Evaluation of Virulence in Cynomolgus Macaques Using a Virus Preparation Enriched for the Extracellular Form of Monkeypox VirusArticle Published on 2022-09-092023-06-09 Journal: Viruses [Category] Fulltext, 원숭이두창, [키워드] countermeasures dissemination extracellular virion Model Monkeypox morphogenesis nonhuman primates orthopoxvirus smallpox Transmission Viremia [DOI] 10.3390/v14091993 PMC 바로가기
How Do Anti-SARS-CoV-2 mRNA Vaccines Protect from Severe Disease?Article Published on 2022-09-082022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] adaptive alveolar alveolar macrophage Alveolar macrophages antiviral immunity approach benefit consequence COVID-19 Cytokine storm develop diffusion disease dissemination Efficacy elicited epithelial cell expected experimental evidence Extracellular Factor feature Host immune response immune function inhibitory effect intramuscularly Macrophage mechanism messenger mRNA mRNA vaccine mRNA vaccines mucosa other tissue outcome Pathogenesis Prophylaxis Protein Quantitative respiratory respiratory symptom respiratory tracts SARS-CoV-2 severe disease spike Spread TGF-β the cytokine storm upper respiratory tracts Vaccine viral replication virus while [DOI] 10.3390/ijms231810374 PMC 바로가기
Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-viralsArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 binding affinity angiotensin-converting enzyme 2 Anti-viral antivirals binding biosynthetic build candidate Cell D614G mutation displaying dissemination EC50 EC50 value fusion protein generate hamsters high stability in vitro Infection Interaction mitigate motif nasal nasal epithelium neutralisation activity neutralization neutralized Omicron variants overlapping promote Protein protein sequence proximal RBD Receptor binding domain recognizing reduced Replication SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants selected targeting the RBD the SARS-CoV-2 trivalent virus virus entry [DOI] 10.1371/journal.ppat.1010799 PMC 바로가기
Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infectionArticle Published on 2022-09-022022-11-16 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] Acinetobacter acquisition antimicrobial drug Bacteremia Bacterial bloodstream infection caused change characteristic COVID-19 pandemic Critical curtail dissemination essential nutrient evaluated exhibited expand expression expression pattern feasible gene encoding Gene Expression Gram-negative bacteremia growth Health healthcare homeostasis Host host gene expression Immunity impairment include induce Infection inhibit inhibiting innate immune response involved lack Lcn2 lipocalin-2 MDR mechanism mice Mortality multidrug resistant multifactorial organ organ-specific pathogen Pneumonia Prevalence proliferation Protective Protein required reveal robust S100A8 S100A9 secondary bacterial pneumonia sequestering survival target therapeutic tissues Transcription transcriptional Treatment upregulated ventilated patient Ventilator-associated pneumonia were infected World Health Organization [DOI] 10.1371/journal.ppat.1010809 PMC 바로가기
Harvest for Health, a Randomized Controlled Trial Testing a Home-Based, Vegetable Gardening Intervention Among Older Cancer Survivors Across Alabama: An Analysis of Accrual and Modifications Made in Intervention Delivery and Assessment During COVID-19Research article Published on 2022-09-012022-10-05 Journal: Journal of the Academy of Nutrition and Dietetics [Category] 임상, [키워드] Analysis anticipated approach assessment assigned Baseline assessment Breast cancer Cancer Controlled COVID-19 COVID-19 pandemic cross-over delivery diet dissemination Effect eligible enrolled Enrollment Evidence female functional gardening Harvest Health IMPROVE indicated Intervention Modification not differ objective Older Older adults outcome outcome measure participant performed physical physical activity Physical function populations primary end point protocol Quality of life Randomized Randomized controlled trial Randomly RCT recruited recruitment reported Result screened significantly higher survival survivor Survivors survivorship T Test Testing Trial vegetable were used widespread [DOI] 10.1016/j.jand.2022.05.005 [Article Type] Research article
Dissemination of Multiple Drug-Resistant Shigella flexneri 2a Isolates Among Pediatric Outpatients in Urumqi, Chinaarticle Published on 2022-08-312024-09-01 Journal: Foodborne Pathogens and Disease [Category] 세균성이질, [키워드] dissemination resistance Shigella flexneri [Article Type] article
The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemiaArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] accelerated antibody baseline binding binding activity binding antibody Characteristics clearance COVID-19 COVID-19 disease COVID-19 disease severity Critical death defined development disease disease severity dissemination effective Evolution examined FcγR feature function highlight humoral humoral immune response IgG IgG3 immune immune clearance immune function Immune profile independent Kinetics Longitudinal data longitudinal data modeling maturation monoclonal Mortality natural infection neutralization outcome persistence persistent persistent SARS-CoV-2 plasma viremia plasma predict progression provide SARS-CoV-2 SARS-CoV-2 replication severe COVID-19 Specificities subunit system serology viral clearance viral replication Viremia [DOI] 10.1128/mbio.01577-22 PMC 바로가기
Impact of COVID-19 pandemic on screening and diagnosis of patients with prostate cancer: a systematic review protocolArticle Published on 2022-08-262022-11-15 Journal: BMJ Open [Category] SARS, 바이오마커, 치료기술, [키워드] Antigen approval authors Cancer caused change checked Consensus COVID-19 COVID-19 pandemic death decrease Diagnosis dissemination Ethics finding FIVE growth Guidance human participant Impact IMPROVE inclusion criteria independent item limit Neoplasms Patient patients with COVID-19 peer-reviewed performed ProQuest PROSPERO Prostate Prostate cancer Prostate disease protocol recommendations reported Reporting resolved review risk SARS-CoV-2 screened Screening searched selected significantly systematic review the Newcastle-Ottawa Scale Transmission Tumours Urological tumours. Web of Science [DOI] 10.1136/bmjopen-2022-063748 PMC 바로가기
Bimodal distribution pattern associated with the PCR cycle threshold (Ct) and implications in COVID-19 infectionsPCR 주기 역치(Ct)와 관련된 바이모달 분포 패턴 및 COVID-19 감염에 미치는 영향Article Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술, [키워드] 2019-nCoV age bimodal bimodal distribution cell types Chain Reaction Characteristics clinical sample clinical samples Combination Control COVID-19 COVID-19 infection COVID-19 pandemic Ct values cycle threshold disease control Disease progression dissemination distribution DNA epithelial cells examined explain Gender Genome heterogeneity host response implication Infection infection control Integrated DNA Technologies mucosal notable PCR PCR cycle platform polymerase chain reaction positive prevention ranged real-time RT-PCR respiratory respiratory epithelial cells RT-PCR sample collection SARS-CoV-2 stratified TaqPath ThermoFisher Scientific threshold Transmissibility Transmission Viral Viral load viral replication viral variant Viral variants [DOI] 10.1038/s41598-022-18735-2 PMC 바로가기 [Article Type] Article
Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19SARS-CoV-2의 초기 분리물은 COVID-19의 형질도입된 마우스 모델에서 다른 병인을 초래합니다Article Published on 2022-08-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adenovirus alveolar inflammation BALB/c mice body weight Body weight loss Clinical sign Clinical signs COVID-19 dissemination expression followed by hACE2 hACE2 receptor Histopathology in vivo Infection isolate isolates kidney liver lung Lung histopathology Lungs mice Model mouse mouse model peaking post infection provide response Result resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus variant spleen subsequent recovery susceptible the SARS-CoV-2 virus transduced transduction undetectable Victoria viral variant Viral variants virulence virus weight loss [DOI] 10.3390/v14081769 PMC 바로가기 [Article Type] Article