Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences인도-아프리카 서열을 기반으로 하는 EDIII-NS1 컨센서스 디자인을 암호화하는 새로운 뎅기열 DNA 백신의 면역 프로필 및 반응Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, 변종, 진단, [키워드] antibody Antibody-dependent enhancement Antigen antigens clinical isolates coding sequence Consensus consensus sequence conserved COVID-19 pandemic Dengue dengue surveillance. dengue virus DENV-2 DNA DNA vaccine domain domain III EDIII domain emerging viruses envelope protein epitope Epitopes expand Genotype highlight IgG1 immune immune response immunogenic Immunoglobulin India Indo-African interferon isolate mice neutralizing antibody non-structural protein NS1 protein passive transfer protein expression response sequence Sequencing sera serotype serotype-specific staining Stand Structural analysis Surveillance T cell T cell responses transfer translation vaccination Vaccine vaccine candidate Vaccine design Viral Viral variants virulent viruses whole genome Whole genome sequencing [DOI] 10.1016/j.ymthe.2022.01.013 PMC 바로가기 [Article Type] Article
Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2Article Published on 2022-04-152023-07-02 Journal: Viruses [Category] COVID19(2023년), SARS, [키워드] antiviral action Antiviral mechanism docking simulation emerging viruses lamellarin α 20-sulfate marine alkaloid Molecular dynamics simulation Pseudotyped lentiviral vector [DOI] 10.3390/v14040816 PMC 바로가기 [Article Type] Article
What Should Be Learned From Repurposed Antivirals Against SARS-CoV-2?Microbiology Published on 2022-02-162022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Against Antiviral emerging viruses Repurposed drugs SARS-CoV-2 virus therapy [DOI] 10.3389/fmicb.2022.843587 PMC 바로가기 [Article Type] Microbiology
RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infectionResearch article Published on 2022-02-132022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] Activation agonist Antiviral antiviral immunity antiviral response Antiviral treatment approach Brain coronavirus COVID-19 disease severity effective emerging viruses exhibited innate antiviral immunity innate immune Innate immunity K18-hACE2 K18-hACE2 mouse model Ligand lung Lung inflammation mice MT: Oligonucleotides: Therapies and Applications Neutralizing antibody response nucleic acid immunity oropharyngeal swab outcome pandemic Prophylactic PROTECT receptor reduce reduced RIG-I RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Spread survival therapeutic therapy Treatment Type I IFN type I interferon Vaccine viral challenge Viral load virus viruses [DOI] 10.1016/j.omtn.2022.02.008 [Article Type] Research article
The Myotis chiloensis Guano Virome: Viral Nucleic Acid Enrichments for High-Resolution Virome Elucidation and Full Alphacoronavirus Genome AssemblyArticle Published on 2022-01-202022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] acid alphacoronavirus assembly bat characterized Chilean Community complicate coronavirus ecological ecosystem emerging viruses ENhance enrichment epidemiological favor Guano high mortality rate High-resolution highlight Human identify include knowledge mammal Myotis PEDV persistence Population secure severe disease Spread Surveillance turn unique variety viral pathogen viral reads virome virome and bats viruses widespread zoonosis zoonotic zoonotic pathogens [DOI] 10.3390/v14020202 PMC 바로가기 [Article Type] Article
The emergence of new SARS-CoV-2 variant (Omicron) and increasing calls for COVID-19 vaccine boosters-The debate continues새로운 SARS-CoV-2 변종(Omicron)의 출현과 COVID-19 백신 부스터에 대한 요구 증가-토론은 계속됩니다Article Published on 2022-01-012022-09-11 Journal: Travel medicine and infectious disease [Category] SARS, 변종, [키워드] Abstract booster dose COVID-19 vaccine emerging viruses new SARS-CoV-2 omicron SARS-CoV-2 variant variant of concern [DOI] 10.1016/j.tmaid.2021.102246 PMC 바로가기 [Article Type] Article
Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral TherapiesArticle Published on 2021-12-142022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Analysis antimetabolite Antiviral antiviral therapy blunting broad-spectrum cellular clearance clinical trial Combination competing coronavirus Defense Ebola virus effective emerging viruses Enhancing Favipiravir forms Frequency HCoV-OC43 Illness severity infections influenza A inhibitor Mutation NTP nucleobase nucleosides nucleotide orthomyxovirus Patient potency Potential purine reduced reducing reduction Replication riboside RNA virus SARS-CoV-2 small molecule Spread synergistic synergy Treatment Vaccine virus Zika [DOI] 10.3390/v13122508 PMC 바로가기 [Article Type] Article
Estimating epidemiologic dynamics from cross-sectional viral load distributions단면 바이러스 부하 분포에서 역학적 역학 추정Article Published on 2021-09-262022-09-12 Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect approach arising biases calibrated can be used Care Chain Reaction changes in collected conducted coronavirus Course cross cross-sectional Ct values current cycle threshold death declining develop Diseases distribution emerging viruses Epidemic estimate feature flexible framework growth growth rate highlight Hospital admission hospitalizations implication IMPROVE incidence individual individuals infected individual Infection infection prevalence Infectious diseases information inherent Intervention Long-term care management Massachusett Massachusetts mathematical mathematical model Metrics offer Older outbreak overcome pandemic performed polymerase chain polymerase chain reaction population distribution populations positive Precision proportion proportions provide Public health response Public health responses Quantitative random Random sample rationale real time reflect reflected repeated reported Reporting reproductive reveal reverse transcription reverse transcription quantitative polymerase chain reaction rising robust robustness RT-qPCR sample collection SARS-CoV-2 SARS-CoV-2 testing severe acute respiratory syndrome Coronavirus specimen Surveillance surveillance data surveillance testing the epidemic the median trajectory turn understanding variant variants Variation variety viral kinetics Viral load viral loads virus [DOI] 10.1126/science.abh0635 PMC 바로가기 [Article Type] Article
Single-Particle Characterization of SARS-CoV-2 Isoelectric Point and Comparison to Variants of InterestCommunication Published on 2021-07-282022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] adhesion Adsorption aligning Amino acid amino acid sequence approach biochemical Biophysics characterization coronavirus COVID-19 demonstrated dipole distal emerging viruses encoded proteins estimate Evidence functional Genetic global pandemic highly pathogenic highly pathogenic specy homology hydrophobicity interest nucleic acid Organisms Point Prevent proliferation Protein recent SARS-CoV-2 sequence surface characterization variants of interest Viral protein Viral RNA Viral transmission virus viruses VOIs [DOI] 10.3390/microorganisms9081606 PMC 바로가기 [Article Type] Communication
Drug repurposing for COVID-19: Approaches, challenges and promising candidatesReview Published on 2021-06-232023-06-15 Journal: Pharmacology & therapeutics [Category] MERS, [키워드] antivirals clinical trials COVID-19 Drug repurposing emerging viruses [DOI] 10.1016/j.pharmthera.2021.107930 PMC 바로가기 [Article Type] Review