SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular DynamicsMolecular Biosciences Published on 2022-02-142022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] accelerated association bind binding site Cluster conformational COVID-19 docking Dynamics Extracellular matrix free energy landscape hindrance host receptor Hypothesis integrin Integrins Interaction microenvironment molecular molecular dynamcis motif normal mode analysis Protein RBD residue SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 virus sequence spike the RBD Validity viruses [DOI] 10.3389/fmolb.2022.834857 PMC 바로가기 [Article Type] Molecular Biosciences
A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk Research Published on 2022-02-142022-10-05 Journal: Nature [Category] 유전자 메커니즘, [키워드] adaptive Alzheimer’s disease blood flow Brain cause Cell cell type cell types Cognitive impairment continuum develop disease dysfunction dysregulated ECM endothelial expressed Extracellular matrix fibroblast gene expression pattern Genome-wide association study GWAS GWASs Health identify immune immunostaining individual Isolation mice molecular molecular basis nuclei observé Pathways pericyte pericytes perivascular Protein reveal risk selective Sequencing subtype therapy Transcriptome transfer Transport Treatment Vascular vasculature vessel [DOI] 10.1038/s41586-021-04369-3 [Article Type] Research
Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection RecapitulationResearch Article Published on 2022-02-042022-10-29 Journal: Research [Category] COVID-19, [키워드] alveolar antibody caused Characteristics develop Extracellular matrix human lung in vitro morbidity and mortality organ pandemic pathophysiology physiological platform provide pseudovirus SARS-CoV-2 SARS-CoV-2 pathogenesis severe pneumonia viral infection virus pathogenesis [DOI] 10.34133/2022/9819154 PMC 바로가기 [Article Type] Research Article
Understanding the tuberculosis granuloma: the matrix revolutionsReview Published on 2022-02-012023-07-07 Journal: Trends in molecular medicine [Category] COVID19(2023년), [키워드] bioinformatic analysis Extracellular matrix granuloma Metalloprotease Tuberculosis [DOI] 10.1016/j.molmed.2021.11.004 PMC 바로가기 [Article Type] Review
The “Elastic Perspective” of SARS-CoV-2 Infection and the Role of Intrinsic and Extrinsic FactorsReview Published on 2022-01-292022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Activation affected blood vessel Cell consequence contributing to COVID-19 COVID-19 patients crosslinked Degradation Elastase elastin enzyme Extracellular matrix extracellular space extrinsic Factor impairment Inflammation inflammatory conditions insoluble intrinsic lung Lungs monomer NET neutrophil Neutrophils Protein proteolytic Pulmonary function recruitment responsible role SARS-CoV-2 SARS-COV-2 infection secrete severity Spread tissue [DOI] 10.3390/ijms23031559 PMC 바로가기 [Article Type] Review
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력Clinical Trial Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제, [키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used [DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial
Epigenetic Changes and Functions in PneumoconiosisReview Article Published on 2022-01-202022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] Coronavirus, [키워드] accompanied alveolar epithelial cells Cell change changes characterized Clarifying coronavirus disease disease DNA methylation epidemiological Epigenetic Evidence Extracellular matrix Factor fibroblasts fibrosis function in vitro experiments in vivo inhibit Lung disease lung tissue macrophages noncoding RNA Occurrence Pathogenesis pneumoconiosis promote pulmonary pulmonary fibrosis specific treatment therapeutic target Treatment turn [DOI] 10.1155/2022/2523066 PMC 바로가기 [Article Type] Review Article
Identification of hub genes associated with COVID-19 and idiopathic pulmonary fibrosis by integrated bioinformatics analysisResearch Article Published on 2022-01-192022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] acute respiratory syndrome Bioinformatics analysis candidate drug caused coronavirus coronavirus disease COVID-19 cytokine Cytoscape dataset datasets DEGs determine differentially expressed gene downregulated enrichment analysis Extracellular matrix FIVE Genes GEO database identification identify identifying involved IPF material performed PPI predicted progression protein-protein interaction pulmonary fibrosis regulated reported Result risk factor SARS-CoV-2 SARS-CoV-2 infections therapeutic target upregulated with COVID-19 [DOI] 10.1371/journal.pone.0262737 PMC 바로가기 [Article Type] Research Article
COVID-19: Immunohistochemical Analysis of TGF-β Signaling Pathways in Pulmonary FibrosisArticle Published on 2021-12-242022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, 신종인플루엔자, [키워드] ACE-2 activated addition alveolar ARDS Biomarker causes consequence COVID-19 COVID-19 group DAD died Diffuse alveolar damage distress ECM evaluated Evidence expression Extracellular matrix fibroblast fibrosis H1N1 H1N1pdm09 histopathological feature IL-4 immature immunoexpression inhibitor involved lung Lung injury mitigate pathway Patient promote pulmonary pulmonary fibrosis regulate SARS-CoV-2 septal signaling pathway significant increase significantly increased significantly lower syndrome TGF-β TGF-β TGF-β1 therapy tissue tissue expression [DOI] 10.3390/ijms23010168 PMC 바로가기 [Article Type] Article
Heparin and SARS-CoV-2: Multiple Pathophysiological LinksReview Published on 2021-12-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] adopted Anticoagulant bleeding bleedings condition COVID-19 dose drug Extracellular matrix fondaparinux heparin heparins ICU ICUs increased risk Inpatient intensive care unit low molecular weight heparin molecular weight Multiple oligosaccharide pandemic Prevent prolonged administration recognize recorded reported respiratory tract the SARS-CoV-2 therapeutic dose underlying disease Venous Thromboembolism virus VTE with COVID-19 [DOI] 10.3390/v13122486 PMC 바로가기 [Article Type] Review