High‐throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae고처리량 CRISPRi 표현형 분석이 폐렴구균에서 새로운 필수 유전자를 식별합니다.Article Published on 2017-05-102024-08-01 Journal: Molecular Systems Biology [Category] 폐렴구균 감염증, [키워드] bacterial cell wall Chromatin, Epigenetics, Genomics & Functional Genomics competence DNA replication Gene essentiality Genome-Scale & Integrative Biology Microbiology, Virology & Host Pathogen Interaction teichoic acid biosynthesis [DOI] 10.15252/msb.20167449 PMC 바로가기 [Article Type] Article
Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends텔로미어의 Ku 결합은 물리적 염색체 말단에서 먼 부위에서 발생Research Article Published on 2016-12-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] association bind binding Cancer caused cells chromatin chromosome chromosomes complex difficulty DNA DNA binding DNA break DNA breaks DNA replication double-stranded elements elongation End facilitate finding followed by function generate Genome hallmark independent induce interstitial lead mechanism NHEJ non-homologous occur physical predict Previous studies protein-protein interaction proximal reduce Region repair Replication replication fork reported Site solution telomerase telomere telomeres transition turn yeast [DOI] 10.1371/journal.pgen.1006479 PMC 바로가기 [Article Type] Research Article
Hard-Wired Control of Bacterial Processes by Chromosomal Gene Locationarticle Published on 2016-10-312024-09-01 Journal: Trends in Microbiology [Category] 폐렴구균 감염증, [키워드] Bacillus subtilis cell fate determination chromosome organization DNA replication gene dosage Streptococcus pneumoniae stress response Vibrio cholerae [Article Type] article
Varicella-zoster virus (VZV) origin of DNA replication oriS influences origin-dependent DNA replication and flanking gene transcriptionArticle Published on 2015-07-012023-05-31 Journal: Virology [Category] 두창, 수두, 홍역, [키워드] DNA replication Flanking gene transcription OriS VZV. [DOI] 10.1016/j.virol.2015.02.049 PMC 바로가기
The Three Faces of Riboviral Spontaneous Mutation: Spectrum, Mode of Genome Replication, and Mutation Rate리보바이러스 자연 돌연변이의 세 가지 측면: 스펙트럼, 게놈 복제 모드 및 돌연변이 비율Research Article Published on 2012-07-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ameliorated Analysis animals antiviral drugs Author average bacteriophage bacteriophages base substitution base substitutions characterization concerning detected disease Diseases DNA replication Escherichia coli exceptional face Frequency gene encoding generate genome replication growth Host hypermutation in vivo indels infecting Infection information investigated isolates iterative linear linear mode magnitude mammalian mode Mutagenesis mutant Mutation mutation rate mutational spectrum mutations pathogen Pathogens phage plants Plasmid Population produced Protein public health Rate reduce relative frequencies relative frequency Replication reported reporter resistance mutations RNA Sequencing analysis Signaling Spectrum Spontaneous spontaneous mutation subject these viruses trans transversion urgency viral disease virus viruses was used [DOI] 10.1371/journal.pgen.1002832 PMC 바로가기 [Article Type] Research Article
SARS coronavirus protein 7a interacts with human Ap 4 A-hydrolaseResearch Published on 2010-02-092022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activated Activation Amino acid Apoptosis cell proliferation cellular co-immunoprecipitation culture cell cytoplasm DNA repair DNA replication ENCODE expressing Frame Host Human human cell interact Interaction involved nucleotide ORF pathogenic processe Protein protein synthesis Proteins Regulation responsible RNA SARS Coronavirus SARS-CoV sequence homology shown tissue virus yeast [DOI] 10.1186/1743-422X-7-31 PMC 바로가기 [Article Type] Research