A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients특정 저밀도 호중구 개체군은 입원한 COVID-19 환자의 과응고 및 질병 중증도와 상관관계가 있습니다Research Article Published on 2021-05-102022-09-10 Journal: JCI Insight [Category] SARS, 바이오마커, [키워드] activated acute respiratory distress acute respiratory distress syndrome ARDS Asymptomatic Bronchoalveolar lavage fluid cause CD16 CD38 CD44 Cell changed circulating circulation clinical disease Coagulation Coagulopathy contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Critical disease CXCR3 cytokine cytokine production D-dimer demonstrated develop disease severity disease status exhibiting expressing expression ferritin Frequency hospitalized COVID-19 patient IL-6 Immune cell immune cells immunology Inflammatory life-threatening low-density marker Mild MONITOR neutrophil Neutrophil extracellular traps Neutrophils Patient patients with COVID-19 phagocytic capacity Platelets Pneumonia Prognosis progression proinflammatory gene respiratory respiratory distress SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 severe COVID-19 subset Symptoms syndrome systemic inflammation These cells TNF-α upper respiratory tract venous Viral viral pathogen Viral pneumonia with COVID-19 [DOI] 10.1172/jci.insight.148435 PMC 바로가기 [Article Type] Research Article
Experience of the use of hydroxychloroquine on patients with COVID-19: A perspective on viral load and cytokine kineticsCOVID-19 환자에 대한 하이드록시클로로퀸 사용 경험: 바이러스 부하 및 사이토카인 동역학에 대한 관점Article Published on 2021-05-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 치료기술, 치료제, [키워드] active against Anti-inflammatory anti-inflammatory effect Antiviral approved checked Clinical use Complication coronavirus Course COVID-19 COVID-19 diagnosis cytokine cytokine profile detectable disease status Elevation experience HCQ Hydroxychloroquine IL-17 Infection Inflammatory interferon Interferon-gamma interleukin marker Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 MONITOR Patient patients performed Perspective potential therapeutic target preliminary report Prolonged receiving remained respiratory specimen respiratory specimens SARS-CoV-2 SARS-CoV2 specific treatment symptom onset the mean treated Treatment use of hydroxychloroquine Viral load virus [DOI] 10.1016/j.jfma.2020.08.022 PMC 바로가기 [Article Type] Article
Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection새로운 ELISA 프로토콜은 기존 SARS-CoV-2 반응성 항체를 풍토성 코로나바이러스 면역 및 연령과 연결하고 다중 매개변수 감지를 통해 급성 COVID-19의 향상된 혈청학적 식별을 나타냅니다.Immunology Published on 2021-04-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Abbott Abbott test acute COVID-19 added age antibodies antibody Antibody detection antibody levels approved assays binding domain buffer circulating coated coronavirus COVID-19 COVID-19 pandemic detection Dilution disease disease status Economy ELISA ELISA protocol Endemic EUA HIV Hospitalized identification IgA IgA antibodies IgA antibody IgA level IgA levels IgG IgM Immunity immunoassay impacted implication Improved infected individuals information life magnitude measurement Microparticle novel nuance nuances nucleocapsid (N) nucleocapsid protein optical densities optical density platform pre-existing immunity RBD reactive reagents receptor binding domain (RBD) reported SARS-CoV-2 SARS-CoV-2 IgM SARS-CoV-2 infected individual SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody sensitive serologic serology serology test significantly lower SLE specific IgM standard curve Strains subject subjects Symptoms utility Viral protein Viral proteins virus transmission [DOI] 10.3389/fimmu.2021.614676 PMC 바로가기 [Article Type] Immunology
The impact of COVID-19 in the management of AL amyloidosis and Immunoglobulin Deposition Disease: A single-center experienceAL 아밀로이드증 및 면역글로불린 침착 질환 관리에 대한 COVID-19의 영향: 단일 센터 경험Article Published on 2021-03-012022-09-12 Journal: European journal of haematology [Category] SARS, 진단, [키워드] AL amyloidosis analyzed Care Cell Clinical characteristics collected Complication COVID-19 COVID-19 pandemic deposition disease disease status disorder epidemiological immune immune defects Immunoglobulin immunoglobulin deposition disease Local management modifications organ outbreak pandemic Patient patients died plasma Plasma cell disorder receiving required single-center tested Treatment WHO [DOI] 10.1111/ejh.13552 PMC 바로가기 [Article Type] Article
Impact of COVID-19 pandemic on rheumatoid arthritis from a Multi-Centre patient-reported questionnaire survey: influence of gender, rural-urban gap and north-south gradientObservational Study Published on 2021-02-012022-10-05 Journal: Rheumatology International [Category] SARS, 임상, [키워드] addition age Arthritis Care changes in clinics college conducted Contact coronavirus Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 pandemic determine disease disease status female Gender had more Health Health status Hydroxychloroquine Impact Infection information initiated majority male medication Multi-centre North-south gradient pandemic Patient Patient-reported questionnaire patients provided questionnaire regions reported Rheumatoid rheumatoid arthritis rheumatologist rheumatology significantly socio-demographic subsequent Treatment urban WhatsApp [DOI] 10.1007/s00296-020-04736-9 PMC 바로가기 [Article Type] Observational Study
Severity of COVID-19 at elevated exposure to perfluorinated alkylatesResearch Article Published on 2020-12-312022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval accumulate adjusted age Analysis association chronic disease Concentration contribute coronavirus disease Course COVID-19 Deceased Demographic variables determine Diagnosis disease disease severity disease status elevated European FIVE health information Hospitalized increased risk intensive care Logistic regression Lungs males measure Odds ratio outcome PFAS plasma sample Population Result SARS-COV-2 infection severity study population subject the disease was obtained [DOI] 10.1371/journal.pone.0244815 PMC 바로가기 [Article Type] Research Article
Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors건강 및 천식, COPD, 비만, 고혈압 및 COVID-19 위험 요소의 조직 및 면역 세포에서 ACE2, CD147, CD26 및 기타 SARS-CoV-2 관련 분자의 분포Article Published on 2020-11-012022-08-31 Journal: Allergy [Category] SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] ACE2 Adults age Altered analyzed Asthma atopic dermatitis B cells BAL Blood BMI bronchial epithelial cells Bronchoalveolar lavage fluid BSG caused CD147 CD26 CD4 CD8 clinical presentation co-expression coexpressed Comorbidity contribute COPD correlated COVID-19 COVID-19 children database DCs disease disease status DPP4 epithelial epithelial cells expression expression profile Factor Gender Gene Expression Health healthy children healthy subject healthy subjects human cell human cells hypertension Immune cell immune cells Infection involved lung male material molecular Monocytes mononuclear cell mononuclear cells morbidity Mortality Neutrophils NK cells Novel coronavirus novel coronavirus SARS-CoV-2 obesity Patient PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells plasmablasts PPIA PPIB primary human bronchial epithelial cells primary human cell primary human cells receptor reported risk factor Risk factors RNA sequencing SARS receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors severity skin skin biopsies smoking T cell T cells the disease the SARS-CoV-2 tissue tissues TMPRSS2 were expressed Whole blood [DOI] 10.1111/all.14429 PMC 바로가기 [Article Type] Article
Interpersonal Violence during the COVID-19 Lockdown Period in Nepal: A Descriptive Cross-sectional StudyOriginal Article Published on 2020-10-312022-10-30 Journal: JNMA: Journal of the Nepal Medical Association [Category] Coronavirus, MERS, SARS, [키워드] domestic violence interpersonal violence substance abuse addition adverse event alcohol Analysis Consensus convenience sampling COVID-19 cross-sectional disease status Factors female Government group identification identify include individuals lockdown male management Mental Nepal Occurrence pandemic participant Period Prevalence reported socio-demographic spread of COVID-19 Statistical tests Stress stressful situations Substance use survivor the WHO Violence [DOI] 10.31729/jnma.5499 PMC 바로가기 [Article Type] Original Article
Risk factors and outcome of COVID-19 in patients with hematological malignanciesResearch Published on 2020-08-252022-10-31 Journal: Experimental Hematology & Oncology [Category] COVID-19, [키워드] 95% CI 95% confidence interval age Allogeneic Analysis autologous Blood C-reactive protein cancer patient Cell Corticosteroid COVID-19 COVID-19 in patient COVID-19 mortality CRP defined disease status driven by Factor Hematological malignancies Hematological malignancy hospital immune Inflammation laboratory-confirmed SARS-CoV-2 infection large cohort Logistic regression low dose lower mortality multicenter neutropenia Older age outcome overall mortality parameter Patient PCR assay pediatric performance status recipient Result retrospective severe COVID-19 Spain Spanish Stem cell transplantation therapy Treatment [DOI] 10.1186/s40164-020-00177-z PMC 바로가기 [Article Type] Research
Does severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cause orchitis in patients with coronavirus disease 2019 (COVID-19)?Research Article Published on 2020-08-112022-10-28 Journal: Arab Journal of Urology [Category] COVID-19, [키워드] acute respiratory syndrome age all age group association clinical symptom collected coronavirus coronavirus disease Coronavirus-2 COVID-19 disease severity disease status enzyme excluded Follow-up group hospital Hypothesis identify immunodeficiency information IRB male molecular observé orchitis Patient patients patients with COVID-19 polymerase chain Prevalence protease retrospective review SARS-CoV-2 Serine Symptom transcriptase transmembrane White blood cell with COVID-19 [DOI] 10.1080/2090598X.2020.1798862 PMC 바로가기 [Article Type] Research Article