The Role of Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug DesignMicrobiology Published on 2021-12-242022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] alleviate Apoptosis ATF6 autophagy cause Cell complex interplay coronavirus Coronavirus infection Coronavirus replication cytoplasm drug drug target drug targets Endoplasmic reticulum endoplasmic reticulum stress ER stress homeostasis host innate immunity Human Infection innate immune response knowledge microRNA modulate occur pathogen Pathogenesis regulate Replication reported response role signaling pathways threat unfolded protein response unfolded protein response (UPR) UPR [DOI] 10.3389/fmicb.2021.808593 PMC 바로가기 [Article Type] Microbiology
Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID제2형 당뇨병, 후기 발병 알츠하이머병 및 장기 코로나에서 엽산 매개 단일 탄소 대사 장애Review Published on 2021-12-232022-09-10 Journal: Medicina [Category] SARS, 유전자 메커니즘, [키워드] Abnormalities Alzheimer’s disease Alzheimer’s disease biochemical Biomarker biosynthetic biosynthetic pathways carbon clinical disease COVID COVID-19 cytoplasm developmental diabetes Diabetes Mellitus Diseases elevated epigenetics folate functional homocysteine hyperhomocysteinemia Impaired incorporation knowledge Long Long COVID mechanism metabolic network metabolic pathway metabolic pathways metabolism Mitochondria MTHFR gene mutations nucleus nutritional B vitamin deficiencies PASC pathology pathway progression Repurposed drugs responsible SARS-CoV-2 Stress the reader Therapeutics Treatment Type type 2 diabete Type 2 diabetes mellitus Vitamin vitamins [DOI] 10.3390/medicina58010016 PMC 바로가기 [Article Type] Review
Coronavirus RNA Synthesis Takes Place within Membrane-Bound SitesArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 229E bromouridine bronchitis cause Cell conserved coronavirus cytoplasm dsRNA host cell host cells IBV IBV infection imperative Infection Infectious Bronchitis Virus membrane membrane-bound organelle PDCoV positive produced proportion Replication Replication organelle RNA RNA viruses SARS-CoV-2 shown significantly Site synthesis understanding viral life cycle Viral RNA viral RNA synthesis virus [DOI] 10.3390/v13122540 PMC 바로가기 [Article Type] Article
Rational preparation and application of a mRNA delivery system with cytidinyl/cationic lipid시티디닐/양이온 지질을 사용한 mRNA 전달 시스템의 합리적인 준비 및 적용Article Published on 2021-12-102022-09-11 Journal: Journal of controlled release : official journal o [Category] SARS, 치료기술, [키워드] acetamide Adaptive immune response adverse event approved Cationic lipid cell immunity CLD Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA vaccine cytoplasm Efficacy and safety electrostatic encapsulate Formulation H-bonding immunized mice induce interactions intramuscular Lipid lipids Lipoplexes Messenger RNA Mild Moderna mRNA mRNA delivery. mRNA vaccines Neutral Neutralizing antibodies neutralizing antibody nucleotide outbreak Pfizer-BioNTech propanoate reported robust shown single nucleotide stimulate therapy [DOI] 10.1016/j.jconrel.2021.10.023 PMC 바로가기 [Article Type] Article
A Bacterial Cell-Based Assay To Study SARS-CoV-2 Protein-Protein InteractionsResearch Article Published on 2021-11-162022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome amino acid substitution Bacterial Cell circulating SARS-CoV-2 variants coronavirus coronavirus disease COVID-19 cytoplasm detect disrupt dissect domain Effect encoded protein encoded proteins Escherichia coli eukaryotic examined facilitate feasibility Genetic Health Interaction interactions mutations PPI Protein protein interactome protein-protein interaction protein-protein interactions Proteins proteome RBD RBD-ACE2 reducing SARS-CoV-2 Spike protein surface receptor the SARS-CoV-2 therapeutic this system Treatment two-hybrid analyses utility Viral protein [DOI] 10.1128/mBio.02936-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export blockArticle Published on 2021-11-012022-10-29 Journal: RNA (New York, N.Y.) [Category] COVID-19, MERS, SARS, [키워드] Antiviral antiviral response biogenesis caused cytoplasm cytoplasmic Degradation dissemination early stage elevated expression Genes hallmark Host host mRNA IFN immune response inhibit inhibited Innate immunity interferon IRF3 limit mammalian mRNA mRNA decay mRNA export mRNAs nucleus Patient performed Protein Regulatory RNA RNase RNase L SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 replication second serum severe COVID-19 disease Signaling the interferon the SARS-CoV-2 Transcription transcription factor transcriptional translocation Transport Trigger type I Type III IFN viral replication widespread [DOI] 10.1261/rna.078923.121 PMC 바로가기 [Article Type] Article
S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategiesResearch Article Published on 2021-10-252022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antiviral antiviral activity assist association binding broad inhibitor C-terminal C-terminal region catalytic site catalytically caused cofactor complex coronavirus CpG cysteine cytoplasm Degradation dependent on determinant dinucleotide distribution domain element Endoplasmic reticulum Factors highlight HIV-1 Human immunodeficiency virus hydrophobic in viral inactive Interaction isoform KHNYN lack membrane membranes Microscopy modulate motif N-terminal RNA-binding domain nucleus PARP physical plasma membrane polymerase post-translational modification Prevent Protein provide recruitment regulate replicate Replication required residue restored RNA RNA virus RNAs SARS-CoV-2 Structure subcellular translation TRIM25 type I Vesicle viral pathogens Viral RNA virion virus virus replication ZAP [DOI] 10.1371/journal.ppat.1009726 PMC 바로가기 [Article Type] Research Article
Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19?Review Published on 2021-10-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] affecting Cell cell death component contributing to COVID-19 cytoplasm damage erastin Fatty acid Ferroptosis Glutamate GPX4 GSH GSH-GPX4 axis inactivation inducer inhibit Intervention iron kidney leading lipid peroxides Manifestations metabolism molecular mechanism Multiorgan Multiorgan damage multiple organs Myocardial myocarditis oxidative stress pathology Polyunsaturated precursor Process programmed cell death promoted reactive oxygen specy reduce reported SARS-CoV-2 SARS-COV-2 infection Shock upregulation [DOI] 10.3390/antiox10111677 PMC 바로가기 [Article Type] Review
Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoproteinResearch Article Published on 2021-10-202022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS, [키워드] Analysis antibody antibody engineering C-terminal conformational coronavirus protein COVID-19 COVID-19 pandemic CTD, C-terminal domain of the nucleoprotein cytoplasm detect develop development diagnostic domain domains ELISA epitope HDX-MS, hydrogen deuterium exchange–mass spectrometry human coronavirus human coronaviruses hydrogen hydrogen-deuterium exchange immunized immunoassay Immunochemistry infected cell N protein N-terminal N, nucleoprotein nanobodies nasal swabs NTD, N-terminal domain of the nucleoprotein Nucleolus nucleoprotein phage display recognize recognizing required SARS-CoV-2 SARS-CoV-2 N protein Seven single domain antibodies specific antibody Spectrometry the SARS-CoV-2 the SARS-CoV-2 virus tissues variant viral RNA synthesis [DOI] 10.1016/j.jbc.2021.101290 PMC 바로가기 [Article Type] Research Article
Self-Replicating RNA Viruses for Vaccine Development against Infectious Diseases and CancerReview Published on 2021-10-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Administered alphavirus animal models applied approval approved Brain Cancer Cell clinical clinical settings cytoplasm development DNA dose Ebola virus Ebola virus disease evaluated expression levels extreme Hepatitis B virus HIV immune response immune responses Infectious disease Infectious diseases Influenza virus lung Melanoma mRNA ovarian Particles pathogen plasmids Prostate cancer protection protein expression replicate RNA RNA vaccine RNA viruses RNA-dependent RNA polymerase robust SARS-CoV-2 vaccine self-replicating RNA viruses shown significantly lower Single-stranded RNA viruses surface protein transgene translation Trial tumor antigen tumor regression Vaccine Vaccine development Vaccines Viral vector virus [DOI] 10.3390/vaccines9101187 PMC 바로가기 [Article Type] Review