Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale Research Published on 2022-07-182022-10-05 Journal: Nature biotechnology [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] approach complementary complex country de novo delta variant elevated epidemiological Epidemiology genetic diversity National predict public health quantification representing Reproduction number reproductive robust SARS-CoV-2 SARS-CoV-2 surveillance sequenced Sequencing spatiotemporal Support Surveillance variant variants of concern [DOI] 10.1038/s41587-022-01387-y [Article Type] Research
SARS-CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study중증 COVID-19 환자에서 SARS-CoV-2 게놈 특성 및 SARS-CoV-2 바이러스 다양성의 임상 영향: 전향적 다기관 코호트 연구Observational Study Published on 2022-07-132022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] Acute respiratory failure association clinical clinical outcomes COPD COVID-19 COVIDSeq Diversity Endpoint genetic diversity groups had more higher risk hospital ICU admission ICUs Ill Illumina Impact intensive care intensive care unit Mortality multicenter Next-generation sequencing not differ Observational cohort study Older other variant other variants Paris Patient Prospective Respiratory failure SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants sequenced severe COVID-19 significantly SOFA score SOFA scores specific mutations Spread suggested the patient variant Variant of concern. variants were infected [DOI] 10.3390/v14071529 PMC 바로가기 [Article Type] Observational Study
Analysis of the docking property of host variants of hACE2 for SARS-CoV-2 in a large cohort대규모 코호트에서 SARS-CoV-2에 대한 hACE2의 숙주 변이체의 도킹 특성 분석Article Published on 2022-07-112022-09-11 Journal: PLoS Computational Biology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin binding free energy caused coronavirus coronavirus disease COVID-19 COVID-19 infection Diagnosis docking free energy genetic diversity genomic data global health hACE2 Health Host human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human cells individual individuals Interaction large cohort missense variant Mobility molecular molecular dynamics Molecular dynamics simulation molecular interaction Novel coronavirus novel coronavirus disease outbreak physical provided receptor SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infections selected severe acute respiratory syndrome Coronavirus Spike protein subject the spike protein UK biobank variant [DOI] 10.1371/journal.pcbi.1009834 PMC 바로가기 [Article Type] Article
Whole-genome analysis and mutation pattern of SARS-CoV-2 during first and second wave outbreak in Gwangju, Republic of Korea대한민국 광주에서 1차 및 2차 유행 중 SARS-CoV-2의 전체 게놈 분석 및 돌연변이 패턴Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis analyzed Cell culture circulating clade clinical clinical samples collected conducted Culture Deletion deletions determine dominant feature genetic diversity genomic genomic alteration high viral load in-depth analysis indicate Missense mutated Mutation Next-generation sequencing nucleic acid Nucleic acid purification outbreak Pathogenesis pathogenesis of SARS-CoV-2 Patient phylogenetic analyses Phylogenetic analysis phylogenetic analysis Point mutation Proteins Region regions Research SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolates SARS-CoV-2 pathogenesis second wave significant difference South Korea statistical analysis therapeutic Viral load was performed whole genome [DOI] 10.1038/s41598-022-14989-y PMC 바로가기 [Article Type] Article
Genetic Analysis of HPIV3 That Emerged during the SARS-CoV-2 Pandemic in Gwangju, South Korea한국 광주에서 SARS-CoV-2 전염병 동안 출현한 HPIV3의 유전자 분석Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] analysis antigenic Biotechnology caused center Characteristics coding region Collapsing Community continuous monitoring COVID-19 COVID-19 pandemic decrease exhibiting gene sequence Genetic genetic diversity hemagglutinin homology human parainfluenza virus human parainfluenza virus type 3 Immunity India inflow Japan Lineage mass measure neuraminidase Occurrence outbreak pandemic pathogen Pathogens peaked performed Prevalence prevalent reduced Region reported respiratory viral respiratory viruses restriction sequence South Korea Spread strain Strains Surveillance surveillance. the SARS-CoV-2 virus [DOI] 10.3390/v14071446 PMC 바로가기 [Article Type] Article
Epidemiological and virological surveillance of influenza viruses in China during 2020-20212020-2021년 동안 중국에서 인플루엔자 바이러스의 역학 및 바이러스 감시Article Published on 2022-06-292022-09-11 Journal: Infectious Diseases of Poverty [Category] COVID19(2023년), SARS, 치료제, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition analyses Analysis analyzed antigenic antigenic diversity Antiviral antiviral medication Antiviral medications B/Victoria lineage viruses caused Characteristics characterized China Chinese circulating collected component components conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic declined Diversity Epidemic epidemiological Epidemiology flu Genetic genetic diversity Hemisphere hospital Influenza influenza like illness influenza virus Influenza virus influenza viruses inhibitors isolate Laboratory Lineage mainland molecular Mutation network neuraminidase inhibitor neuraminidase inhibitors Next-generation sequencing outbreak pandemic phenotypic Phylogenetic analysis preventive measure preventive measures reduced Region remained representing respiratory respiratory specimens respond SARS-CoV-2 Seasonal influenza sensitivity Sequencing severe acute respiratory syndrome Coronavirus specimen study period Surveillance susceptibility tested the vaccine unique Virological Virological. virus virus viruses was performed was used Winter [DOI] 10.1186/s40249-022-01002-x PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other LineagesCOVID-19 환자의 비인두 샘플에서 SARS-CoV-2 분석은 다른 계통과 관련하여 우려되는 변이체의 성장 특성을 배치하여 인구 변이 및 다양한 표현형을 보여줍니다Article Published on 2022-06-292022-09-11 Journal: mSphere [Category] COVID19(2023년), SARS, 변종, [키워드] A549 cells Alpha amplified Beta Beta variant Biology biology of SARS-CoV-2 causative agent Cell Cell culture cell line cells change characterized clinical isolates clinical samples concern Context coronavirus COVID-19 Delta disease effective Evolution genetic diversity genetics genome sequence genomic global pandemic growth growth kinetics hACE2 hospitalized patient hospitalized patients humans immune evasion increased risk indicated Infection isolate isolates less Lineage minor minor genomic variants morbidity Mortality Nasopharyngeal swab nasopharyngeal swabs New no difference not different omicron Other other coronaviruses other variant other variants pandemic patients pattern planet Population Population dynamics Population genetics Postinfection preserved property Research RNA RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence several variants Spread suggested Transmission vaccination Vaccine Variability variant variants variants of concern variants of SARS-CoV-2 variants. Variation Vero E6 Vero E6 cell VERO E6 cells virus Virus evolution VoC VOCs widespread with COVID-19 [DOI] 10.1128/msphere.00913-21 PMC 바로가기 [Article Type] Article
Epidemiology and Genomic Characterization of Two Novel SARS-Related Coronaviruses in Horseshoe Bats from Guangdong, ChinaArticle Published on 2022-06-282023-07-08 Journal: mBio [Category] COVID19(2023년), [키워드] Epidemiology genetic diversity horseshoe bats. SARS-related coronavirus [DOI] 10.1128/mbio.00463-22 PMC 바로가기
Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan우즈베키스탄의 임상 샘플에서 얻은 SARS-CoV-2의 게놈 서열 다양성Article Published on 2022-06-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha Amino acid amino acid substitution annotation association change clade clades clinical isolates clinical sample Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity D614G Deleterious Deletion Delta Denmark disease severity evidenced Evolution female followed by genetic diversity Genome Genomic analysis genomic change Genotype help Identified isolate isolates male Missense Missense mutation Missense mutations Mutation Nextstrain NSP Nsp12 nsp13 Nsp3 nsp4 NSP6 nucleotide Open reading frame ORF ORF7a Pathogenesis PCR-positive patient Protein reading regions Research Russia SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severity significantly SNP SNPs subclade Substitution synonymous Tashkent the Spike two group two groups USA variant variants Variation WGS whole genome sequence with COVID-19 [DOI] 10.1371/journal.pone.0270314 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City뉴욕시에서 알파 및 엡실론 변이체로 중복 감염 중 SARS-CoV-2 숙주 내 재조합 검출Article Published on 2022-06-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] allele Alpha Alpha variant B.1.1.7 B.1.429 classic coding regions Coronavirus replication detection Diversity Epsilon feasible full genome sequencing functions generate genetic diversity Genome genome sequence genomes Haplotype Host identify independent individual infect New York City nucleocapsid Occurrence ORF pathogen Pathogens Recombination reveal S gene SARS-CoV-2 superinfection Support variant virus [DOI] 10.1038/s41467-022-31247-x PMC 바로가기 [Article Type] Article