Evaluation of Host Protein Biomarkers by ELISA From Whole Lysed Peripheral Blood for Development of Diagnostic Tests for Active Tuberculosis활동성 결핵 진단 테스트 개발을 위한 전 용해 말초 혈액에서 ELISA에 의한 숙주 단백질 바이오마커 평가Article Published on 2022-05-202022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] analyses assay associative barrier Biomarker Biomarkers blood sample CALCOCO2 capture cause of death caused CD274 CD52 collected combinations complex conducted confirmatory tests consequence Control correlation country COVID-19 pandemic death defined development diagnosing Diagnosis diagnostic diagnostic test differentially expressed disease Diversity downregulated ELISA ENhance eradication evaluate expression GBP1 group groups Health Health crisis IFIT3 IFITM3 improvement Improvements incidence India individuals infected individuals Infection Infectious disease information investigated Key priorities key priority Laboratory Lateral flow device lysed negative controls nine Patient peripheral profile Protein protein expression Protein target protein targets qPCR Rapid reducing required ROC SAMD9L significantly SNX10 Stratification Test the WHO Tuberculosis validation study WHO World Health Organisation [DOI] 10.3389/fimmu.2022.854327 PMC 바로가기 [Article Type] Article
Identification of Diagnostic Gene Markers and Immune Infiltration in Systemic Lupus전신성 루푸스에서 진단 유전자 마커 및 면역 침윤의 식별Article Published on 2022-05-102022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 바이오마커, 치료기술, [키워드] Activation advancement Analysis analyzed Atypical autoantibodies autoantibody Autoantigens Autoimmune disease B cells bioinformatics Biomarker Central nervous system characteristic clinical manifestation clinical manifestations Clinical practice coexpressed coexpression network complexes control group coronavirus coronavirus disease correlation COVID-19 current DEGs determine Diagnosis diagnostic differentially expressed gene Differentially expressed genes disease downloaded downregulated Endocrine endocrine system enrichment analysis etiology evaluate expression data Factors fraction functional gene expression profile Genes Genetic GEO database healthy control healthy controls help heterogeneous highest hub genes human body identification identify Immune cell immune cells Immune complexes immune function Infection Interaction joints KEGG kidney leukemia Lupus lupus erythematosus miRNA multiple organs Participation Pathogenesis pathway Pathways Patient patients performed Population Potential biomarker potential biomarkers PPI PPI network protein-protein interaction receiver operating characteristic recognize regulatory network Research resulting ribosome ROC ROC Curve RPL19 RPS17 RPS19 RPS7 selected skin SLE SLE patient SLE patients Symptom systemic systemic lupus erythematosus T cell T cells the disease the healthy transcription factor Treatment turquoise module upregulated variety virus was selected was used weighted gene coexpression network analysis WGCNA whole blood sample [DOI] 10.1155/2022/3386999 PMC 바로가기 [Article Type] Article
Altered hypoxia inducible factor regulation in hereditary haemorrhagic telangiectasia Research Published on 2022-04-072022-10-05 Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] affecting Altered analysed BMP Brain characterized clinical phenotype consequence contribute decreased expression downregulated downregulation dysregulation Effect expression Factor Gene Expression growth HIF-1α HIF1a human disease hypoxia immune response indicate Inflammatory Inflammatory response interact Interaction liver lung malformation mechanism mRNA Mutation no correlation not affected pathway Patient patients protein level rare disease Regulation severity Shunt significantly Structure structures syndrome target gene telangiectasia TGF-β upstream vessel whole blood sample [DOI] 10.1038/s41598-022-09759-9 [Article Type] Research
Morphological and Immunopathological Aspects of Lingual Tissues in COVID-19COVID-19에서 혀 조직의 형태학적 및 면역병리학적 측면Article Published on 2022-04-062022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] ACE2 alteration aspect association cadaver caused circumvallate papillae COVID-19 destruction detect detectable died disease disorder downregulated evidenced factor VIII filiform histological analysis histology IFN-γ immunopathological Inflammation Inflammatory lingual lingual papillae loss of taste manifestation molecular analysis Morphological no difference no differences oral manifestations Patient positive processed provided real-time RT-PCR RT-PCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe inflammation severity Signs and symptoms subject Symptom Symptoms Taste taste buds the disease tissue tongue tongue. two groups variety virus [DOI] 10.3390/cells11071248 PMC 바로가기 [Article Type] Article
New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts Research Published on 2022-03-112022-10-05 Journal: Cell Death Discovery [Category] 진단, 치료기술, 치료법, [키워드] ACE2 AKT cannabis caused Cell Combination components COVID-19 COX2 downregulated Epigenetic expression Extract Factor Features fibroblast highlighting IL-6 IL-8 inflammatory mediator inhibited Interaction lung mechanism miRNA modulated New pathway proinflammatory suppressed target cell the SARS-CoV-2 virus TMPRSS2 TMPRSS2 expression [DOI] 10.1038/s41420-022-00876-y [Article Type] Research
Potential “Therapeutic” Effects of Tocotrienol-Rich Fraction (TRF) and Carotene “Against” Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling PathwaysArticle Published on 2022-03-052022-10-31 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] administration alteration Anti-inflammatory antioxidant Apoptosis approach Bacterial biochemical BLM candidate carotene caused collagen Combination demonstrated develop disease downregulated downregulation drug Effect expressions Factors fibrosis fraction functions genetics histopathological histopathological finding hydroxyproline increased expression Inflammatory cytokine influences inhibit injection interstitial investigated Lung fibrosis Lung injury lung tissues management modulation molecular NF-κB NF-κB signaling Pathways post-COVID-19 patient Potential preventive effects Probability proinflammatory cytokines provided pulmonary pulmonary fibrosis rapid progress RAT reduction in reported shown significantly tocotrienol-rich fraction treated Treatment TRF upregulation variety viral infections [DOI] 10.3390/nu14051094 PMC 바로가기 [Article Type] Article
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates비인간 영장류에서 SARS-CoV-2 변이체에 대한 재조합 단백질 소단위 백신 및 불활성화 백신의 면역원성 및 보호 효능Article Published on 2022-03-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Alpha antibody Antibody titers antibody-dependent cellular cytotoxicity B.1.351 Beta Beta variant binding Breakthrough infection circulating variant COVID-19 vaccine cytokine declined Delta demonstrated domain downregulated effective Efficacy followed by immune memory immunized immunogenicity inactivated Inactivated vaccine increase in Infection Inflammatory cytokine involved lung tissue lung tissues Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer non-human primate omicron Omicron variants Other pathological changes post vaccination Protective protective effect protective mechanism Protein subunit protein subunit vaccine prototype provided RBD Receptor-binding domain reduction respiratory respiratory tracts rhesus macaque rhesus macaques SARS-CoV-2 variant sera significantly Strains Vaccine Vaccines variant Viral Viral load virus VOCs was reduced [DOI] 10.1038/s41392-022-00926-y PMC 바로가기 [Article Type] Article
The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expressionOM-85 박테리아 용해물은 SARS-CoV-2 수용체 발현을 하향 조절하여 상피 세포의 SARS-CoV-2 감염을 억제합니다Article Published on 2022-03-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 비임상, 유전자 메커니즘, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration airway airway epithelial cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacteria Bacterial bacterial lysate binding bronchial epithelial cells caused Cell cell entry cell interactions cell lines coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 downregulated downregulating downregulation Effect enzyme epithelial epithelial cell epithelial cell line epithelial cells expression HEK293T cell host cells human airway human epithelial cell human epithelial cells immunomodulating in vitro infect Infection inhibit inhibited Interaction intestinal kidney lentiviral particles lentivirus lung mRNA Multiple OM-85 organ organs Prevent primary bronchial epithelial cells primary human bronchial epithelial cells protease PROTECT Protein Protein binding protein expression pseudotyped lentiviral particles reduce respiratory infections S protein S1 protein safety profile SARS-CoV-2 SARS-CoV-2 cell infection SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 S1 protein Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly TMPRSS2 Transcription transmembrane transmembrane protease serine 2 treated Treatment were measured [DOI] 10.1016/j.jaci.2021.11.019 PMC 바로가기 [Article Type] Article
Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality순환하는 miR-320b 및 miR-483-5p 수준은 COVID-19 병원 내 사망률과 관련이 있습니다Comparative Study Published on 2022-03-012022-09-11 Journal: Mechanisms of ageing and development [Category] MERS, 바이오마커, 진단, [키워드] adjusted Analysis analyzed Biomarker circulating circulating miRNA circulating miRNAs Cohort confounders COVID-19 COVID-19 patient Cox regression models Deceased deregulated downregulated expression levels highest Hospital mortality IMPROVE In-hospital in-hospital mortality increased risk independent invasive Kaplan-Meier management microRNA MiR-320b MiR-483-5p miRNA miRNAs molecular mortality risk Older older patients Patient Patient management Physicians qRT-PCR risk of COVID-19 RNA-Seq selected Serum level serum levels serum sample serum samples significantly Stratification survived Survivors upregulated validation cohort with COVID-19 [DOI] 10.1016/j.mad.2022.111636 PMC 바로가기 [Article Type] Comparative Study
Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid RaftsImmunology Published on 2022-02-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 affected Calu-3 cell caused cell entry cell membrane Clinical studies coronavirus 2 Coronavirus disease 2019 Course COVID-19 dependent on Disruption downregulated exhibit experimental evidence hospitalized patient human neutrophils in vitro in vivo Infection Inflammation inflammatory cytokine production Inflammatory response inhibiting Lipid Lipid rafts lung damage lung epithelial mechanism mice modulate Monocytes Mortality Peripheral blood protective effect raft reduced reported respiratory response SARS-CoV-2 SARS-COV-2 infection significantly Simvastatin statin systemically tissue Treatment triggered viral replication virus with COVID-19 [DOI] 10.3389/fimmu.2022.820131 PMC 바로가기 [Article Type] Immunology