Antivirals for adult patients hospitalized with SARS-CoV-2 infection: A randomized, Phase II/III, multicenter, placebo-controlled, adaptive study, with multiple arms and stages. COALITION COVID-19 BRAZIL IX – REVOLUTIOn: protocol and statistical analysis planSARS-CoV-2 감염으로 입원한 성인 환자를 위한 항바이러스제: 다중 병기와 단계를 포함하는 무작위, II/III상, 다기관, 위약 대조, 적응 연구. COALITION COVID-19 BRAZIL IX - 혁명: 프로토콜 및 통계 분석 계획Article Published on 2022-01-012022-09-11 Journal: Revista Brasileira de Terapia Intensiva [Category] SARS, 임상, 치료제, [키워드] adaptive antiviral drugs Arm Atazanavir Combination COVID-19 daclatasvir decrease described drug effective emerging disease English Evidence expected Hepatitis hepatitis C hepatitis C virus HIV Hospitalized identify initiated Intervention maintain medication multicenter Neste oxygen pacientes com COVID-19 para participant Participants Patient patients hospitalized patients with COVID-19 pelo phase Placebo placebo-controlled Population protocol randomizado Randomized rationale reduce Repurposed drugs Respiratory Support revolution room air SARS-CoV-2 sofosbuvir SpO2 Stage stages Statistical analysis plan status supplemental oxygen Symptom tested the SARS-CoV-2 total sample size Trial Viral load [DOI] 10.5935/0103-507X.20220002-pt PMC 바로가기 [Article Type] Article
Comparison of Experimental Middle East Respiratory Syndrome Coronavirus Infection Acquired by Three Individual Routes of Infection in the Common MarmosetPathogenesis and Immunity Published on 2021-12-152022-10-30 Journal: Journal of Virology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Callithrix jacchus Acquired acute respiratory syndrome aerosol route Aerosols animal animal model breathing difficulties Callithrix caused challenge characterized common complications Concentration coronavirus cough demonstrated described disease emerging disease England Erasmus Fatality rate Fever Host host response Human Immunological response individual interstitial pneumonia intranasal Lung disease lung tissue Macrophage macrophages marmoset medical countermeasure MERS-CoV Middle East Middle East respiratory syndrome Mild neutrophil function Neutrophils Pneumonia Pyrexia renal respiratory respiratory syndrome coronavirus route SARS-CoV-2 severity Shortness of breath strain syndrome the disease throat swab upregulation Viable virus were used [DOI] 10.1128/jvi.01739-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows Research Published on 2021-12-142022-10-05 Journal: Nature Microbiology [Category] SARS, 유전자 메커니즘, [키워드] approach Cluster Contamination detect diagnostic DNA Efficiency emerging disease epidemiological Evolution of SARS-CoV-2 Genome genomic genomic data hospital in viral Interpretation Laboratory multiple laboratories Outbreaks provide SARS-CoV-2 SARS-CoV-2 sequencing sequence Sequencing sequencing method Spread Surveillance synthetic utility variety [DOI] 10.1038/s41564-021-01019-2 [Article Type] Research
Exploring COVID-19 patients’ experiences of psychological distress during the disease course: a qualitative studyResearch Published on 2021-12-112022-10-27 Journal: BMC Psychiatry [Category] COVID-19, [키워드] acute phase Analysis analyzed Anxiety boost Care category caused conducted counseling Course COVID-19 Data analysis death dimensions disease severity distress emerging disease explain Health health instruction health system help inefficient Infection Infectious disease Iran lack Local management Measures media mental condition not applicable participant Patient patients patients with COVID-19 provided Psychological Psychological distress psychological problem Qualitative qualitative study quarantine Research Result selected Seven spiritual care suggested Support the disease therapeutic thought Treatment understanding variety was collected with COVID-19 [DOI] 10.1186/s12888-021-03626-z PMC 바로가기 [Article Type] Research
Exploring COVID-19 patients’ experiences of psychological distress during the disease course: a qualitative studyResearch Published on 2021-12-112022-10-27 Journal: BMC Psychiatry [Category] Coronavirus, COVID-19, SARS, [키워드] acute phase Analysis analyzed Anxiety boost Care category caused conducted counseling Course COVID-19 Data analysis death dimensions disease severity distress emerging disease explain Health health instruction health system help inefficient Infection Infectious disease Iran lack Local management Measures media mental condition not applicable participant Patient patients patients with COVID-19 provided Psychological Psychological distress psychological problem Qualitative qualitative study quarantine Research Result selected Seven spiritual care suggested Support the disease therapeutic thought Treatment understanding variety was collected with COVID-19 [DOI] 10.1186/s12888-021-03626-z PMC 바로가기 [Article Type] Research
dockECR: Open consensus docking and ranking protocol for virtual screening of small moleculesdockECR: 소분자의 가상 스크리닝을 위한 개방형 합의 도킹 및 순위 지정 프로토콜Article Published on 2021-12-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] SARS, 치료기술, 치료제, [키워드] accelerate addition applied approaches AutoDock AutoDock vina average Candidates co-crystallized complement Consensus crystal structure docking eight emerging disease evaluated Exponential consensus ranking Frame information Interaction library molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations molecules Open source predicted protease Protein Protein target protocol ranking residue RMSD SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 virus small molecule targets the SARS-CoV-2 virus Treatment Virtual screening was used were used [DOI] 10.1016/j.jmgm.2021.108023 PMC 바로가기 [Article Type] Article
Identification and Development of Therapeutics for COVID-19Review Published on 2021-11-022022-10-29 Journal: mSystems [Category] COVID-19, [키워드] acute respiratory syndrome approach building candidate Characteristics China coronavirus coronavirus disease COVID-19 COVID-19 crisis COVID-19 pandemic data-driven development disease drug Effect emerging disease Epidemics FDA food host response humans identification identify infect Infection information Intervention management Middle East Novel coronavirus novel coronavirus disease offer pandemic Pathologies pharmacological physical provide public health measures regulatory agency Research review SARS-CoV-2 Scientific community severity shifting Spread syndrome the SARS-CoV-2 virus Therapeutics threat Treatment viral epidemics Virological virus [DOI] 10.1128/mSystems.00233-21 PMC 바로가기 [Article Type] Review
The Outcome of COVID-19 in Patients with a History of Taking Rituximab: A Narrative Review리툭시맙 복용 이력이 있는 환자의 COVID-19 결과: 내러티브 검토Review Published on 2021-11-012022-09-12 Journal: Iranian journal of medical sciences [Category] 진단, [키워드] addressed appear Autoimmune disease caused CD20 Clinical course Concomitant medication coronavirus 2 Coronavirus disease 2019 Course COVID-19 Diseases Efficacy emerging disease history immune system diseases Immunosuppressive medication increased risk indicated Infection infections Infectious disease malignancies monoclonal antibody morbidity and mortality narrative pandemic Patient patients patients with SARS-CoV-2 previous study receiving respiratory review rituximab RTX SARS-CoV-2 Taking the disease Treatment underlying disease Vaccine [DOI] 10.30476/IJMS.2021.88717.1946 PMC 바로가기 [Article Type] Review
Gut microbiota of bats: pro-mutagenic properties and possible frontiers in preventing emerging diseaseArticle Published on 2021-10-262022-10-29 Journal: Scientific Reports [Category] Coronavirus, Fulltext, MERS, SARS, 조류인플루엔자, [키워드] Animal physiology antioxidant Antiviral antiviral response Bacteria Bacterial physiology bat bats Cell COVID-19 DNA DNA damage double-strand break Ebola emerging disease expression gut bacteria gut microbiota Host human diseases hydroxyl radical immune indicated infections Inflammatory response involved lactic acid mechanism MERS Microbiology microbiota mutagenic oxidative performed reservoir reveal Tolerance virus viruses was determined [DOI] 10.1038/s41598-021-00604-z PMC 바로가기 [Article Type] Article
Proactive Engagement of the Expert Meeting in Managing the Early Phase of the COVID-19 Epidemic, Japan, February–June 2020Online Report Published on 2021-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] communicable diseases coronavirus disease COVID-19 defined effective emerging disease Engagement expert Government health communication Intervention Japan leadership management managing meeting pandemic Pandemics phase policy making public health practice reflected respiratory infections response risk Risk assessment SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses zoonoses [DOI] 10.3201/eid2710.204685 PMC 바로가기 [Article Type] Online Report