Predictors of impaired SARS-CoV-2 immunity in healthcare workers after vaccination with BNT162b2BNT162b2 백신 접종 후 의료 종사자의 SARS-CoV-2 면역 장애 예측자Article Published on 2022-04-142022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody Antibody titers BNT162b2 CD4 CD8 Cellular immune response cellular immune responses cellular immunity comparable Concentration convalescent detectable did not produce effective frequencies Frequency healthcare healthcare worker Healthcare workers hospital humoral humoral immune response IgG immune response immune responses Immunosuppression increased risk individual infection with SARS-CoV-2 median organ pandemic post vaccination PROTECT recipients reduced required Responder risk factor Risk factors SARS-CoV-2 SARS-CoV-2 immunity seroconversion rate significantly higher solid organ spike IgG Standard of care subject T cell T cell response T cell responses vaccination Vaccine was measured yielding [DOI] 10.1038/s41598-022-10307-8 PMC 바로가기 [Article Type] Article
An evaluation of childhood tuberculosis program in Chegutu District, Zimbabwe, 2020: a descriptive cross-sectional study2020년 짐바브웨 Chegutu 지역의 아동 결핵 프로그램 평가: 기술 횡단면 연구Article Published on 2022-04-142022-09-11 Journal: BMC health services research [Category] 치료제, [키워드] Analysis analyzed childhood Childhood tuberculosis children conducted Contact tracing contributing to COVID-19 cross-sectional cross-sectional study detection rate District Epi ethambutol evaluated females frequencies functional Fund funds generate global public health Health health facilities health information Health information system health worker Information System knowledge lack Likert scale lockdown lockdown restrictions majority management means Measures mentorship morbidity and mortality motor vehicle National notification Nurse Nurses opportunity participated Program Program evaluation proportion proportions questionnaire reason resources stock supervision Support System Tablet target threat Tuberculosis was used were used X-ray Zimbabwe [DOI] 10.1186/s12913-022-07918-2 PMC 바로가기 [Article Type] Article
CHARM: COVID-19 Health Action Response for Marines-Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 testCHARM: qPCR SARS-CoV-2 테스트 양성 후 무증상 및 증상 감염에 대한 항원 특이적 인터페론-감마 및 IL2 반응의 해병을 위한 COVID-19 건강 조치 대응Article Published on 2022-04-072022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] Action All participants Asymptomatic Asymptomatic cases Cell mediated immunity class correlated COVID-19 COVID-19 symptoms COVID-19 vaccine COVID-19 vaccines dropped enrolled Enrollment epitope Epitopes Follow-up frequencies Frequency IFN-γ IFN-γ response IFN-γ responses IL2 immune response include Infection membrane N and M N and S proteins N protein nucleocapsid occurred participant Participants peaked peptide peptide pool peptides positive Post-infection predicted Protein Proteins qPCR qPCR test Responder response responses S proteins S, N and M proteins SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 test significantly Study participants subjects Support symptomatic symptomatic and asymptomatic symptomatic infection symptomatic participants T cell T cell response T cell responses tested the N protein These data were measured with COVID-19 [DOI] 10.1371/journal.pone.0266691 PMC 바로가기 [Article Type] Article
Trend clustering from COVID-19 tweets using graphical lasso-guided iterative principal component analysis그래픽 올가미 기반 반복 주성분 분석을 사용한 COVID-19 트윗의 추세 클러스터링Article Published on 2022-04-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Accuracy addition Care caused changes in Characteristics Cluster Clustering conducted coronavirus disease correlation COVID-19 determine difficulty Emergency event experiment frequencies Frequency help International iterative Japanese Medical care overcome parameter past Pneumonia Principal component principal component analysis Quantitative state of emergency summer Tokyo trend Worry [DOI] 10.1038/s41598-022-09651-6 PMC 바로가기 [Article Type] Article
Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients항CD20 치료 다발성 경화증 환자에서 1차부터 3차까지의 SARS-CoV-2 mRNA 백신 접종에서 체액성 면역 반응이 지속적으로 감소하고 세포 면역 반응이 지속됨Article Published on 2022-04-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] Abbott Abbott Laboratories administration All participant All participants allowance anti-CD20 anti-CD20 therapy Antibody Response B cell BNT162b2 BNT162b2 mRNA Booster vaccine CD20 CD4 CD8 Cellular immune response cellular response Cohort dropped frequencies Frequency humoral include longitudinal study median monoclonal antibodies mRNA vaccination mRNA vaccine Multiple multiple sclerosis no difference Ocrelizumab participant Patient PBMC peptide peptide pool Prophylactic reactive reduced reduction SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG II Quant assay SARS-CoV-2 vaccination second vaccination seropositive Seropositivity Spike-specific T-cell responses Study design sustained T-cell T-cell Response T-cell responses T-cells T-lymphocyte treated vaccination was done were assessed were measured [DOI] 10.1016/j.msard.2022.103729 PMC 바로가기 [Article Type] Article
Comparative analysis of alignment-free genome clustering and whole genome alignment-based phylogenomic relationship of coronavirusesResearch Article Published on 2022-03-082022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] addition antiviral drug approach cause caused Characteristics Cluster Clustering Combination Comparative analysis coronavirus coronavirus genome demonstrated disease Evolution explained frequencies Genome Host Human humans information interspecific less MERS-CoV molecular pathogenicity Phylogenetic Phylogenetic relationship Phylogenetic tree Research robust SARS-CoV SARS-CoV-2 selected severe respiratory syndrome Vaccines virus whole genome zoonotic origin [DOI] 10.1371/journal.pone.0264640 PMC 바로가기 [Article Type] Research Article
The Association Between Men’s Mental Health During COVID-19 and Deterioration in Economic StatusCOVID-19 기간 동안 남성의 정신 건강과 경제 상태 악화의 연관성Article Published on 2022-03-012022-09-11 Journal: American journal of men's health [Category] SARS, 치료기술, [키워드] Adjustment disorder affected Anxiety association changes in complex COVID-19 COVID-19 crisis COVID-19 outbreak COVID-19 pandemic demographic variable Demographic variables deteriorate Deterioration disorder distress economic change economic status emotional emotional eating frequencies Gender greater group high risk identify impacted impairment indicated individual investigated measure men men’s mental health Mental mental health participant Psychological distress question questionnaire reported Result significantly status Stress symptoms of depression turn women [DOI] 10.1177/15579883221082427 PMC 바로가기 [Article Type] Article
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individualsNK 세포 빈도, 기능 및 BNT162b2 mRNA 항 SARS-CoV-2 예방 접종을 받은 건강하고 면역이 약한 개인에서 백신 결과와 상관 관계Research Article Published on 2022-02-082022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive immune responses anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 mRNA vaccine Cancer characterized clinical material clinical trial Course COVID-19 Day description Effect EudraCT frequencies Frequency healthy healthy individuals immune cells immune response immune responses Immunocompromised immunocompromised individual Immunocompromised patient Immunocompromised patients in healthy individual Innate immune cells Innate immunity mRNA mRNA vaccination mRNA vaccine mRNA-based NK cell NK cells NKG2C non-randomized Open-label outcome Peripheral blood Phenotypes positive correlation preserved Prospective clinical trial Registered Result SARS-CoV-2 supplementary material Trial registration vaccination Vaccine vaccine trial viral infections [DOI] 10.1186/s10020-022-00443-2 PMC 바로가기 [Article Type] Research Article
Children and Adults With Mild COVID-19: Dynamics of the Memory T Cell Response up to 10 Months경증 COVID-19가 있는 어린이 및 성인: 최대 10개월까지 기억 T 세포 반응의 역동성Clinical Trial Published on 2022-02-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 치료기술, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immunity Adults Analysis Antibody Response Antigen CD4 Cell cellular children Concentration concentrations contribute controls Coronavirus-2 correlated Course COVID-19 Cytokines detectable determine develop Dynamics effective effector memory ELISPOT exposure to frequencies heat heat-inactivated IFN-γ IFN-γ ELISPOT IgG immune memory infected children infections Longitudinal assessment marker memory T memory T cell Mild mild SARS-CoV-2 infection mild symptoms Mild-to-moderate moderate moderate symptoms Month Nucleocapsid proteins overlapping PBMC PBMCs peptide peptides performed Peripheral blood peripheral blood samples recall reduced Reinfection respiratory response Result SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells serum antibody severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly Stimulation symptom onset Symptoms T cell T cell immunity T cell response T cells Th1 phenotype [DOI] 10.3389/fimmu.2022.817876 PMC 바로가기 [Article Type] Clinical Trial
Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구Article Published on 2022-02-012022-09-11 Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used [DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article