COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunctionCOVID-19는 내피 장벽 기능 장애를 직접 유도하는 히알루로난 단편을 생성합니다Research Article Published on 2021-09-082022-09-12 Journal: JCI Insight [Category] 진단, [키워드] activity analyzed CD44 circulating circulation Clinical severity Complication contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critical illness damaged Degradation degrade disease dysfunction dysregulated endothelial Endothelial cell enzyme Enzymes Evidence exacerbating Extracellular matrix functions generate glycobiology glycocalyx glycosaminoglycan Hyaluronan hyaluronidase induce Inflammatory cytokine Injury moderate moderate to severe morbidity Organ failure pathologic pathology patients with COVID-19 plasma Protective provide pulmonary regulate released Sepsis Severity of disease significantly Vascular Vascular Biology Vascular injury [DOI] 10.1172/jci.insight.147472 PMC 바로가기 [Article Type] Research Article
Repurposing proteases: An in-silico analysis of the binding potential of extracellular fungal proteases with selected viral proteinsResearch article Published on 2021-09-012022-10-05 Journal: Bioresource Technology Reports [Category] 신약개발, [키워드] Analysis Antiviral binding binding energy COVID degrade docking drugs enzyme Enzymes Extracellular fungal identify in-silico infectious agents microbial Penicillium protease Protein repurposing resource selected tap the SARS-CoV-2 virus therapeutic therapeutic agent Viral protein viral spike [DOI] 10.1016/j.biteb.2021.100756 [Article Type] Research article
Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate ImmunityResearch Article Published on 2021-08-102022-10-29 Journal: mBio [Category] COVID-19, [키워드] 2-5A activate Activation activities AKAP7 Antiviral antiviral effects antiviral response cellular cleave cleaved coronavirus CoVs degrade enzyme Enzymes evolutionary relationship IFN Innate Innate immunity interferons investigated limit mammalian MERS-CoV MHV Middle East mouse CoV mouse hepatitis virus NS2 NS4b OAS phosphate producing Protein Regulation respiratory syndrome coronavirus RNA RNase RNase L rotavirus shown the interferon tissue damage trimer two-histidine phosphoesterase viral escape viral infection while [DOI] 10.1128/mBio.01781-21 PMC 바로가기 [Article Type] Research Article
Autoantibodies stabilize neutrophil extracellular traps in COVID-19자가 항체는 COVID-19에서 호중구 세포외 트랩을 안정화합니다Research Article Published on 2021-08-092022-09-10 Journal: JCI Insight [Category] MERS, SARS, 진단, 치료제, [키워드] Adaptive immunity antibodies antibody associations autoantibodies autoantibody Autoimmunity circulating clearance contribute correlation COVID-19 COVID-19 sera D-dimer Degradation degrade demonstrated determine Efficiency fraction function functional greater healthy control healthy controls Hospitalized IgG IgG and IgM IgM immunopathology impair individual inherent inverse correlation Level mechanical ventilation NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils oxygen oxygen supplementation Oxygenation Patient patients purified required sera serum severe COVID-19 Thromboinflammation variety with COVID-19 [DOI] 10.1172/jci.insight.150111 PMC 바로가기 [Article Type] Research Article
The Molecular Interplay between Human Coronaviruses and AutophagyReview Published on 2021-08-072022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome aggregates autolysosome autophagosome autophagy caused Complete conserved Coronaviral coronavirus Coronavirus disease 2019 COVID-19 degrade Diseases example HCoV-NL63 HCoV-OC43 Host Human human coronavirus Interaction life-threatening lysosome membrane MERS-CoV Mild molecular molecular mechanisms MOST multiple coronaviruses neutralize other coronavirus Pathogens pathway Protein SARS-CoV SARS-CoV-2 Symptoms therapy Vesicle virus viruses worldwide pandemic [DOI] 10.3390/cells10082022 PMC 바로가기 [Article Type] Review
Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host CellsPerspectives Published on 2021-08-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] alveolar Analysis Antiviral antiviral properties antiviral property Apoptosis Cell cellular cellular miRNA Complication COVID-19 CoVs cytoplasm cytosol Defense degrade Endothelial cell endothelial cells expression Host host cell host miRNAs Hypothesis identify involved lung microRNA miRNA miRNAs modulate modulated modulating nutriepigenomic performed polyphenol polyphenols Prevent prevention Regulation RNA SARS-CoV-2 SARS-CoV-2 RNA single-stranded RNA virus target gene translation type 2 pneumocyte viral infection Viral proteins viral replication Viral RNA virus [DOI] 10.14336/AD.2021.0223 PMC 바로가기 [Article Type] Perspectives
Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunizationResearch Article Published on 2021-07-282022-10-28 Journal: Science Advances [Category] Coronavirus, SARS, [키워드] antibodies antibody approach Critical degrade driven by elicit elicited epitope epitope mapping Epitopes glycoprotein HIV immunization immunogen Influenza iterative Microscopy Neutralizing Neutralizing antibodies neutralizing antibody polyclonal prefusion conformation Protein protein subunit vaccine provide responses RSV SARS-CoV-2 subunit Subunit vaccine target trimer trimeric Vaccine Vaccine design variety viral surface virus while [DOI] 10.1126/sciadv.abh2791 PMC 바로가기 [Article Type] Research Article
Cell Analysis from Dried Blood Spots: New Opportunities in Immunology, Hematology, and Infectious DiseasesResearch Article Published on 2021-07-182022-10-28 Journal: Advanced Science [Category] COVID-19, SARS, [키워드] analyses Analysis Biomarker Biomedical research Blood blood cell buffer CD169 Cell cells cellular compartments cellular molecule common coronavirus 2 Cytometry degrade described Dried blood spots elution buffer facilitate Flow healthcare hematology implication Infection Infectious disease Laboratory leucocyte majority management mRNA mRNA expression New opportunity Patient performed permeabilized preserved Rapid red blood cell resource respiratory SARS‐CoV‐2 shaking staining Support temperature variety while [DOI] 10.1002/advs.202100323 PMC 바로가기 [Article Type] Research Article
Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch toleranceArticle Published on 2021-07-132022-10-04 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] antiviral drug antiviral therapeutics approach B.1.1.7 cellular circumvent CRISPR CRISPR-Cas systems D614G degrade demonstrated described dominant variant effector Efficiency genomic highlight host immunity impair Interaction mammalian cell mammalian cells molecular Mutagenesis mutant mutated pathogenic viruses Prevent Region replication-competent SARS-CoV-2 Resilience RNA RNA transcript RNAi RNAi therapy SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 replication SARS-CoV-2 strain SARSCoV-2 single-nucleotide specificity spike subgenomic RNAs suppress suppresse Synthetic biology the Spike Tolerance transcript variant variants of concern viral escape viral replication [DOI] 10.1038/s41467-021-24577-9 PMC 바로가기 [Article Type] Article
Expression of Human ACE2 N-terminal Domain, Part of the Receptor for SARS-CoV-2, in Fusion With Maltose-Binding Protein, E. coli Ribonuclease I and Human RNase AMicrobiology Published on 2021-06-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] E. coli ribonuclease I (RNase I) ACE2 ACE2 protein Antiviral antiviral agent bacterial cell Cartoon cleaving degrade dsRNA E. coli enzyme evaluated expressed expression fusion fusion protein Genome Human human ACE2 receptor human RNase A-ACE2NTD fusion in vitro Inclusion Infection Membrane proteins N-terminal N-terminal domain Nucleocapsid proteins Part Protein Proteins provide purified receptor ribonuclease RNA RNA degradation RNase RNase I-ACE2NTD fusion RNase III RNases SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 virus single-stranded soluble fraction Strains viral genome viral nucleic acids virions [DOI] 10.3389/fmicb.2021.660149 PMC 바로가기 [Article Type] Microbiology