Detailed epitope mapping of SARS-CoV-2 nucleoprotein reveals specific immunoresponse in cats and dogs housed with COVID-19 patientsSARS-CoV-2 핵단백질의 상세한 에피토프 매핑은 COVID-19 환자와 함께 수용된 고양이와 개에서 특정 면역 반응을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: Research in veterinary science [Category] MERS, SARS, 진단, 치료법, [키워드] animals Antigen antigenic C-terminus coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID19 develop disease disease control domain Double antigen ELISA ELISA epitope epitope mapping gold gold standard Human immunized Infection initial neutralization test pandemic Patient plaque PRNT Protein raising reported representing respiratory respiratory syndrome coronavirus 2 reveal SARS-CoV-2 SARS-CoV-2 nucleoprotein sera Serological assay specificity susceptible target Transmission Viral Viral antigen was used with COVID-19 [DOI] 10.1016/j.rvsc.2021.12.020 PMC 바로가기 [Article Type] Article
Limited Recognition of Highly Conserved Regions of SARS-CoV-2SARS-CoV-2의 고도로 보존된 지역에 대한 제한된 인식Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antigen-specific CD8+ T cells approach CD8 circulating Community Comparative conservation conserved conserved regions convalescent coronavirus coronavirus disease coronavirus strains COVID-19 Critical cross-protective immunity cross-reactive disease encoded protein epitope epitope mapping Epitopes exposure to FIVE Frame generate immune protection immune response immune responses immunodominant implication individuals less likelihood Limited memory memory T cells nucleocapsid observation Open reading frame ORF1 ORF1ab overcome pandemic Participants polyprotein Preexisting immunity protective role Protein Recognition Region required respiratory robust SARS-CoV-2 SARS-CoV-2 infected cells seasonal coronaviruses Sequence analysis severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease T cell T cell response T cell responses T cells T-cell epitope T-cell epitopes T-cell Response T-cell responses understanding unlikely vaccination volunteers [DOI] 10.1128/spectrum.02780-21 PMC 바로가기 [Article Type] Research Article
Developing an Effective Peptide-Based Vaccine for COVID-19: Preliminary Studies in Mice ModelsCOVID-19에 대한 효과적인 펩티드 기반 백신 개발: 마우스 모델의 예비 연구Article Published on 2022-02-222022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] adjuvant affinity antibody Antibody Response autoimmune responses B cell epitope B cell epitopes B cell response C57BL/6 caused convalescent individuals coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated Developing effective Effectiveness epitope epitope mapping Epitopes flexibility generate Health HLA Human in silico mice Model Neutralizing Neutralizing activity peptide peptide-based vaccine peptides plasma predicted Prevent produced Protein Respiratory Coronavirus Safe SARS-CoV-2 SARS-CoV-2 variant selected Spike protein Spread stimulated T and B cell responses T and B cells T cell T cell responses tested two group two groups Vaccine viral variant Viral variants virus wild-type [DOI] 10.3390/v14030449 PMC 바로가기 [Article Type] Article
Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodiesArticle Published on 2022-02-172023-07-08 Journal: Protein Engineering, Design and Selection [Category] COVID19(2023년), [키워드] antibodies epitope mapping Neutralizing phage display Serological assay serum ELISA. [DOI] 10.1093/protein/gzab033 PMC 바로가기
Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant VirusesArticle Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis anti-viral antibody approach B-cell epitope B.1.1.7 B.1.351 Beta collected contribute COVID-19 COVID-19 vaccine cross-protective diagnostic Efficacy epitope epitope mapping examined Frequency Genetic variant host cell humoral Identified immune immunodominant immunogenic immunological Immunotherapy implication in vitro experiment Infection K18-hACE2 linear epitope linear epitopes mice neutralization tests SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 strain SARS-CoV-2 variants serum sample serum samples spike Spike protein targets the SARS-CoV-2 the spike protein transgenic viral entry virus variant [DOI] 10.3390/vaccines10020251 PMC 바로가기 [Article Type] Article
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cellsSARS-CoV-2에 대한 고친화성 중화 항체는 T 여포 보조 세포 없이 만들 수 있습니다.Article Published on 2022-02-042022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta absence Alternative pathway antibody antibody production Antiviral B cell B cell response B cell responses B.1.351 Cell cell interaction cell interactions cells complement damaged driver effective epitope epitope mapping Epitopes Evidence evidence of follicular Germinal center high affinity homologous Immunoglobulin immunoglobulin class immunoglobulin class switching Infection Inflammation Influenza influenza A influenza A virus influenza A virus infection Neutralizing neutralizing antibody occur operative pathway Patient patients Protective reactive receptor reduced responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination Sequencing severe COVID-19 Support switching T cell These data variant Viral viral infection virus infection [DOI] 10.1126/sciimmunol.abl5652 PMC 바로가기 [Article Type] Article
Machine Learning Techniques for the Prediction of B-Cell and T-Cell Epitopes as Potential Vaccine Targets with a Specific Focus on SARS-CoV-2 Pathogen: A ReviewReview Published on 2022-01-242022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome antibody Antigen antigenic determinant approach B cell B-cell epitopes candidate caused changed composed coronavirus disease Coronavirus-2 costly COVID-19 Critical effective endemics Ensemble model Epidemics epitope epitope mapping epitope-based peptide vaccine Epitopes focus high mutation rate highlighting Human immune system identification identify immune-relevant determinants less machine learning outbreak Pandemics pathogen peptide Potential prediction PROTECT Protein public health reduced required Research review SARS-CoV-2 Specific strain systematic review target technique time-consuming trials vaccination Vaccine variants [DOI] 10.3390/pathogens11020146 PMC 바로가기 [Article Type] Review
Role of anti-HBs in functional cure of HBeAg+ chronic hepatitis B patients infected with HBV genotype AArticle Published on 2022-01-012023-06-13 Journal: Journal of hepatology [Category] B형 간염, [키워드] ADCC ALT antibody B cell response clearance profile epitope mapping Fc receptors FcγRIIIa HBsAg immune complex liver neutralisation [DOI] 10.1016/j.jhep.2021.07.031
Biparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern2중 파라토프 나노바디는 우려되는 SARS-CoV-2 변종으로 인한 치명적인 공격으로부터 마우스를 보호합니다Article Published on 2021-12-202022-09-10 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta active against Analysis B.1 B.1.351 B.1.617.2 Beta cellular circulating circulating variant conserved COVID‐19 Delta Disease progression dose drug candidates effective epitope epitope mapping Epitopes generate high affinity human ACE‐2 mouse human ACE2 immunology in vitro in vivo increased survival Infection Inflammatory response intranasally lethal dose Lungs mice Microbiology, Virology & Host Pathogen Interaction Molecular Biology of Disease nanobodies nanobody neutralize Neutralizing neutralizing nanobodies pandemic Prevent PROTECT RBD receptor‐binding domain reduced SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 significantly Taking Therapeutics These data transgenic mice treat treated variants of concern variety Viral Viral load VoC VOCs [DOI] 10.15252/embr.202153865 PMC 바로가기 [Article Type] Article
Rapid characterization of spike variants via mammalian cell surface displayTechnology Published on 2021-12-162022-10-31 Journal: Molecular Cell [Category] COVID-19, SARS, [키워드] Abstract accelerate ACE2 ACE2 binding Alanine Alpha antibody Antigen antigenicity B.1.1.28 B.1.1.7 B.1.351 B.1.617.2 cell display circulating variant convalescent plasma COVID-19 Critical display ectodomain epitope epitope mapping expression FIVE glycosylated highlight immune system immunogenic mammalian cell Mutagenesis Mutation N-terminal domain neutralizing antibody neutralizing monoclonal antibody NTD peptide platform Proteins Rapid Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike spike variant spike variants Threats Vaccine variant variants variants of concern viral glycoproteins [DOI] 10.1016/j.molcel.2021.11.024 PMC 바로가기 [Article Type] Technology