Validation of remote height and weight assessment in a rural randomized clinical trialRandomized Controlled Trial Published on 2022-07-112022-10-05 Journal: BMC Medical Research Methodology [Category] 임상, [키워드] analyses Analysis BMI body mass body mass index children clinical clinical trial clinical trials clinically coefficient conducted difference examined family feasible Height Impact mean difference measure pandemic protocol provided randomized clinical trial ranged remote Remote assessment Result rural Trial validation weight [DOI] 10.1186/s12874-022-01669-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
B cell-derived cfDNA after primary BNT162b2 mRNA vaccination anticipates memory B cells and SARS-CoV-2 neutralizing antibodies1차 BNT162b2 mRNA 백신 접종 후 B 세포 유래 cfDNA는 기억 B 세포 및 SARS-CoV-2 중화 항체를 예상합니다Article Published on 2022-07-082022-09-12 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] actual acute respiratory syndrome adaptive administration Alex B cell BNT162b2 BNT162b2 mRNA vaccination booster Booster vaccine cell count cell-free DNA cellular center cfDNA chair circulating Coronavirus-2 correlated demonstrated DNA DNA methylation dose effective family foundation heart Human humoral immune cell type immune system Immunity innate immune cell liquid biopsy lymphocyte counts Medicine memory memory B cell memory B-cell monocyte mRNA mRNA vaccine network Neutralizing neutralizing antibody neutrophil Pfizer/BioNTech Program reduction in remained response Robert SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccine Science supported T cell tissue tissue dynamics. Translation to patients Trust university vaccination Vaccine [DOI] 10.1016/j.medj.2022.05.005 PMC 바로가기 [Article Type] Article
Long-term Immune Response to SARS-CoV-2 Infection Among Children and Adults After Mild Infection경증 감염 후 소아 및 성인의 SARS-CoV-2 감염에 대한 장기 면역 반응Article Published on 2022-07-012022-09-12 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age Analysis anti-SARS-CoV-2 antibody Asymptomatic chemiluminescent immunoassay children clinic Cluster Cohort cohort study COVID-19 COVID-19 vaccination demonstrated Department enrolled Evidence family Follow-up follow-up time help IgG IgG titer immune response individual Infection Italian longitudinal median Mild Older older patient parent Patient pediatric persistence prospective cohort study provide quantification response S-RBD SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection significantly higher single-center spike receptor-binding domain study participant Study participants sustained understanding university Vaccination strategies [DOI] 10.1001/jamanetworkopen.2022.21616 PMC 바로가기 [Article Type] Article
Reduced fixed dose tocilizumab 400 mg IV compared to weight-based dosing in critically ill patients with COVID-19: A before-after cohort studyResearch article Published on 2022-07-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 바이오마커, [키워드] 28-day mortality assumed benefit Clinical outcome Cohort cohort study comparable cost-effectiveness Covid cytokine storm COVID-19 COVID-19 patient Critically ill Critically ill patient CRP demonstrated Dexamethasone dose equity family feasible finding fixed dose foundation funding groups Inflammation inhibitor interleukin-6 no significant difference pair-wise comparison Patient patients physiological response receiving reduce mortality reduction response Scholarship severe COVID-19 supported Taylor the patient threshold Tocilizumab treated with COVID-19 [DOI] 10.1016/j.lana.2022.100228 [Article Type] Research article
Patient perspectives on window of opportunity clinical trials in early-stage breast cancer초기 유방암에서 임상 시험 기회의 창에 대한 환자의 관점Article Published on 2022-07-012022-09-11 Journal: Breast cancer research and treatment [Category] 임상, [키워드] absence altruism Analysis anti-cancer treatment approach barrier benefit Breast Breast cancer Cancer clinic clinical clinical trial clinical trials contribute COVID-19 COVID-19 pandemic Decision-making desire diagnosed Diagnosis drug Enrollment Factor family fitness Hope hypothetical identify increasingly indicated offered oncology participant Participation Patient Patient perspectives performed Perspective positive attitude receive recruited Research Side effect Side effects standard treatment therapy Treatment Trial weighed window Window of opportunity. women [DOI] 10.1007/s10549-022-06611-6 PMC 바로가기 [Article Type] Article
Family caregivers’ concerns about advance care planning for home-dwelling people with dementia: a cross-sectional observational study in JapanObservational Study Published on 2022-06-272022-10-05 Journal: BMC Palliative Care [Category] 임상, [키워드] Administered advance advance care planning Attitudes Care Characteristics concerning cross-sectional Dementia family Family caregiver inclusion criteria individual initiated investigated involved Japan Older palliative Palliative care participated professional psychological need Psychological well-being questionnaire reported respondent significantly higher significantly lower WHO-5 Well-being Index [DOI] 10.1186/s12904-022-01008-0 PMC 바로가기 [Article Type] Observational Study
Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot [DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
The Lived Experience of Physical Separation for Hospice Patients and Families amid COVID-19COVID-19 속에서 호스피스 환자와 가족을 위한 육체적 이별의 생생한 경험Article Published on 2022-06-012022-09-11 Journal: Journal of pain and symptom management [Category] 임상, [키워드] Analysis analyzed Care Care plan Caregivers clinical trial collected connection COVID-19 COVID-19 pandemic dataset effective emotional End-of-life care experience family Final functional Healthcare professional healthcare professionals hospice hospices Intervention life limit participated Patient patients Patients with cancer performed physical physically provided public health qualitative data separated separation social isolation spring thematic analysis transcribed Transmission [DOI] 10.1016/j.jpainsymman.2022.02.019 PMC 바로가기 [Article Type] Article
[Ways of supporting relatives in intensive care units : Overview and update]Review Published on 2022-06-012023-07-08 Journal: Medizinische Klinik, Intensivmedizin Und Notfallme [Category] COVID19(2023년), [키워드] communication COVID-19 family Pandemics Psychological stress [DOI] 10.1007/s00063-022-00915-7 PMC 바로가기 [Article Type] Review
Recommendations for the Outpatient Drug Treatment of Patients With COVID-19Article Published on 2022-05-132022-11-15 Journal: Deutsches Ärzteblatt international [Category] 진단, [키워드] Acetylsalicylic acid carried Clinical efficacy clinically Colchicine college concerning conducted Consensus Course COVID-19 COVID-19 outpatient COVID-19 patient dose drug drug treatment early phase Elderly patient Evidence expected family general practitioner high risk Hospitalization in vitro Infection Ivermectin off-label offered Outpatient Patient patient selection physician Prevent primary care Prophylaxis Randomized controlled trial recommendation reduced Remdesivir response to vaccination retrieved risk risk factor severe disease course systemic steroids the disease treated Treatment treatment for COVID-19 Trial with COVID-19 [DOI] 10.3238/arztebl.m2022.0203 PMC 바로가기