Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysisArticle Published on 2021-11-292022-10-04 Journal: NPJ Parkinson's Disease [Category] 바이오마커, [키워드] Analysis Anti-inflammatory anti-inflammatory effect association Biomarker covariate CSF Exploratory analysis group groups healthy control include marker multiple comparisons not significantly different Parkinson's Disease Parkinson’s disease partial least square Patient Protein Replication significantly study population Support [DOI] 10.1038/s41531-021-00247-x PMC 바로가기 [Article Type] Article
Low Incidence of COVID-19 Infection in Patients with Acute Myeloid Leukemia Undergoing Reduced Intensity/Venetoclax Based Treatment: Initial Results of the PACE Prospective Clinical Study from the UK Trials Acceleration ProgramConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 유전자 메커니즘, 임상, 치료법, [키워드] acceleration AML Analysis Asymptomatic BMS board Celgene Chemotherapy clinical clinical study clinical trial Cohort cohort of patient concerning conducted Coronavirus disease 2019 cough COVID-19 COVID-19 infection cure death defined determine Diagnosis disease download education employment estimate exacerbated Exploratory analysis Fever figure Follow-up funding Hematological malignancy higher risk hospital immune response Immunosuppression incidence incidence of COVID-19 increasingly indicate Infection information intensity Intensive Jazz MDs median age myelodysplasia myeloid Non-COVID-19 Occurrence outcome pandemic Patient patient hospitalization patients patients treated Patients with cancer PCR test positive presenting symptom Program proportion Prospective provide receiving recruited reduce regimen regimens required Result resulting risk of COVID-19 risk of death SARS-CoV2 secondary severity speaker suffered Support table Takeda tested treated patients Treatment treatment arm treatment history vaccination venetoclax were infected [DOI] 10.1182/blood-2021-146061 [Article Type] Conference abstract
Does COVID-19 infection change the need for future surgical interventions? An exploratory analysis.Brief Report Published on 2021-11-172022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 95%CI adjusted appear baseline Canada Cohort collected data conducted Confidence intervals control group COVID-19 COVID-19 infection disease exclusion Exploratory analysis hazard ratio identify individual Infection performed reduced reduced risk renal Renal stone disease reported retrospective cohort study SARS-CoV-2 significantly surgery surgical Surgical Procedure Swab transurethral Treatment [DOI] 10.12688/f1000research.74861.1 PMC 바로가기 [Article Type] Brief Report
The Impact of Vedolizumab on COVID-19 Outcomes Among Adult IBD Patients in the SECURE-IBD RegistrySECURE-IBD 레지스트리에서 성인 IBD 환자의 COVID-19 결과에 대한 베돌리주맙의 영향Article Published on 2021-11-082022-09-12 Journal: Journal of Crohn's & colitis [Category] MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval adjusted odds ratio anti-TNF appear bowel Care comparable coronavirus disease Coronavirus disease 2019 covariates COVID-19 COVID-19 hospitalization Crohn’s disease determine Exploratory analysis Gastrointestinal symptom Hospitalization IBD Impact Inflammatory bowel disease International mechanical ventilation medication monotherapy multivariable analysis Necrosis outcome outcomes Patient patients patients with COVID-19 registry Safe severe COVID-19 Therapies therapy ulcerative ulcerative colitis vedolizumab [DOI] 10.1093/ecco-jcc/jjab071 PMC 바로가기 [Article Type] Article
LB6. Asymptomatic Infection and Duration of Viral Shedding in Symptomatic Breakthrough Infections in a Phase 3 Study of AZD1222 (ChAdOx1 nCoV-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] 95% CI agreement Analysis AstraZeneca Asymptomatic asymptomatic infection AZD1222 Breakthrough infection Brett CDC criteria ChAdOx1 ChAdOx1 nCoV-19 clearance conducted COVID-19 COVID-19 symptom COVID-19 vaccine criteria Critical cumulative defined demonstrated doses DSMB Duration Efficacy Elizabeth employee Exploratory analysis Fee figure foundation funding highlighting implication Inc incidence Infection Jackson janssen material Merlin NIH Novavax nucleocapsid Other pandemic participant per 1000 person-year Pfizer phase Placebo placebo-controlled study positive RT-PCR Randomized reducing Result Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine second dose Seroconversion shedding statistical Stephanie Support symptomatic symptomatic infection symptomatic infections table the primary endpoint viral clearance viral shedding Viral transmission was determined [DOI] 10.1093/ofid/ofab466.1637 PMC 바로가기 [Article Type] Poster Abstracts
Adapting the UK Biobank Brain Imaging Protocol and Analysis Pipeline for the C-MORE Multi-Organ Study of COVID-19 SurvivorsNeurology Published on 2021-10-292022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] acquisition Analysis Anatomy Anosmia automated Brain brain magnetic resonance imaging (MRI) contribute Control controls COVID-19 COVID-19 patient diffusion discharge disease Effect Exploratory analysis groups Health imaging include intensity medium MRI multi-organ MRI Multiorgan multiple organs olfactory olfactory bulb organ Oxford phenotype protocol recovered COVID-19 patient SARS-CoV-2 SARS-COV-2 infection severity shown small vessel susceptibility tissue UK biobank UK Biobank (UKB) Volume was performed [DOI] 10.3389/fneur.2021.753284 PMC 바로가기 [Article Type] Neurology
Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated VaccinesSARS-COV-2 계통 클러스터 B.1.1.7 아데노 바이러스-벡터 및 비활성화 백신으로 예방 접종 후 감염Article Published on 2021-10-222022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Adenovirus-vectored vaccine Asymptomatic individuals B.1.1.7 B.1.1.7 variant Breakthrough infection caused ChAdOx1 Cluster CoronaVac COVID-19 death dose Exploratory analysis Factor Hospitalization immunized Inactivated vaccine independent individual infect infected individuals Infection Mortality nasopharyngeal sample Nasopharyngeal samples neutralizing capacity outbreak PCR-positive reduce risk SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 RNA SARS-CoV-2-infected individual serum severe disease single dose Single-dose symptomatic the vaccine the vaccines These data Transmissibility vaccination Vaccine variant variant of concern VoC [DOI] 10.3390/v13112127 PMC 바로가기 [Article Type] Article
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil브라질에서 순환하는 SARS-COV-2 계통에 대한 Chadox1 NCOV-19 (AZD1222) 백신의 효능Clinical Trial Published on 2021-10-062022-08-13 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, [키워드] 95% CI Analysis AZD1222 B.1.1.28 Brazil caused ChAdOx1 ChAdOx1 nCoV-19 circulating clinical trials COVID-19 COVID-19 vaccine determine E484K Efficacy Efficiency Exploratory analysis Gamma genotyping hospitalisation Infectious diseases ISRCTN89951424 Lineage lineages Mutation nose nose and throat Nose and throat swabs occurred other variants P.1 P.2 PCR performed phase post-hoc analysis post-hoc exploratory analysis PROTECT protection provided raise Randomised trial SARS-CoV-2 SARS-CoV-2 lineage Sequencing shown Spike protein Swab swabs symptomatic symptomatic COVID-19 symptomatic participants tested the spike protein throat swab Trial Trial registration Vaccine vaccine efficacy vaccine trial Vaccines variant variants variants of SARS-CoV-2 viral infection Zeta [DOI] 10.1038/s41467-021-25982-w PMC 바로가기 [Article Type] Clinical Trial
Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March–October 2020: An exploratory analysisResearch Article Published on 2021-10-062022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Analysis association baseline Characteristics collected Combination convalescent plasma Czech Republic dataset Dexamethasone early phase Efficacy Evidence Exploratory analysis external validation Favipiravir hospital Hydroxychloroquine marker outcome pandemic Patient patients hospitalized performed pharmacological treatment positive predictor prognostic model progression Remdesivir required retrospective SARS-CoV-2 severity statistical model Support tested treated Treatment [DOI] 10.1371/journal.pone.0245103 PMC 바로가기 [Article Type] Research Article
COVID-19 mortality with regard to healthcare services availability, health risks, and socio-spatial factors at department level in France: A spatial cross-sectional analysisResearch Article Published on 2021-09-172022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] Analysis association autocorrelation bias risk concerning coronavirus COVID-19 COVID-19 mortality COVID-19 pandemic cross-sectional cross-sectional analysis cumulative mortality death dissemination Drivers ecological Epidemic example Exploratory analysis Factor Factors First wave FIVE form France Health Health services healthcare service hospital hospitals independent variables inherent lack limitation outcome performed physician positive Region regions regression models risk factor Risk factors Spread spread to were used Wuhan, China [DOI] 10.1371/journal.pone.0256857 PMC 바로가기 [Article Type] Research Article