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[키워드] A20 A549 activated acute respiratory distress adjust approach ARDS attenuate Cell cells cellular change characterized chromatin combinations Complete Concentration contribute coronavirus coronavirus coronavirus-infected cells correlated cytoplasm cytoplasmic de novo gene Degradation enhancer enhancer region Epigenetic event example expected expression expression level expression of gene Factor fine-tune Gene Expression Genes genes encoding Genome genome-wide investigation genomic region HCoV-229E HKU1 Host host cell host cell cytoplasm host response human coronavirus 229E humans identify IKK IKKβ IL-1 immunomodulatory factor immunomodulatory function infected cell infections Inflammatory Inflammatory cytokine involved IκBα Lung disease mechanism mechanisms MERS-CoV metabolic processes Modification molecular molecular basis motif NEMO NF-κB NF-κB signaling NL63 nuclear nuclear chromatin nucleus OC43 p65 pathogenic Pathogens pathology promote promoter Protein provide recruited recruitment regulatory region Replication required restrict RNA Polymerase II RNA virus SARS-CoV second shown Signaling subunit syndrome These cells TNFAIP3 transcribed Transcription transcription factor Transcriptome Treatment Trigger upper respiratory tract upregulated gene upregulation variety viral replication virus virus replication Virus-host interactions zoonotic coronavirus
[DOI] 10.1371/journal.ppat.1006286 PMC 바로가기 [Article Type] Research Article