndrome the patient therapeutic therapeutic activity therapeutic agent therapeutic effect therapeutic effects Treatment turn was determined western blot Western blot analysis [DOI] 10.1016/j.phymed.2021.153729 PMC 바로가기 [Article Type] Article
Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational studyObservational Study Published on 2021-11-012022-10-05 Journal: International immunopharmacology [Category] SARS, 임상, [키워드] 95% CI acute respiratory distress antiviral response association Biomarker cHIS. Clinical outcome Cohort Complication Concentration conducted control group correlated COVID-19 COVID-19 patient CRS cytokine releasing syndrome deficiency diagnosed with COVID-19 early stage eligible patient Hospital stay hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients Hyperinflammatory syndrome Infection Inflammation interquartile range IQR majority median median age morbidity Mortality Non-COVID-19 outcome outcomes Patient PCR-confirmed plasma zinc concentration Prevalence Prognostic marker retrospective risk robust SARS-CoV-2 severe SARS-CoV-2 significantly single-center Support syndrome tested the disease university hospital Zinc [DOI] 10.1016/j.intimp.2021.108163 PMC 바로가기 [Article Type] Observational Study
Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapyReview Article Published on 2021-10-202022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 바이오마커, 치료제, [키워드] adverse event Allogeneic Autoimmune diseases CAR-T Characteristics characterized chimeric antigen receptor circulating clinical feature clinical manifestations clinically COVID-19 CRS cytokine cytokine levels Cytokine release syndrome described disease disorder Efficacy elevated feature Fever Host human disease hyperinflammation Immunological disorders Immunotherapy incidence Infectious diseases Influenza Intervention life-threatening management mechanism organ dysfunction Pandemics pathway potential mechanism Regulation SARS-CoV signaling pathways Symptom syndrome systemic inflammatory therapy Toxicity [DOI] 10.1038/s41392-021-00764-4 PMC 바로가기 [Article Type] Review Article
COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-AnalysisSystematic Review Published on 2021-10-142022-10-30 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] ACE2 Achieved Affect age analyzed angiotensin antibody ARDS Blood Blood level calcidiol calcitriol caused clinical study correlation COVID-19 COVID-19 mortality CRS Cytokine release syndrome D3 dataset deficiency diabetes escape mutation Evidence Hospital admission identify immune defense Immune status immunodeficiency independent dataset Infection Inflammation IQR Linear regression median mitigate Mortality mortality risk outbreak Pearson correlation Prevent raising Rate Regression Renin reported Research Result retrospective cohort review SARS-CoV-2 SARS-COV-2 infection serum Seven severity Sex Side effect status suggested Topic Vaccinations virus infection Vitamin D Vitamin D3 was performed zero [DOI] 10.3390/nu13103596 PMC 바로가기 [Article Type] Systematic Review
Molecular Mechanism of the Anti-Inflammatory Action of HeparinArticle Published on 2021-10-032022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Action anti-inflammatory action anti-inflammatory agent applicability Autoimmune diseases bind binding biological activity Cell cellular receptor complex condition COVID-19 CRS Cytokine storm Cytokines heparin high affinity IFNγ IFNγ IL-6 Inflammation Inflammatory influence inhibit Interaction investigated LMWH low-molecular-weight heparin (LMWH) mechanism molecular dynamics molecular mechanism Molecular modelling nucleus overexpression phosphorylated resulting signalling pathway Stat1 stimulated translocation with COVID-19 [DOI] 10.3390/ijms221910730 PMC 바로가기 [Article Type] Article
Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis비정상적인 FLIP/STAT3 축에 의한 치명적인 사이토카인 방출 증후군Article Published on 2021-09-132022-09-10 Journal: Cell Death and Differentiation [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] approach caspase caspase-8 characterized clinical phenotype Control COVID-19 CRS cytokine Cytokine release syndrome Cytokines death detect dysregulated elevated expressed expression homolog immune disorders immune response immune responses Inflammation Inflammatory inflammatory pathology Inflammatory responses inflammatory state Intervention life-threatening Lung injury Lungs lymphopenia mice multiple organ dysfunction myeloid cell myeloid cells organ dysfunctions Organ failure organ failures pandemic pathogen invasion pathophysiology pathway Pathways Protein provoke regulated response SARS-CoV-2 pandemic STAT3 suppress syndrome the SARS-CoV-2 triggered Viral [DOI] 10.1038/s41418-021-00866-0 PMC 바로가기 [Article Type] Article
Tocilizumab in COVID-19: The Cerrahpaşa-PREDICT scoreCOVID-19의 Tocilizumab: Cerrahpaşa-PREDICT 점수Article Published on 2021-09-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 진단, [키워드] 28-day mortality acute respiratory syndrome administration benefit characterized Coronavirus-2 Course COVID-19 COVID-19 patient CRS Cytokine release syndrome D-dimer levels evaluated facilitate help humanized monoclonal antibody hyperinflammation ICU admission IL-6 receptor Infection laboratory parameter Laboratory parameters male median Mortality Negative predictive value outcome Patient performed Platelet Positive predictive value procalcitonin Proinflammatory cytokine receiving Retrospective study SARS-CoV-2 scoring system severe coronavirus disease significantly single-center suggested symptom onset syndrome The Cerrahpaşa-PREDICT score the disease therapeutic option therapeutic options Tocilizumab tocilizumab administration Treatment [DOI] 10.1016/j.jiac.2021.05.007 PMC 바로가기 [Article Type] Article
Evaluation of Vaccination Strategies to Compare Efficient and Equitable Vaccine Allocation by Race and Ethnicity Across TimeResearch Published on 2021-08-202022-10-30 Journal: JAMA Health Forum [Category] COVID-19, MERS, SARS, [키워드] 95% CI adverse outcome adverse outcomes age allocation analyzed approach Asian association black Black patient Care CDC center Combination conducted Control COVID-19 COVID-19 infection COVID-19 vaccine CRS data sets death deaths Deprivation distribution Effectiveness efficient estimate ethnic group Ethnic groups Ethnicity finding Health highest Hispanic Hospitalization hospitalizations household transmission identifying Importance individual Infection joint measure men morbidity and mortality objective participant Patient Point positive prevention proportion race Racial random Randomly reduce reducing reductions in Relevance Result risk risk of COVID-19 SARS-CoV-2 setting Strategy time transmissions vaccinate vaccination Vaccine were used white women [DOI] 10.1001/jamahealthforum.2021.2095 PMC 바로가기 [Article Type] Research