Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approachResearch article Published on 2020-11-012022-10-05 Journal: Toxicology and applied pharmacology [Category] SARS, 치료법, [키워드] affected Anti-COVID-19 Therapy antibiotic antiretroviral drugs apoA1 approach Autoimmune diseases Azithromycin BCL2L1 benefit candidate drug CCL2 Chloroquine chloroquine/hydroxychloroquine clinical condition Combination Comparative COVID-19 CTSB CXCL8 CYP3A4 Cytoscape software demonstrated Diseases disorders downregulated drug drug combination dyslipidaemia expected expression greater ICAM1 IL1B IL6 immune response improvement in silico in silico Approach infected patient Inflammation involved lipid metabolism Lopinavir Patient pharmacological problems Research risk Ritonavir Safety SARS-CoV-2 therapy TNF Toxicogenomics Treatment was used [DOI] 10.1016/j.taap.2020.115237 [Article Type] Research article
Statin use is associated with lower disease severity in COVID-19 infectionArticle Published on 2020-10-152022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 임상, 치료기술, 치료법, [키워드] adjusted Admission age analysed association clinical Clinical outcome COVID-19 infection COVID-19 patients death disease severity dyslipidaemia Endocrine system and metabolic diseases Gender hyperlipidemia ICU ICU admission invasive Logistic medication outcome outcomes oxygen Patient Regression model requiring supplemental oxygen retrospective cohort risk Risk factors severity significant difference Singapore statin statistical significance statistical test Support Treatment two-sided was determined were used with COVID-19 [DOI] 10.1038/s41598-020-74492-0 PMC 바로가기 [Article Type] Article
Vascular Events, Vascular Disease and Vascular Risk Factors—Strongly Intertwined with COVID-19Reflections from the Covid Pandemic (A Iranzo and M Rosenfeld, Section Editors) Published on 2020-10-082022-10-31 Journal: Current Treatment Options in Neurology [Category] COVID-19, [키워드] age alcohol Arterial hypertension clinical benefit COVID-19 COVID-19 pandemic COVID-19 patients death demonstrated Diabetes Mellitus disease driver dyslipidaemia events Evidence Healthcare professional include increased risk Infection Inflammation Interaction ischaemic stroke multifactorial outcome Pathologies Patient Perspective Physical inactivity populations prevention rate of infection recent reduce risk risk factor Risk factors severe COVID-19 shown smoking stroke Vascular vascular disease vascular events Vascular risk factors with COVID-19 [DOI] 10.1007/s11940-020-00648-y PMC 바로가기 [Article Type] Reflections from the Covid Pandemic (A Iranzo and M Rosenfeld, Section Editors)
Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II)Original Investigation Published on 2020-10-012022-10-31 Journal: Cardiovascular Diabetology [Category] COVID-19, MERS, SARS, [키워드] 95%CI Admission adverse outcomes cardiometabolic cardiometabolic condition cardiometabolic conditions Cardiometabolic risk cardiometabolic risk factor Characteristics chronic obstructive Cluster collected confounders COPD COVID-19 death defined diabete diabetes disorder dyslipidaemia enrolled feature Features higher risk Hospitalized hypertension increased risk Inflammatory marker intensive care investigated Logistic regression mechanical ventilation multicentre Multimorbidity multivariate not differ Older age outcome outcomes Patient patients hospitalized patients with diabete Prevalence Prognosis pulmonary disease Ratio Result Retrospective study risk risk factor SARS-CoV-2 was used [DOI] 10.1186/s12933-020-01140-2 PMC 바로가기 [Article Type] Original Investigation
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective studyResearch Published on 2020-08-142022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] ACE2 adaptive age analysed angiotensin-converting enzyme inhibitor Asia average blocker C-reactive protein carried CD19 CD4 CD8 Clinical course cohorts Comorbidities country Course COVID-19 COVID-19 pandemic COVID-19 severity decrease Deleterious diabetes disease dyslipidaemia effectors enzyme European evidenced Fatality rate feature form health authorities hospitalized patient hypertension hypertensive patient immune system Immunity immunological immunosenescence inhibitor innate response interleukin 6 interleukin-6 Laboratory Local lymphocyte Lymphocyte count Lymphocytes male males Mild moderate multicentre natural killer Older outcome Patient Prognosis protective effect public health ranged receptor renin-angiotensin system reported Result Retrospective study risk factor SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severity significantly lower Spain Spanish spread to subpopulation the disease was performed [DOI] 10.1186/s12979-020-00194-w PMC 바로가기 [Article Type] Research
Cholesterol-modifying drugs in COVID-19Short Communication Published on 2020-06-182022-10-29 Journal: Oxford Open Immunology [Category] COVID-19, [키워드] Alter anti-inflammatory effect Antiviral cardiovascular disease cholesterol cholesterol-modifying drugs coronavirus COVID-19 drug dyslipidaemia dyslipidemia Effect highlight Immune cell Immunity immunomodulatory in vitro in vivo models Inflammation management mechanism membranes obesity outcome pleiotropic promote protective immunity Replication resulting SARS-CoV-2 SARS-COV-2 infection statin statins syndrome systemic inflammatory responses T-cells tested the SARS-CoV-2 viral immunology virus virus infectivity [DOI] 10.1093/oxfimm/iqaa001 PMC 바로가기 [Article Type] Short Communication
Chronic hepatitis B virus infection and risk of dyslipidaemia: A cohort studyArticle Published on 2019-01-012023-06-18 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] cohort study dyslipidaemia Hepatitis B virus incidence risk [DOI] 10.1111/jvh.13014
The non-immunosuppressive management of childhood nephrotic syndromeReview Published on 2015-11-102024-09-02 Journal: Pediatric Nephrology (Berlin, Germany) [Category] 대상포진, [키워드] dyslipidaemia idiopathic nephrotic syndrome Infection oedema thrombosis vaccination [DOI] 10.1007/s00467-015-3241-0 PMC 바로가기 [Article Type] Review
Elevated blood lipids are uncommon in patients with post-polio syndrome – a cross sectional study폴리오 후 증후군 환자에서 혈중 지질 상승은 드물다 – 단면 연구Research Article Published on 2015-04-292024-07-28 Journal: BMC Neurology [Category] 폴리오, [키워드] cardiovascular risk dyslipidaemia neuromuscular disease Post-polio syndrome [DOI] 10.1186/s12883-015-0319-z PMC 바로가기 [Article Type] Research Article