Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?Physiology Published on 2021-10-042022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] addition Adverse adverse effect Apoptosis Apoptotic cell death Cancer cancers cardiovascular diseases Cell cell death Characteristics common Control COVID-19 death Diabetes Mellitus Diabetic diabetic patients disease Diseases drug candidate Effect energy metabolism gut microbiota Hexokinase include Inflammation inhibiting Kidney disease metabolism metformin Mitochondria mitochondrial dysfunction neurodegenerative obesity opposite other disease question renal shown VDAC VDAC1 [DOI] 10.3389/fphys.2021.730048 PMC 바로가기 [Article Type] Physiology
The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results분자 기전에서 임상 결과까지 심혈관계에 대한 레스베라트롤의 효과Review Published on 2021-09-212022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] addition Anti-inflammatory anti-inflammatory property antioxidant Antiviral cardiovascular cardiovascular disease cardiovascular diseases cardiovascular system cause Cell clinical COVID-19 death disease Effect energy metabolism favorable effect heart failure human clinical trial Inflammation investigated metabolism oxidative stress pathological condition pathological conditions pathway Perspective Result resveratrol Risk factors Signal transduction System [DOI] 10.3390/ijms221810152 PMC 바로가기 [Article Type] Review
Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and TherapiesSARS-COV-2에 의한 심근 손상 : 신흥 메커니즘 및 요법Review Published on 2021-09-212022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acting action potential acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis arrhythmia ATP attack autophagy cause Cell cells coronavirus creating damage decrease direct infection docking drug early stage early stages Effect effective Endothelial cell endothelial cells energy energy metabolism evade heart host cell Host immune response Imbalance immune cells immune response immunosuppressive immunosuppressive therapy induce infect Inflammation inhibit ion homeostasis lead leads metabolism myocardial damage myocarditis necroptosis organ Potential treatment priming programmed cell death promote protease Protease inhibitor protease inhibitors Proteases pyroptosis receptor Replication respiratory RNA-dependent RNA polymerase ROS production SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus ssRNA stages therapy treatment of viral infection turn Vesicle Viral viral clearance viral docking viral entry viral replication viroporin [DOI] 10.3390/v13091880 PMC 바로가기 [Article Type] Review
Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19Chemistry Published on 2021-09-102022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] activated acute respiratory syndrome adaptive immune system administration alteration antioxidant caused CD4 CD8 Cell change changes in clinical trial complementary Concentration contributing to controlling coronavirus 2 COVID-19 Critically ill patient cytokine disease doses dysregulation energy metabolism epithelial cells Excessive activation form Glucose glycolytic pathway help hyperactivity hyperglycolysis IFN immune system Importance Infection Infectious disease Inflammation inhibitors innate immune innate immune system metabolism non-toxic organism oxidative phosphorylation pathway patients poor prognosis pro-inflammatory cytokine pro-inflammatory cytokines promote reactive oxygen species reduce respiratory epithelial cell SARS-CoV-2 SARS-CoV-2-infected cells secretion suggested syndrome T cells the disease therapeutic strategy thought Treatment underlie understanding viral replication Vitamin C with COVID-19 [DOI] 10.3389/fchem.2021.685196 PMC 바로가기 [Article Type] Chemistry
Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonolsArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] 2019-nCoV 2019-nCoV spike protein adverse effect analyzed binding binding free energy calculated CatB cathepsin cathepsin B cathepsin L CatL cellular Compound COVID-19 Determination effective energy metabolism exhibited FIVE flavonol form glycosidic GOS high mortality in vitro in vivo inhibitory effect Interaction MM/PBSA Modification molecular molecular docking molecular dynamics Novel coronavirus protease rapidly spreading disease RBD Receptor binding domain Research SARS-CoV-2 serine 2 spike glycoprotein stability target targets therapeutic agent these compound These data TMPRSS2 Toxicity transmembrane Treatment was determined while [DOI] 10.3906/biy-2104-51 PMC 바로가기 [Article Type] Article
The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입Immunology Published on 2021-08-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] acetaminophen Activation addition Algorithm Angiogenesis B2M BFS algorithm Bioinformatics analysis biological process biological processe biological processes Brain caused CD40 CD40LG cell-mediated immune cell-mediated immune response changes in Comparative Compound Coronavirus disease 2019 COVID-19 CSF1 Curcumin CXCL10 cytokine Cytokine storm database defined determine Dexamethasone DNA downloaded drug energy metabolism enrichment analysis FCER1G FIVE gene co-expression network Gene Expression gene expression profile Gene expression profiles Gene ontology Genes heterogeneous high mortality hub genes ICAM1 identify immune gene immune response Immunity initial gene IRF7 LAT Lcn2 lead leukocyte lung metabolism molecular mechanism morphology Multiple multiple organ dysfunction multiple organ heterogeneity myeloid leukocyte neuronal Novel coronavirus olfactory organ organs other compound PageRank pandemic pattern PLAU predicted protein metabolism Protein–protein interaction Regulation Research response resveratrol RHOA rRNA second Spread SRC statins Stress stress response targeted intervention the cytokine storm TNFRSF1A TO-GCN Toxicogenomics Trachea tracheal Transmission Treatment unique was performed was used [DOI] 10.3389/fimmu.2021.729776 PMC 바로가기 [Article Type] Immunology
Metabolomics in the Diagnosis and Prognosis of COVID-19Genetics Published on 2021-07-232022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] affected Amino acid Analysis approach clinical setting Compound Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 pandemic COVID-19 patient COVID-19 testing detect Diagnosis diagnostic diagnostics dysregulated effort energy metabolism evaluated Factor Genome greater Host independent Infectious disease Kynurenine pathway mass-spectrometry metabolic pathway metabolism metabolite metabolomics nasopharyngeal swab specimen nuclear magnetic resonance outcome pandemic pathway plasma POC point-of-care profile Prognosis prognostic Prognostic marker Protein Research RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA serum severe disease severity significantly specimens Spread Standardization the disease triggered urgency Viral RNA virus Volatile organic compounds with COVID-19 [DOI] 10.3389/fgene.2021.721556 PMC 바로가기 [Article Type] Genetics
Recent Progress in Metabolic Syndrome Research and TherapeuticsReview Published on 2021-06-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affected approach cellular Characteristics Comprehensive consequence contributed coronavirus differentially expressed disease entity dysregulation energy metabolism facilitate gut microbiota heterogeneity homeostasis Host Impact incidence Infection inflammatory status inquiry mandatory measure mechanism metabolic metabolic parameters metabolic syndrome metabolites metabolomics microbiota molecular pathogenic mechanisms phenotype physical activity Population Precision precision medicine Progress Protein proteomics recent risk SARS-CoV-2 signaling pathway therapeutic Therapeutics Therapies Variation [DOI] 10.3390/ijms22136862 PMC 바로가기 [Article Type] Review
[Energy metabolism characteristic with risk of secondary bacterial infection in patients with hepatitis B virus-related chronic liver disease]Article Published on 2021-06-202023-06-12 Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese [Category] B형 간염, [키워드] energy metabolism Hepatitis B virus Indirect detection Secondary infection [DOI] 10.3760/cma.j.cn501113-20210130-00052
Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?Review Published on 2021-03-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] adaptive immune system adipose approach association blunt Cell chronic complications Concentration concerning contribute Control COVID-19 determinant dysregulation Effect Effectiveness energy balance energy metabolism ER stress expressed Factors immune immune response immune system impair impairment Infection Infectious disease Inflammation inflammatory state Influenza influenza epidemic Interaction Leptin leptin resistance lesson mechanism metabolic microenvironment Multiple obesity outcome overcome pandemic Physical inactivity pleiotropic produced receptor reduced Regulatory Research responsible SARS-CoV2 severity Signaling Surveillance susceptibility tissue Vaccine vaccine-induced immune responses viral infection viral infections [DOI] 10.3390/ijms22063183 PMC 바로가기 [Article Type] Review