Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patientsArticle Published on 2022-08-012022-11-15 Journal: Journal of Extracellular Vesicles [Category] 바이오마커, 유전자 메커니즘, [키워드] antibody biochemical Biomarker Biomarkers CD13 CD24 CD82 Cell characterized circulating Concentration correlated COVID-19 COVID-19 progression COVID-19 severity disease severity Donor driver eight EVs Extracellular extracellular vesicle Extracellular vesicles flow cytometry healthy donor identify IFCM immunological parameters Immunopathogenesis MDSC mechanism Mild mild COVID-19 patient novel Patient positively correlated proinflammatory cytokines sera serum severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity of COVID-19 Sex Support the disease the healthy [DOI] 10.1002/jev2.12257 PMC 바로가기
Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19Observational Study Published on 2022-07-292022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] adjusted age aggravate association BMI Chest computed tomography Chest CT CIRP Cohort Comorbidity Concentration contribute correlated correlation COVID-19 damage-associated molecular pattern DAMP DAMPs defined determine disease dysregulated eCIRP evaluate external validation Extracellular extracellular CIRP FiO2 HFNO High-flow nasal oxygen highest Hospitalized hospitalized patient Host immune response Hypoxemia induce Inflammation inflammatory biomarkers Linear regression lung involvement mechanical ventilation Mild oxygen Pathogenesis Patient patients with COVID-19 peak prospective observational study Protein pulmonary involvement reduce Respiratory failure Respiratory Support risk Sepsis serum Serum level severe COVID-19 severe hypoxemia severity Severity of disease Sex suggested symptom duration tissue injury Treatment uncontrolled university was used were used [DOI] 10.3389/fimmu.2022.945603 PMC 바로가기 [Article Type] Observational Study
Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation Research Published on 2022-07-282022-10-05 Journal: ISME Communications [Category] 변종, 유전자 메커니즘, [키워드] accelerate Acinetobacter Antibiotic resistance antibiotic resistance gene antidepressant antimicrobial Arg ARGs ATP Bupropion cell membrane clinically Concentration demonstrated dissemination Duloxetine Extracellular Fluoxetine Gut Health Human increasingly Interaction microbial community potential risk promote reactive oxygen species Result sertraline significantly SOS response Spread stimulated Stress Transcription transfer translation [DOI] 10.1038/s43705-022-00147-y [Article Type] Research
Updated Living Systematic Review and Meta-analysis of Controlled Trials of Mesenchymal Stromal Cells to Treat COVID-19: A Framework for Accelerated Synthesis of Trial Evidence for Rapid Approval-FASTER ApprovalCOVID-19를 치료하기 위한 중간엽 간질 세포의 통제된 시험에 대한 업데이트된 살아있는 체계적인 검토 및 메타 분석: 신속한 승인-빠른 승인을 위한 시험 증거의 가속화된 합성을 위한 프레임워크Meta-Analysis Published on 2022-07-202022-09-11 Journal: Stem cells translational medicine [Category] 임상, [키워드] accelerate accelerated acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appear approval ARDS Clinical studies clinical study conducted Consistency Control Controlled controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Critical death Endpoint evaluate Evidence Exosomes Extracellular Extracellular vesicles facilitate framework heterogeneity Hospital stay identify IMPROVE ISCT Master protocol mean difference Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells Meta-analysis Microvesicles moderate Mortality MSC MSC-EVs exosomes MSCs non-randomized study outcome Oxygenation Patient Pneumonia PROSPERO protocol random-effect random-effects Random-effects meta-analysis Randomized controlled trial Rapid reduce reduce mortality Relative risk reported respiratory distress Respiratory distress syndrome review risk of bia risk of death RoB SARS-CoV-2 Sepsis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Society stromal cell stromal cells synthesis systematic review treat Treatment [DOI] 10.1093/stcltm/szac038 PMC 바로가기 [Article Type] Meta-Analysis
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics Reviews Published on 2022-07-072022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 신약개발, [키워드] Activation addition biological processes Cancer Cell cell metabolism cell proliferation cellular pathways change Chronic diseases disease Diseases downstream gene drugs Endoplasmic reticulum ERK expression Extracellular Factor Glycolysis Health hypoxia immune response implication Infection interact involved kinase mammalian cells mechanism Metastasis microbe Molecular oxygen NF-κB nuclear oxygen pathogenic pathway question Rapamycin reaction regulate respond responses Signaling Stress subsequent therapeutic therapeutic target tumorigenesis [DOI] 10.1038/s41392-022-01080-1 [Article Type] Reviews
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans Research Published on 2022-07-042022-10-05 Journal: Nature Structural & Molecular Biology [Category] 변종, [키워드] binding Candida albican chitin conserved Control cryo-EM structure enzyme activity Extracellular fungal cell wall inhibitor mechanism membrane motif non-specific Prevent Regulation Synthase target translocation unique [DOI] 10.1038/s41594-022-00791-x [Article Type] Research
Overhydration Assessed Using Bioelectrical Impedance Vector Analysis Adversely Affects 90-Day Clinical Outcome among SARS-CoV2 Patients: A New Approach생체 전기 임피던스 벡터 분석을 사용하여 평가된 과수화는 SARS-CoV2 환자의 90일 임상 결과에 부정적인 영향을 미칩니다: 새로운 접근 방식Article Published on 2022-06-302022-09-11 Journal: Nutrients [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95%CI Admission Affect assessment assist Biomarker body water Care clinical clinical assessment COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients creatinine cut-off value determine Extracellular extracellular water greater highest Hospital admission Hydration hydration fat-free mass hydration status ICU identify impedance increased mortality indicated Inflammation intensive care unit Laboratory marker measure Medical care medical condition Mortality Multivariate analysis New offer Overhydration pandemic parameters Patient poor prognosis prealbumin predict Predictive predictor prognostic Prognostic factors proportion Research risk risk factor SARS-CoV2 sensitivity significantly significantly higher specificity survival survival and mortality analysis total body total body water total body water. vector water [DOI] 10.3390/nu14132726 PMC 바로가기 [Article Type] Article
Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot [DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope35B5 항체는 보존된 스파이크 에피토프를 통해 N-글리칸 스위치를 방해하여 SARS-CoV-2 Omicron을 강력하게 중화합니다.Article Published on 2022-06-082022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 35B5 ACE2 antibody antigenic antigenic shift change changes conformational change conserved Control cryo Cryo-electron microscopy disrupting dissociation domain Efficacy electron microscopy entry receptor epitope exhibit Extracellular Fab glycan Host immune evasion Microscopy monoclonal monoclonal antibody Mutation N-terminal domain neutralization neutralize Neutralizing Neutralizing antibodies neutralizing capacity not affect NTD omicron other variant other variants RBD Receptor-binding domain Recognition SARS-CoV-2 Spike protein Structure the RBD the spike protein therapeutic transition trimer trimeric variant [DOI] 10.1016/j.chom.2022.03.035 PMC 바로가기 [Article Type] Article
The life cycle and enigmatic egress of coronaviruses코로나바이러스의 수명 주기와 불가사의한 탈출Review Published on 2022-06-012022-09-11 Journal: Molecular microbiology [Category] COVID19(2023년), SARS, 치료법, [키워드] adopted alternative route causative agent Cell cell surface cellular Consensus coronavirus CoV CoV infection CoV replication COVID-19 pandemic CoVs drugs Endoplasmic reticulum expression Extracellular genome replication genomic RNA Golgi Golgi apparatus host cell host cells Interference life cycle lumen membrane envelope mobilization nucleocapsid nucleocapsid protein Nucleocapsid proteins pandemic pathway progeny promote Protein rab1 rab11 respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown situation the Golgi apparatus the intermediate compartment (IC) the recycling endosome (RE). therapeutic virion assembly virus [DOI] 10.1111/mmi.14907 PMC 바로가기 [Article Type] Review