SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19인간 iPSC 유래 심장 세포의 SARS-CoV-2 감염은 COVID-19 환자의 심장에서 세포변성 특징을 반영합니다Reports Published on 2021-03-152022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations Asymptomatic Autopsy autopsy specimens cardiac damage cause Cell consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytopathic damage dysfunction exposure feature heart Human Infection leads morphologic features Morphological nuclear offer Pathogenesis Patient patients patients with COVID-19 platform raise reflect reflected respiratory robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases specimen stem cell transcriptomic [DOI] 10.1126/scitranslmed.abf7872 PMC 바로가기 [Article Type] Reports
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication인돌 부분이 있는 소분자 화합물은 SARS-CoV-2의 주요 프로테아제를 억제하고 바이러스 복제를 차단합니다.Article Published on 2021-01-282022-09-10 Journal: Nature Communications [Category] 치료기술, 치료제, [키워드] active site Amino acid amino acid residues anti-SARS-CoV-2 Antimicrobials Antiviral Antiviral effect assays block Compound covalent bond cytopathic cytotoxicity detectable exhibit form immunocytochemistry in vitro In vitro assay indole indoline inhibit inhibitor lead M pro polar interaction polar interactions protease Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease Structural analysis synergism synergistic the SARS-CoV-2 Therapeutics Viral virus virus replication X-ray [DOI] 10.1038/s41467-021-20900-6 PMC 바로가기 [Article Type] Article
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2Pharmacology Published on 2021-01-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] against SARS-CoV anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity antiviral activity approach approved approved drug approved drugs carried Chlorprothixene clinical trial Compound compounds COVID-19 cytopathic Cytopathic effect drug Drug repurposing drug repurposing and discovery drugs Ebola virus Effect FDA-approved drug HTS identify Infectious disease new drug combination Quantitative reported repurposing resource SARS-CoV-2 Screen Treatment [DOI] 10.3389/fphar.2020.592737 PMC 바로가기 [Article Type] Pharmacology
Findings of Hepatic Severe Acute Respiratory Syndrome Coronavirus-2 Infection간중증급성호흡기증후군 코로나바이러스-2 감염 소견Article Published on 2021-01-012022-09-12 Journal: Cellular and molecular gastroenterology and hepato [Category] SARS, 진단, [키워드] absence acute respiratory syndrome analyzed Apoptosis apoptotic bodies cell injury cellular change Clinical course coronavirus disease Coronavirus-2 COVID-19 cytopathic Endotheliitis finding formalin-fixed paraffin-embedded hepatic Hepatitis histologic histology hybridized In situ hybridization increasingly Inflammatory Injury intrahepatic light microscopy liver Liver Biopsy Liver injury liver tissue Liver transplantation majority Microscopy Non-hepatotropic Virus occur other organs Patient patients probe processed rejection respiratory S gene SARS-CoV-2 SARS-CoV-2. severe COVID-19 severity [DOI] 10.1016/j.jcmgh.2020.09.015 PMC 바로가기 [Article Type] Article
The application of direct viral cytopathic hypothesis to design drug trials in the battle against COVID-19COVID-19와의 전쟁에서 약물 시험을 설계하기 위해 바이러스 직접 세포병증 가설의 적용Article Published on 2020-12-012022-09-11 Journal: Daru : journal of Faculty of Pharmacy, Tehran Univ [Category] SARS, 임상, 치료제, [키워드] 2019 ACE-2 ARDS cascade caused cellular Coagulopathy Complication coronavirus coronavirus disease Coronavirus disease of 2019 (COVID-19) COVID-19 cytopathic death Direct Direct viral cytopathy disease drug trial Efficacy events explain explained focus host receptor Hypothesis in vitro in vivo majority medication mortalities Pathogenesis Potential potential therapies Potential therapies. SARS-CoV-2 shown systemic systemic inflammatory the disease Therapies translate Trial Viral [DOI] 10.1007/s40199-020-00368-3 PMC 바로가기 [Article Type] Article
A persistently replicating SARS-CoV-2 variant derived from an asymptomatic individualResearch Published on 2020-09-232022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] absence accumulating Amount analyzed approach Asymptomatic asymptomatic infection Brescia changed Characteristics circulating Clinical characteristics COVID-19 COVID-19 epidemic cytopathic Cytopathic effect Epidemic Evolution Evolution of SARS-CoV-2 Genetic Genetic variation healthcare worker highlight Host human host identification in silico analysis individuals Infection Italian Italy Mild Non-synonymous nucleotide mutations nucleotide position ORF1ab outbreak pathogenicity phenotypic Proteins quantitative PCR released Replication Result SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant selection process Sequencing shown specimen Substitution sustained Swab the epidemic variant Vero E6 Vero E6 cell VERO E6 cells Viral load viral mutation viral variant virus virus isolate Virus persistence was performed Whole genome sequencing [DOI] 10.1186/s12967-020-02535-1 PMC 바로가기 [Article Type] Research
Evaluation of SARS‐CoV‐2 neutralizing antibodies using a CPE‐based colorimetric live virus micro‐neutralization assay in human serum samples인간 혈청 샘플에서 CPE 기반 비색 생 바이러스 미세 중화 분석을 사용한 SARS-CoV-2 중화 항체 평가Research Article Published on 2020-05-172022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] Adenovirus antibody concentration borderline China comparable CR3022 cytopathic diagnostic ELISA epidemiological Epidemiology evaluated Human monoclonal antibody human serum Humoral immunity immunology immunosorbent Influenza Italian Live virus microneutralization neutralization Neutralization assay Neutralizing antibodies neutralizing antibody objective optical microscope outbreak pandemic performed positive provided SARS Coronavirus SARS‐CoV‐2 SARS‐CoV‐2 virus sensitivity Serological assay serological assays serum sample serum samples Siena spectrophotometer Strains Subjective tested University of Siena Vaccine Virology virus wild type [DOI] 10.1002/jmv.25986 PMC 바로가기 [Article Type] Research Article