Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity다중체 분석은 COVID-19 중증도의 세포 유형별 분자 결정 요인을 나타냅니다.Article Published on 2022-08-172022-10-30 Journal: Cell Systems [Category] COVID-19, MERS, 바이오마커, 변종, 유전자 메커니즘, [키워드] Analysis CD56 Cell cell types COVID-19 COVID-19 severity cytokine determinant determinants dysfunction enrichment functions gene discovery Genes Genetic genetic risk Genetic variation genome-wide association Genome-wide association study genomic GWAS healthy human lung innate immune response Intervention limit machine learning mendelian randomization molecular natural killer network analysis NK cell NK cells NK-cell Pathogenesis potential therapeutic targets provide rare variant analysis reveal risk severe COVID-19 severe disease single-cell single-cell multiomic profiling. Support T cells these cell These cells upstream variant [DOI] 10.1016/j.cels.2022.05.007 PMC 바로가기 [Article Type] Article
Efficacy of care manager-led support for family caregivers of people with dementia during the COVID-19 pandemic: a randomized controlled studyRandomized Controlled Trial Published on 2022-08-152022-10-05 Journal: BMC Geriatrics [Category] 임상, [키워드] analyzed baseline burden Care Care burden Caregiver changes in cognitive collected conducted control group COVID-19 COVID-19 infection COVID-19 pandemic decrease Dementia Deterioration Effect Efficacy ENhance enrolled evaluated exacerbate examined family fear functions groups IMPROVE Infection infection control Infection control measure Infection prevention information Intervention intervention group interview measure Modification Multiple Older pandemic participant PHQ-9 physical preparedness Primary outcome Psychological outcome randomized controlled study Randomized controlled trial randomly divided Registered regression analysis risk of infection Saliva salivary scale secondary outcome secure Spread Support usual care was measured [DOI] 10.1186/s12877-022-03371-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like proteaseSARS-CoV-2 파파인 유사 프로테아제의 알로스테릭 부위에서 복합체 내 천연 페놀 화합물의 항바이러스 활성Article Published on 2022-08-112022-09-11 Journal: Communications Biology [Category] SARS, 변종, 신약개발, 치료제, [키워드] antiviral activity antiviral immune response cleavage complex Compound Concentration coronavirus COVID-19 infections cysteine Cytopathic effect down-regulated functions Host immune responses inhibited innate immune responses ISG15 molecular interaction Mutation natural phenolic compound Papain Papain-like protease PLPro protease Protein SARS-CoV-2 Support ubiquitin variants of SARS-CoV-2 Vero Cell Vital function X-ray [DOI] 10.1038/s42003-022-03737-7 PMC 바로가기 [Article Type] Article
Roles and functions of SARS-CoV-2 proteins in host immune evasion숙주 면역 회피에서 SARS-CoV-2 단백질의 역할과 기능Review Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] accessory protein accessory proteins activator acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus described ENCODE evade Frame function functions Genome Host host immune system IFN-β IFNs immune immune evasion inhibiting interferon interferons IRF3 mechanism mechanisms NF-κB nine non-structural protein non-structural proteins nsp1 Nsp12 nsp13 nsp14 Nsp15 nsp5 NSP6 NSP8 Nsps nuclear nuclear translocation Open reading frame ORF10 ORF3b ORF6 ORF8 Orf9b Perspective Phosphorylation Protein Regulatory role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT2 STATs structural proteins suppress TBK1 Transcription type I type I and III interferons variety Viral protein Viral proteins [DOI] 10.3389/fimmu.2022.940756 PMC 바로가기 [Article Type] Review
Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?정신 장애의 후각 장애: 비염이 질병 정신 생리학에 영향을 줍니까?Review Published on 2022-08-052022-09-11 Journal: Translational Psychiatry [Category] 유전자 메커니즘, [키워드] adverse effect Brain brain development cause Clinical studies clinical study contribute coronavirus disease Coronavirus disease 2019 COVID-19 Critical Depression disease environmental factor environmental factors Evidence followed by functions illness impairment Inflammation involved long-lasting Mental nasal Neuropsychiatric olfactory olfactory dysfunction olfactory function outbreak outcome pathophysiological mechanism pathophysiological mechanisms pathophysiology produced Psychiatric Psychiatric disorders Psychopathology recent Regulation Research respiratory viral infection respiratory viral infections risk Schizophrenia [DOI] 10.1038/s41398-022-02081-y PMC 바로가기 [Article Type] Review
The Neutrophil-to-Lymphocyte Ratio and the Platelet-to-Lymphocyte Ratio as Predictors of Mortality in Older Adults Hospitalized with COVID-19 in Peru페루에서 COVID-19로 입원한 노인의 사망률 예측 인자로서의 호중구 대 림프구 비율 및 혈소판 대 림프구 비율Article Published on 2022-08-032022-09-11 Journal: Disease Markers [Category] 바이오마커, [키워드] 95% CI 95% confidence interval adjusted Adults age Analysis analyzed association AUC AUC-ROC value carried causes Comorbidities confidence interval COVID-19 Cox regression analysis Cox regression model cut-off cut-off point described evaluated Follow-up functions greater hazard ratio high risk higher risk hospital Hospital mortality Hospital stay Hospitalized in-hospital mortality interquartile interquartile range Laboratory logarithmic transformation male marker median age Mortality mortality rate neutrophil NLR Older older adult Older adults outcome patients with COVID-19 performed Platelet predictor Prognostic markers Prognostic value Ratio reported retrospective cohort ROC ROC Curve selected Sociodemographic Treatment variables with COVID-19 [DOI] 10.1155/2022/2497202 PMC 바로가기 [Article Type] Article
Conjugation with 8-arm PEG and CRM 197 enhances the immunogenicity of SARS-CoV-2 ORF8 protein8-arm PEG 및 CRM 197과의 접합은 SARS-CoV-2 ORF8 단백질의 면역원성을 향상시킵니다Article Published on 2022-08-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] activate adjuvant adjuvants aluminum antigens BALB/c mice carrier protein cellular conjugate Conjugates conjugation COVID-19 pandemic CRM(197) cytokine Cytokines effective effective vaccine Effective vaccines Effectiveness eight-arm PEG. ENhance evaluated expected functions humoral immune response IFN-β IFN-γ IgG IL-5 immune protection immune response immune responses immunogenicity IMPROVE inherent inhibit liver multiple antigen ORF8 ORF8 protein proliferation promoter Protein raise renal SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine SARS-CoV-2 variants splenocyte T helper cell T helper cells the SARS-CoV-2 TNF-α Toxicity Vaccine Vaccines variant [DOI] 10.1016/j.intimp.2022.108922 PMC 바로가기 [Article Type] Article
Telomere G-triplex lights up Thioflavin T for RNA detection: new wine in an old bottle텔로미어 G-트리플렉스, RNA 검출을 위한 티오플라빈 T 조명: 오래된 병에 담긴 새 와인Article Published on 2022-08-012022-09-11 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] applied biosensor develop feature function functions G-quadruplex G-triplex generate Human Label-free detection molecular N-gene platform promote RNA RNA detection RNA sequence sensitivity target Target recycling telomere the SARS-CoV-2 Thioflavin Thioflavin T. triplex was selected [DOI] 10.1007/s00216-022-04180-7 PMC 바로가기 [Article Type] Article
Heterogeneity in IgG-CD16 signaling in infectious disease outcomesArticle Published on 2022-08-012022-11-15 Journal: Immunological reviews [Category] 진단, [키워드] acute infections allele binding contribute coronavirus disease COVID-19 dengue disease disease downstream driven by effector functions. expression Fc afucosylation form functions glycosylation heterogeneity IgG IgG antibody IgG1 IgG1 antibodies immune complex Immune homeostasis Infection Infectious disease Inflammation Inflammatory response inflammatory signaling ligands mechanism modulate outcome Pathogenesis pathogenic required Signaling viral infection while [DOI] 10.1111/imr.13109 PMC 바로가기
SARS-CoV-2 epitope-specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durabilityCOVID-19 질병 중증도 및 항체 내구성 전반에 걸친 SARS-CoV-2 에피토프 특이적 CD4 + 기억 T 세포 반응Article Published on 2022-07-222022-09-11 Journal: Science Immunology [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive anti-S antibody antibody Antibody Response Antibody responses Boston CD4 Cell cells circulating conducted controls convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity demonstrated disease disease control disease course early disease epitope Epitopes First wave follicular function functions greater histocompatibility complex Hospitalization Immunity individual longitudinal study major histocompatibility complex memory memory T nucleocapsid pandemic peptide Population predict proportion recognizing response SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted severe acute respiratory syndrome Coronavirus subset sustained T cell T cells T cells response T helper USA viral clearance virus [DOI] 10.1126/sciimmunol.abl9464 PMC 바로가기 [Article Type] Article