Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong’s omicron BA.2 wave: a retrospective cohort studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 1:1 Abstract Admission all-cause mortality analysed Antiviral Antiviral treatment authority calculated Chinese clinical benefit contraindication Control controls COVID-19 COVID-19 diagnosis Cox regression models Cycle threshold value Department diagnosis of SARS-CoV-2 Disease progression Effectiveness eligible evaluate event exclusion finding Follow-up for inclusion funding hazard ratio Hong Kong hospital hospitalised hospitalised patient HRs ICU admission IMV incidence rate Infection intensive care Invasive mechanical ventilation lower risk material Mild-to-moderate molnupiravir need for oxygen oral outcome outcomes Oxygen therapy pandemic Patient patients Primary outcome recipient Region registry renal required retrospective cohort retrospective cohort study RT-PCR SARS-CoV-2 SARS-COV-2 infection secondary outcome severe liver impairment Significant significantly shorter study period supplemental oxygen Support symptom onset therapy time translation viral burden virological outcome were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00507-2 [Article Type] Research article
SARS-CoV-2 viral load is associated with risk of transmission to household and community contactsSARS-CoV-2 바이러스 부하는 가정 및 지역사회 접촉자에게 전파될 위험과 관련이 있습니다.Article Published on 2022-08-052022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] 95% CI Adjusting association Asymptomatic Chain Reaction Chi-square chi-square tests close contact Community Contact Contact tracing cough COVID-19 Cycle threshold value Cycle threshold values described evaluate exposure Factor Factors Generalized high viral load index index case index cases investigated likelihood log Median viral load physical contact polymerase chain polymerase chain reaction positive pre-symptomatic proportion proportions public health measure public health measures quarantine recommendation Research risk factor Risk factors risk of transmission RNA copy Saliva SARS-CoV-2 transmission SARS-CoV-2 viral load scaled significantly test result tested tracing Transmission variant variants Viral load viral loads were used [DOI] 10.1186/s12879-022-07663-1 PMC 바로가기 [Article Type] Article
Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article
Intra-Familial Transmission Patterns of COVID-19 Infection among the Rural Residents of Ahmedabad, Gujarat, during an Epidemic of SARS-CoV-2 in IndiaArticle Published on 2022-07-222023-07-07 Journal: Japanese journal of infectious diseases [Category] COVID19(2023년), [키워드] Cycle threshold value Intra-familial transmission RT-PCR SARS-CoV-2 Viral load [DOI] 10.7883/yoken.JJID.2021.267
The importance of effect sizes when comparing cycle threshold values of SARS-CoV-2 variantsSARS-CoV-2 변이체의 주기 임계값을 비교할 때 효과 크기의 중요성Article Published on 2022-07-212022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] age Alpha variant Alpha VOC Analysis ANOVA Beta calculation carried clinical setting Combination Ct values cycle threshold Cycle threshold value effect size effect sizes estimate Gender group investigated magnitude marker mechanism mutations Occurrence onset of symptoms outpatients P-value p-values Patient positive sample post-hoc Retrospective study SARS-CoV-2 SARS-CoV-2 variant significant effect significantly statistical analysis study period Transmission variants of SARS-CoV-2 Viral load viral variant VoC were recorded wild type [DOI] 10.1371/journal.pone.0271808 PMC 바로가기 [Article Type] Article
Vaccination Is Associated With Shorter Time to Target Cycle Threshold Value in Patients With SARS-CoV-2 Omicron Variant백신 접종은 SARS-CoV-2 오미크론 변이가 있는 환자에서 목표 주기 역치 값까지 더 짧은 시간과 관련이 있습니다.Article Published on 2022-07-062022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Alter BBIBP-CorV booster vaccination Characteristics China Chinese CoronaVac coronavirus Course cycle cycle threshold Cycle threshold value disease course had no heterogeneous homologous inactivated Inactivated Vaccines infected with SARS-CoV-2 Infection Isolation life Limited male Mild symptom mild symptoms no difference omicron Omicron variant Patient patients patients with SARS-CoV-2 response retrospective cohort SARS-CoV-2 Science severe acute respiratory syndrome Coronavirus Shanghai Sinopharm Sinovac subject target the disease the mean time vaccination Vaccines value variant [DOI] 10.3389/fcimb.2022.943407 PMC 바로가기 [Article Type] Article
Risk factors for progression to acute respiratory failure after casirivimab and imdevimab administration: A retrospective study카시리비맙 및 임데비맙 투여 후 급성 호흡부전으로 진행되는 위험인자: 후향적 연구Article Published on 2022-07-012022-09-12 Journal: Respiratory investigation [Category] 진단, [키워드] Acute respiratory failure administration Admission analyzed antibody C-reactive protein Casirivimab casirivimab/imdevimab Characteristics Chest Chest computed tomography Chest radiograph city coronavirus disease COVID-19 Cycle threshold value detectable develop diabete diabetes Disease progression effective Factor Glucose hemoglobin Hiroshima Hospitalization independent interleukin-6 Logistic regression analysis Lymphocyte count median age monoclonal antibody multivariate Outpatient Patient patients with COVID-19 patients with diabete Pneumonia polymerase chain progressed progression reported Respiratory failure Retrospective study risk factor severe disease significantly therapy treated two group two groups [DOI] 10.1016/j.resinv.2022.04.005 PMC 바로가기 [Article Type] Article
Vaccine Effectiveness during Outbreak of COVID-19 Alpha (B.1.1.7) Variant in Men’s Correctional Facility, United States미국 남성 교정 시설의 COVID-19 알파(B.1.1.7) 변종 발병 시 백신 효과Review Published on 2022-07-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach B.1.1.7 coronavirus correctional facilities COVID-19 COVID-19 outbreak Cycle threshold value effective Effectiveness facility Genes incarcerated incarcerated persons Infection Moderna mRNA mRNA-1273 nucleocapsid occurred pandemic prisons public health qRT-PCR quantitative PCR Relative risk respiratory infections reverse transcription Reverse transcription quantitative PCR risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 United State United States USA Vaccine vaccine effectiveness variant variants viral loads Virginia viruses whole-genome sequencing zoonoses [DOI] 10.3201/eid2807.220091 PMC 바로가기 [Article Type] Review
Evaluation of Four Point of Care (POC) Antigen Assays for the Detection of the SARS-CoV-2 Variant OmicronSARS-CoV-2 변이체 오미크론 검출을 위한 4가지 진료 시점(POC) 항원 분석 평가Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Abbott Analysis analytical sensitivity Antigen assays Asymptomatic average Cell culture contributing to correlated Cycle threshold value ddPCR Delta delta variant detect detectable detection diagnostics digital PCR Dilution discrepancies discrepancy Ensuring evaluated Genome highest Infectious virus infectious virus titer limit limit of detection LOD log manuscript molecular N gene omicron Omicron variant POC Point point of care point-of-care positive quantified Rapid antigen tests Real-time PCR reduced replicate RNA SARS-CoV-2 specimen Spread swab sample symptomatic tested the SARS-CoV-2 vaccinated individuals variant variant of SARS-CoV-2 Viral viral stock viral stocks virus stock virus titer [DOI] 10.1128/spectrum.01025-22 PMC 바로가기 [Article Type] Article
High-Throughput Adaptable SARS-CoV-2 Screening for Rapid Identification of Dominant and Emerging Regional Variants우성 및 신흥 지역 변이의 신속한 식별을 위한 처리량이 높은 적응형 SARS-CoV-2 스크리닝Article Published on 2022-06-072022-09-11 Journal: American journal of clinical pathology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age approach Care Chain Reaction coronavirus Cycle threshold value Delta delta variant detect detection dominant Dynamic system E484K Effectiveness genotyping Health Health care Health care system health system highlight hospital identification IMPROVE Increases Infection median pandemic polymerase chain reaction Rapid reactive reduced Regional RT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened Screening screening program selective Sequencing severe acute respiratory syndrome Coronavirus severe disease strain Surveillance Targeted testing Transmissibility utility variant Variant identification variant of concern variant screening variants viral sequence [DOI] 10.1093/ajcp/aqab212 PMC 바로가기 [Article Type] Article