The potential role of procyanidin as a therapeutic agent against SARS-CoV-2: a text mining, molecular docking and molecular dynamics simulation approachSARS-CoV-2에 대한 치료제로서 프로시아니딘의 잠재적 역할: 텍스트 마이닝, 분자 도킹 및 분자 역학 시뮬레이션 접근Article Published on 2022-02-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] ACE2 affinity Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach arise binding energy calculated caused Cluster co-occurrence COVID COVID 19 Critical enzyme flavonoid Frequency Helicase Human hydrogen Hydrogen bond hydrogen bonds hydrophobic hydrophobic interaction hydrophobic interactions identify inhibit Interaction mechanism membrane molecular molecular docking molecular dynamics Molecular dynamics simulation Molecular mechanics MPro network network analysis Novel coronavirus nucleocapsid outbreak performed plant plants procyanidin procyanidin. Protein receptors Replication SARS-CoV-2 screened Spike protein Spike proteins surface area text text mining the SARS-CoV-2 therapeutic trimeric van der Waal Van der Waals van der Waals interactions virus [DOI] 10.1080/07391102.2020.1823887 PMC 바로가기 [Article Type] Article
The chemical constituents of Sterculia comosa (wall) Roxb woods for arginase inhibitory, antioxidant activity, and molecular docking against SARS CoV-2 proteinResearch Article Published on 2022-01-192022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] Sterculia comosa (wall) Roxb. antioxidant arginase binding affinity docking DPPH flavonoid inhibitory inhibitory activity Interaction isolate methanol molecular docking Nsp12 PLPro predicted Protein SARS CoV-2 scavenging spike was determined [DOI] 10.1016/j.heliyon.2022.e08798 PMC 바로가기 [Article Type] Research Article
New chalcone derivatives as effective against SARS-CoV-2 agentSARS-CoV-2 제제에 효과적인 새로운 칼콘 유도체Article Published on 2021-12-012022-09-11 Journal: International journal of clinical practice [Category] SARS, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADME Analysis Angelica antiviral activities antiviral activity antiviral drug binding affinity carried chalcone Compound compounds Concentration coronavirus Cycling derivative Determination dose drug candidates drugs effective eight facilitate flavonoid flavonoids identify inhibit inhibiting inhibitor New protease Proteases quercetin RNA polymerase RNA-dependent RNA polymerase RT-PCR SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus targets threshold Viral RNA viral RNA-dependent RNA polymerase Virtual screening [DOI] 10.1111/ijcp.14846 PMC 바로가기 [Article Type] Article
Nanotechnology Applications of Flavonoids for Viral DiseasesReview Published on 2021-11-082022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] Anti-viral anti-viral agent application approved Bioavailability caused Compound coronavirus 2 Coronaviruses COVID-19 disease drug delivery Ebola effective effective drug flavonoid flavonoids flu include increasingly MERS Middle East Nanotechnology Nipah virus Other pandemic plants Prophylactic recent reported respiratory resulting SARS-CoV-2 Side effect therapeutic agent Vaccine viral disease Viral diseases virus viruses Zika zoonotic disease [DOI] 10.3390/pharmaceutics13111895 PMC 바로가기 [Article Type] Review
Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive ReviewReview Published on 2021-10-292022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acetylcholinesterase activity assessment bioactivities Biological biological properties Buddleja Central nervous system Characteristics characterized chemotaxonomy Cirsium CNS compounds Comprehensive derivatives dietary supplement disorders drug candidates Effect exhibited flavonoid flavonoids Health indicated inhibitory activity linarin Osteoarthritis Osteoporosis pharmacological phytochemistry Potential proliferation review therapeutic [DOI] 10.3390/ph14111104 PMC 바로가기 [Article Type] Review
Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2Article Published on 2021-10-292022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] Anastatica hierochuntica Citrus reticulate in vitro screening Kickxia aegyptiaca aglycone Analysis Anastatica candidate carried Citrus co-crystallized Combination Compound drug Effects evaluated examined flavonoid flavonoid aglycones highest hydrolyzed identify in vitro in vivo inflammatory disease inhibitor metabolite methanol molecular docking Molecular docking study MPro Naturally Potential reference standard SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro Structure therapeutic potential these compound virus inhibition [DOI] 10.3390/molecules26216559 PMC 바로가기 [Article Type] Article
Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic ReviewSARS-CoV-2 표적에 대한 천연 플라보노이드의 유망한 항바이러스 활성: 체계적인 검토Review Published on 2021-10-142022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료법, 치료제, [키워드] 3CLpro activities activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Analysis baicalein baicalin caused Clinical studies clinical study Combination coronavirus COVID-19 pandemic derivatives drug Effect EGCG flavonoid flavonoids focus Immunity in silico in vitro In vitro studies in vitro study in vivo investigated lack less MERS MERS-CoV Mutation myricetin natural nucleocapsid protease public health quercetin respiratory review SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus silico studies strain synthetic drugs tannic acid target targets the disease therapeutic intervention therapeutic potential Vaccines viruses [DOI] 10.3390/ijms222011069 PMC 바로가기 [Article Type] Review
Natural Polyphenols Inhibit the Dimerization of the SARS-CoV-2 Main Protease: The Case of Fortunellin and Its Structural Analogs천연 폴리페놀은 SARS-CoV-2 주요 프로테아제의 이량체화를 억제합니다: Fortunellin 및 그 구조적 유사체의 사례Article Published on 2021-10-072022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] cleave computational method COVID-19 dietary supplement dietary supplements drug candidate drug candidates flavonoid glycoside homodimer identify in vitro inhibiting inhibitor Metadynamics molecular simulations MPro natural natural products polyphenol polyprotein protease Protein Replication reported SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 protein SARS-CoV-2 proteins the SARS-CoV-2 Therapeutics transcript Viral viral growth [DOI] 10.3390/molecules26196068 PMC 바로가기 [Article Type] Article
Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives안티 코로나 바이러스 및 면역 조절 페놀 화합물 : 기회 및 약물 치료 적 관점Review Published on 2021-08-232022-09-01 Journal: Biomolecules [Category] 진단, 치료제, [키워드] acute respiratory syndrome coronavirus antiviral drug antiviral drugs applicability cardiovascular caused chalcone Comorbidities COVID-19 COVID-19 patients diabetes disease dual dysregulated immune response dysregulated immune responses effective flavonoid high mortality rate immune response immune responses immunomodulatory activities kidney Kidney diseases MERS-CoV Middle East Respiratory Syndrome Virus modulation natural phenolic compound natural phenolic compounds natural products Novel coronavirus opportunity patients with comorbidity Perspective pharmacological Pharmacotherapeutic plants respiratory Respiratory disease SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe respiratory disease shown systemic inflammation therapeutic strategy viruses [DOI] 10.3390/biom11081254 PMC 바로가기 [Article Type] Review
Flavonoid compounds of buah merah ( Pandanus conoideus Lamk) as a potent SARS-CoV-2 main protease inhibitor: in silico approachResearch Published on 2021-08-102022-10-31 Journal: Future Journal of Pharmaceutical Sciences [Category] COVID-19, [키워드] absorbed anti-SARS-CoV-2 Anti-SARS-CoV-2 Agents antiparasitic Antiviral antiviral drug AutoDock binding affinity can be used Candidates carotenoid carried complex complexes Compound COVID-19 COVID19 determine docking result effective examined flavonoid fraction global pandemic in silico Approach Indonesia ingredient inhibitor Interaction Ligand metabolite Pandanus conoideus PDB ID pharmacokinetic protease quercetin Quercetin 3-O-glucose Quercetin 3′-glucoside receptor Result SARS-CoV-2 main protease stability Taxifolin 3-O-α-arabinopyranose the SARS-CoV-2 Toxicity [DOI] 10.1186/s43094-021-00309-0 PMC 바로가기 [Article Type] Research