Ex vivo – Page 3 – Communicable Diseases Research

Natural killer cell homing and trafficking in tissues and tumors: from biology to application

Reviews

Published on 2022-06-292022-10-05
Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커,

Efficacy of Licensed Monoclonal Antibodies and Antiviral Agents against the SARS-CoV-2 Omicron Sublineages BA.1 and BA.2

SARS-CoV-2 오미크론 하위 계통 BA.1 및 BA.2에 대한 허가된 단일 클론 항체 및 항바이러스제의 효능

Article

Published on 2022-06-232022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, 치료제,

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4 + T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19

장기간의 COVID-19가 있는 항-CD20 치료를 받은 환자에서 높고 지속되는 생체외 빈도이지만 SARS-CoV-2-특이적 CD4 + T-세포의 변경된 표현형

Article

Published on 2022-06-102022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술,

Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies

Research

Published on 2022-06-062022-10-05
Journal: Cell Discovery [Category] 변종, 치료제,

Persistence of immune responses to the Sinopharm/BBIBP-CorV vaccine

Sinopharm/BBIBP-CorV 백신에 대한 면역 반응의 지속성

Article

Published on 2022-06-012022-09-11
Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 age all age groups angiotensin Angiotensin-converting enzyme antibody Antibody Response Antibody responses assays blocking antibodies Cell Cohort COVID-19 declined detectable determine Efficacy ELISPOT ELISpot assays enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Ex vivo group groups Hospitalization immune response immune responses Immunity individual individuals interferon gamma investigated Kinetics long term memory B memory B cell overlapping peptide peptides persistence Protein RBD receptor Receptor-binding domain remained response SARS-CoV-2 second dose severe disease Sinopharm Sinopharm/BBIBP-CorV Spike protein T cell T cell response T cell responses the RBD the receptor-binding domain the spike protein the vaccine total antibodies total antibody Vaccine Vaccines variants variants of concern virus were assessed were measured
[DOI] 10.1002/iid3.621 PMC 바로가기 [Article Type] Article

The paradigm shift in treatment from Covid-19 to oncology with mRNA vaccines

Review article

Published on 2022-06-012022-10-05
Journal: Cancer treatment reviews [Category] COVID19(2023년), SARS, 치료법,

Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs

프로테아제 억제제 Camostat Mesyalte는 인간이 조작한 소형 폐에서 야생형 SARS-CoV-2 및 D614G 바이러스 진입을 차단합니다

Article

Published on 2022-06-012022-09-11
Journal: Biomaterials [Category] Coronavirus, COVID19(2023년), SARS, 치료제,

[키워드] 3D model alveolar alveolar epithelial cell AT2 block camostat catastrophic cell line cell lines COVID-19 Culture D614G develop distal Effect epithelial epithelial cells evaluate Ex vivo highlight human lung in vitro model induce Infection inhibitor involved lentivirus lung lung epithelium maturation moderate organ organ culture organoids pandemic Pathogenesis pathogenesis of COVID-19 phenotype platform pluripotent stem cell Prevent progression Protease inhibitor provided pseudotyped real time reduced Research respiratory tract SARS-CoV-2 SARS-CoV-2 pandemic significantly the SARS-CoV-2 tissue treat type 2 alveolar epithelial cells viral entry viral infection viral infections virulent while wild type wildtype
[DOI] 10.1016/j.biomaterials.2022.121509 PMC 바로가기 [Article Type] Article

Post-COVID-19 Fatigue and SARS-CoV-2 Specific Humoral and T-Cell Responses in Male and Female Outpatients

남성 및 여성 외래 환자의 코로나19 이후 피로 및 SARS-CoV-2 특정 체액 및 T-세포 반응

Article

Published on 2022-05-262022-09-12
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] acute COVID-19 acute infection Analysis assessment both sexes Clinical characteristics conducted Course COVID-19 development disease ELISA ELISPOT enzyme-linked immunosorbent evaluate Ex vivo examined fatigue female Germany humoral IFN-γ IFNγ IgG antibody IL-2 individual Inflammation interferon-γ Level male median time men mild infection not differ Outpatient outpatients participant pathophysiological mechanism producing response SARS-CoV-2 SARS-CoV-2-specific T-cell response scale Serum level significantly significantly lower Specific suffered T-cell T-cell Response T-cells treated university were measured women
[DOI] 10.3389/fimmu.2022.902140 PMC 바로가기 [Article Type] Article

Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses

임상적으로 승인된 약물인 Acriflavine은 SARS-CoV-2 및 기타 베타 코로나바이러스를 억제합니다.

Article

Published on 2022-05-192022-09-11
Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 신약개발, 치료제,

Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity

장기 allo-HSCT 생존자에서 백신 접종 후 SARS-CoV-2 T-세포 반응의 결핍은 체액성 면역 감소로 해석됩니다

Article

Published on 2022-05-102022-09-11
Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Amino acid analyzed anti-RBD BNT162b2 Control coronavirus COVID-19 COVID-19 vaccines death deficiency detectable determine disease Ex vivo Fisher Fisher's exact test healthy control hematological Hematopoietic stem cell HSCT Humoral immunity humoral responses IgG immunogenicity Immunoglobulin Immunoglobulin G interferon interferon-γ lack median mRNA mRNA-1273 Odds ratio of BNT162b2 overlap Patient peptide peptides rate of seroconversion RBD reactivity Receptor binding domain recipient recipients reflected respiratory risk S1 IgG SARS-CoV-2 second vaccination Seroconversion seronegative serum severe acute respiratory syndrome Coronavirus severe disease significantly lower stem cell Stem cell transplantation stimulated substandard survivor T-cell T-cell immunity T-cell Response T-cell responses translate transplantation vaccination Vaccinations vaccine dose Whole blood
[DOI] 10.1182/bloodadvances.2021006937 PMC 바로가기 [Article Type] Article