Genetically Engineered MRI-Trackable Extracellular Vesicles as SARS-CoV-2 Mimetics for Mapping ACE2 Binding In VivoArticle Published on 2022-08-232022-11-16 Journal: ACS Nano [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor approach binding complex coronavirus event EVs Extracellular extracellular vesicle Genetic genetic engineering hazard in vivo Interaction interactions ligand−receptor binding mapping mechanism MRI Mutagenesis mutant pandemic pathogenic virus platform predicted Protein raised RBD Receptor binding domain Safe SARS-CoV-2 subjects superparamagnetic iron oxide nanoparticles (SPIONs) the RBD tissues variant virus virus mimetics. viruses [DOI] 10.1021/acsnano.2c03119 PMC 바로가기
Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples Research Published on 2022-08-192022-10-05 Journal: Nature biomedical engineering [Category] 바이오마커, 임상, 진단, [키워드] assays blood sample children circulating cohort study detect diagnoses extracellular vesicle Extracellular vesicles facilitate Factor Hospitalized immunoassay Immunosuppressed Infection Microscopy Mycobacterium tuberculosis non-human primates operable point of care Protein reduce mortality sensitive Tuberculosis virulence with HIV [DOI] 10.1038/s41551-022-00922-1 [Article Type] Research
The roles of extracellular vesicles in the immune system Reviews Published on 2022-08-042022-10-05 Journal: Nature reviews. Immunology [Category] 바이오마커, 유전자 메커니즘, 임상, 치료제, [키워드] Activation adaptive allergic Antigen presentation Autoimmune B cell Biomarker clinical trial criteria EVs Extracellular extracellular vesicle greater highlight immune responses immune system Immunity Immunotherapy Inflammation Research review T cells therapeutic therapeutic potential vaccination Vesicle [DOI] 10.1038/s41577-022-00763-8 [Article Type] Reviews
Risk stratification of patients with SARS-CoV-2 by tissue factor expression in circulating extracellular vesiclesArticle Published on 2022-08-012022-11-15 Journal: Vascular pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] 4C mortality score Accuracy assays AUC Biomarker CD142 circulating clinical decision clinically Cohort comparable correlated Course COVID-19 COVID-19 patients diagnostic enrolled evaluated EVs expressing expression extracellular vesicle Extracellular vesicles hospital independent Kaplan-Meier curve majority molecular test Mortality Patient patients with SARS-CoV-2 Pneumonia positive predict Prognosis prognostic Prognostic marker reliability risk risk stratification SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 selected Stratification study population subject Support the disease tissue Tissue Factor validation cohort [DOI] 10.1016/j.vph.2022.106999 PMC 바로가기
Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patientsArticle Published on 2022-08-012022-11-15 Journal: Journal of Extracellular Vesicles [Category] 바이오마커, 유전자 메커니즘, [키워드] antibody biochemical Biomarker Biomarkers CD13 CD24 CD82 Cell characterized circulating Concentration correlated COVID-19 COVID-19 progression COVID-19 severity disease severity Donor driver eight EVs Extracellular extracellular vesicle Extracellular vesicles flow cytometry healthy donor identify IFCM immunological parameters Immunopathogenesis MDSC mechanism Mild mild COVID-19 patient novel Patient positively correlated proinflammatory cytokines sera serum severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity of COVID-19 Sex Support the disease the healthy [DOI] 10.1002/jev2.12257 PMC 바로가기
Proteomic Profile of Procoagulant Extracellular Vesicles Reflects Complement System Activation and Platelet Hyperreactivity of Patients with Severe COVID-19응고촉진 세포외 소포의 단백질 프로파일은 중증 COVID-19 환자의 보체 시스템 활성화 및 혈소판 과민반응을 반영합니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute inflammatory response alteration analyzed applied approach biological processe biological processes Biomarker Biomarkers cascades caused change changes in circulating Coagulation complement complement factors computational analysis COVID-19 COVID-19 patients Cytometry degranulation disease pathogenesis Diseases EVs experiment expressed extracellular vesicle Extracellular vesicles Flow flow cytometry group healthy donor healthy donors identify increase in indicated infected with SARS-CoV-2 LC-MS LC-MS/MS molecular pathophysiological Patient plasma Platelet Platelets procoagulant procoagulant activity profile progression Protein proteome proteomic SARS-CoV-2 SEC severe COVID-19 severe COVID-19 patients severity of COVID-19 significant changes in size exclusion chromatography System the disease tissue Tissue Factor total protein Vesicle was performed [DOI] 10.3389/fcimb.2022.926352 PMC 바로가기 [Article Type] Article
Inhalable dry powder mRNA vaccines based on extracellular vesiclesResearch article Published on 2022-07-112022-10-05 Journal: Matter [Category] 비임상, [키워드] Bioavailability Bronchiole carriers circumvent COVID-19 death disease distribution dry powder inhalation elicited exhibited Exosome Exosomes extracellular vesicle Extracellular vesicles functional greater IgG illness Immunoglobulin Inhaled limitation limitations Liposome lung mRNA mRNA vaccine NHPs nonhuman primate Protein remained respiratory Respiratory Coronavirus response rodent SARS-CoV-2 secretory IgA SIgA Spike protein stability Therapeutics Vaccine [DOI] 10.1016/j.matt.2022.06.012 [Article Type] Research article
Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients더 나쁜 질병 예후는 입원한 SARS-CoV-2 환자에서 혈소판 유래 세포외 소포의 증가와 관련이 있습니다Article Published on 2022-07-072022-09-11 Journal: Disease Markers [Category] COVID19(2023년), SARS, 치료기술, [키워드] applied Biomarker Blood circulating Cohort COVID-19 enrolled Evolution EVs extracellular vesicle Extracellular vesicles flow cytometry healthy controls heparin Hospital admission Hospitalization human diseases increase Italy not affected occurred outcome Patient patients Platelet predict reducing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients steroid Steroids suggested the disease Treatment viral infections WHO guidelines [DOI] 10.1155/2022/8074655 PMC 바로가기 [Article Type] Article
Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? Reviews Published on 2022-07-042022-10-05 Journal: Cell Death & Disease [Category] 바이오마커, [키워드] adipose body fluid Bone marrow Cell Characteristics effector Evidence EVs extracellular vesicle fibrosis heterogeneity highlight immune regulation Intercellular communication mesenchymal stem cell molecular mechanism MSC MSCs overcome paracrine supernatants Support therapeutic therapeutic effect therapy tissue tissue repair Treatment umbilical various tissue Vesicle [DOI] 10.1038/s41419-022-05034-x [Article Type] Reviews
Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial CellsCOVID-19 환자의 순환 엑소좀은 내피 세포에서 NLRP3 인플라마좀을 유발합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation of caspase-1 acute respiratory syndrome acute respiratory syndrome coronavirus augmentation blood flow cargo caspase caspase-1 Cell Circulatory Coagulation Coagulopathy combating Control coronavirus coronavirus 2 COVID-19 Culture culture medium Cytokine storm demonstrated drug endothelial Endothelial cell endothelial cells ENhance examined Exosome Exosomes exposure to extracellular vesicle Extracellular vesicles Health health problem healthy donors help highlight IL-1β Immunopathogenesis induce Infection Inflammasome Inflammation Inflammatory response inhibit interleukin interleukin-1β investigator liver mechanism medium Mild Mild disease molecular molecular mechanism mRNA expression Multiple organ damage NLRP3 NLRP3 inflammasome opens organ organ damage Pathogenesis Patient plasma predicted Prevent respiratory resting resulting SARS-CoV-2 SARS-COV-2 infection secretion Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients significantly the vaccine Therapies Trigger Vaccine Venous Thromboembolism with mild disease [DOI] 10.1128/mbio.00951-22 PMC 바로가기 [Article Type] Article