A(H1N1)pdm09 Influenza Viruses Replicating in Ferret Upper or Lower Respiratory Tract Differed in Onward Transmission Potential by AirArticle Published on 2022-01-012023-06-14 Journal: The Journal of Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] ferrets Influenza virus Transmission tropism [DOI] 10.1093/infdis/jiab286 PMC 바로가기
Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta베타가 아닌 알파의 SARS-CoV-2 변종에 대한 향상된 적합성Comparative Study Published on 2021-12-222022-09-10 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 airway Alpha Alpha variant angiotensin assessment B.1.1.7 B.1.351 Beta Beta variant COVID-19 pandemic cultures driver driving enhanced epithelial experiment Experimental models of disease expressing ferret ferrets fitness greater hamster hamsters high viral replication highlight human ACE2 human Angiotensin-converting enzyme in vitro in vivo mechanism mice nasal overcome progenitor receptor Replication respiratory SARS-CoV-2 SARS-CoV-2 variant similar replication kinetics Spike protein Substitution substitutions Support the spike protein Transmission upper respiratory tract variant variants of concern Viral viral infection virus VoC VOCs [DOI] 10.1038/s41586-021-04342-0 PMC 바로가기 [Article Type] Comparative Study
Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret modelArticle Published on 2021-12-212023-06-14 Journal: Thrombosis research [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 ferrets mass spectrometry proteomics thrombosis [DOI] 10.1016/j.thromres.2021.12.015 PMC 바로가기 [Article Type] Article
Understanding the prevalence of SARS-CoV-2 (COVID-19) exposure in companion, captive, wild, and farmed animalsReview Article Published on 2021-12-102022-10-28 Journal: Virulence [Category] COVID-19, Fulltext, SARS, 조류인플루엔자, [키워드] 2003 SARS 2019 coronavirus disease acute respiratory syndrome Aerosols cat coronavirus Coronaviruses COVID-19 COVID-19 pandemic COVID-19 vaccine deer demonstrated determine develop dog effort ELISA event Evolution ferrets hamsters Health implication Infection mink natural infection outbreak Outbreaks pandemic Perspective pets Prevalence public health replicate responsible SARS-CoV SARS-CoV-2 SARS-COV-2 infection Seroprevalence shown Surveillance susceptible Transmission dynamics transmissions understanding virus zoonoses zoonotic transmission [DOI] 10.1080/21505594.2021.1996519 PMC 바로가기 [Article Type] Review Article
Enhanced apoptosis as a possible mechanism to self-limit SARS-CoV-2 replication in porcine primary respiratory epithelial cells in contrast to human cellsArticle Published on 2021-12-102022-10-31 Journal: Cell Death Discovery [Category] COVID-19, [키워드] ACE2 expression Activation Analysis Apoptosis apoptotic caspase Cell Clinical sign COVID-19 dose-dependent dose-dependent manner enhanced ferrets former hallmark hamsters Health HREC human cell humans Immune cell death in vivo infect Infection infectious dose investigated less mechanism Microbiology Morphological replicated reported respiratory epithelial cell respiratory epithelial cells SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 replication Seroconversion susceptibility susceptible therapeutic Transmission Treatment viral shedding virus [DOI] 10.1038/s41420-021-00781-w PMC 바로가기 [Article Type] Article
Animal models for SARS‐CoV‐2 infection and pathologyReview Published on 2021-11-162022-10-30 Journal: MedComm [Category] COVID-19, [키워드] accelerate acute respiratory syndrome Analysis animal animal model animal models antiviral drug Appropriate Beta Care Characteristics coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 current Delta etiology ferrets Gamma hamsters Health immune response immunology immunomodulatory Infection Lambda mice pandemic Pathogenesis pathology platform provided robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 therapeutic agents therapeutic drug therapy Transmission Vaccine Vaccines variant [DOI] 10.1002/mco2.98 PMC 바로가기 [Article Type] Review
Surveillance and control of SARS‐CoV‐2 in mustelids: An evolutionary perspectivePerspective Published on 2021-11-062022-10-31 Journal: Evolutionary Applications [Category] COVID-19, [키워드] Adequate American mink animal model biotic hub Community condition European event Evolution Evolution of virulence facilitate farmed mink ferrets global pandemic Human imperative increasingly inherent Intensive introduced measure mitigate occur occurred one health outbreak Outbreaks Perspective reported representing respiratory diseases reverse zoonoses SARS‐CoV‐2 SARS‐CoV‐2 Spread subsequent Surveillance Transmission Viral transmission Viral variants virulence virus zoonotic zoonotic transmission [DOI] 10.1111/eva.13310 PMC 바로가기 [Article Type] Perspective
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferretsremdesivir 부모 GS-441524의 경구 전구 약물은 흰 족제비에서 SARS-COV-2에 대해 효과적입니다.Article Published on 2021-11-052022-08-31 Journal: Nature Communications [Category] MERS, SARS, 변종, 치료제, [키워드] Administered administration animal model anti-SARS-CoV-2 Antiviral Antiviral treatment antivirals approved block boost Cell culture Contact COVID-19 COVID-19 treatment dosed early administration Efficacy ferret ferrets GS-441524 Human airway epithelium inhibit inhibit SARS-CoV-2 intravenous intravenously lung Lungs mechanism metabolite nucleoside oral oral administration oral bioavailability organoids parent nucleoside patients plasma Prevent prodrug reduce Remdesivir SARS-CoV-2 SARS-COV-2 infection Therapeutic benefit therapeutic efficacy Transmission Treatment triphosphate variants variants of concern virus replication VoC [DOI] 10.1038/s41467-021-26760-4 PMC 바로가기 [Article Type] Article
Development of an Inactivated Vaccine against SARS CoV-2SARS COV-2에 대한 불활성 백신의 개발Article Published on 2021-11-022022-09-10 Journal: Vaccines [Category] 비임상, [키워드] Adenovirus Aluminium aluminium hydroxide animal models approved AstraZeneca BALB/c mice breath candidate candidate vaccine changed clinical development clinical trial Complete COVID-19 COVID-19 pandemic COVID-19 vaccine develop development Device distribution Efficacy elicited Emergency use ERUCoV-VAC ferrets hACE2 HCoV help human clinical trial human clinical trials hydroxide immunogenic immunogenicity inactivated Inactivated vaccine include Johnson & Johnson K18-hACE2 Medical devices Medicine mice Moderna mRNA name outbreak Pfizer-BioNTech Phase 3 phase 3 clinical trial progression Protective respiratory safety evaluation SARS CoV-2 SARS-CoV-2 SARS-CoV-2 vaccine Sinopharm Sinovac Spread strain strong immune response the vaccine the WHO transgenic mice TURKOVAC university upper respiratory tract upper respiratory tracts Vaccine vaccine candidate Vaccines Viral viral clearance rate Viral vector viral vectors was used [DOI] 10.3390/vaccines9111266 PMC 바로가기 [Article Type] Article
Antiviral effects of human placenta hydrolysate (Laennec ®) against SARS-CoV-2 in vitro and in the ferret model시험관 내 및 흰 족제비 모델에서 SARS-CoV-2에 대한 인간 태반 가수분해물(Laennec®)의 항바이러스 효과Comparative Study Published on 2021-11-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] SARS, 치료제, [키워드] addition Antiviral Antiviral effect antiviral effects antiviral efficacy Attenuated Virus caused clinical manifestation COVID-19 COVID-19 pandemic COVID-19 treatment cytokine Cytokines determine determined by disease dose-dependent manner Effect effective FDA-approved drug ferret ferrets Gene Expression group Health health condition Human Hyperferritinemia IFN IFN-α IFN-β IFN-γ IMPROVE in vitro in vivo model Infection inhibited interferon Laennec® lung Lungs MOI mRNA expression nasal Patient PBS Placenta qRT-PCR Remdesivir respiratory tract respiratory tracts Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selective shown TCID therapeutic therapeutic agent treated Treatment type I upregulated Vero Cell Vero cells virus replication virus titer virus titers was determined [DOI] 10.1007/s12275-021-1367-2 PMC 바로가기 [Article Type] Comparative Study