Epidemiology of the First Wave of COVID-19 ICU Admissions in South Wales—The Interplay Between Ethnicity and DeprivationMedicine Published on 2020-10-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] admitted to ICU age Asian Asthma Bame Community Comorbidity complex COVID-19 COVID-19 admission death Deprivation diabete Epidemiology Ethnicity Factor genetic polymorphisms geographical area hospital ICU ICU admission IQR male median Mortality mortality rate obesity Patient patient with COVID-19 patients with COVID-19 peaked Prevalence proportion recorded representing Risk factors South turn Wave [DOI] 10.3389/fmed.2020.569714 PMC 바로가기 [Article Type] Medicine
Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population AnalysisSARS-CoV-2와 잠재적으로 관련된 숙주 유전 변이: 다중 집단 분석Genetics Published on 2020-10-022022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect African AHSG alleles allelic Analysis Asian association average calculate caused CCL2 CCL5 CD209 clinical collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease distribution EAS eQTLs European Europeans expression expression data expression quantitative trait loci Frequency furin genetic determinant genetic determinants Genetic polymorphism genetic polymorphisms genetic variants genetics Genome GWAS highlight host genetics ICAM3 identify IFN IL4 inter-individual list loci lowest modulate Multiple nucleotide outcome outcomes Population genetics populations predict promoter Quantitative respiratory Result risk risk allele SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility sequence sequences severe acute respiratory syndrome Coronavirus severity significantly significantly lower Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility TMPRSS2 variant viruses were used [DOI] 10.3389/fgene.2020.578523 PMC 바로가기 [Article Type] Genetics
4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor4,4′-다이아미노디페닐 설폰(DDS) 염증소체 경쟁자로서Article Published on 2020-08-192022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, 한센병, [키워드] 4,4′-diaminodiphenyl sulfone (dapsone) Activation AD Alter Alzheimer’s disease Alzheimer’s disease Antibiotics binding caspase-1 cause cleaved Cognitive impairment Combination DDS demonstrated diagnosed Diseases effective Effects Factor Fever fibrosis genetic polymorphisms Hansen’s disease human disease immune response implicated Inflammasome inflammasomes intracellular domain involved Korean lepromatous leprosy (also known as Hansen’s disease) leprosy ligands LL Lung inflammation MADDS mechanism microbial Mild molecular monoacetyldapsone MPO Mutation myeloperoxidase NACHT, LRR and PYD domains-containing protein 3 NLRP3 NLRP3 inflammasome Parkinson’s disease Patient protein 3 receptor Regulation reported responsible S protein SARS-CoV SARS-CoV-2 Sulfone susceptibility tested TLR TLR2 TLRs Toll-like receptor treated Treatment type 2 diabetes variety viruses zoonotic [DOI] 10.3390/ijms21175953 PMC 바로가기 [Article Type] Article
The Enigma of Low COVID-19 Fatality Rate in India인도의 낮은 COVID-19 치사율의 수수께끼Genetics Published on 2020-07-282022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] ACE2 receptors acute respiratory syndrome coronavirus Alter angiotensin converting enzyme 2 average BCG vaccination Betacoronavirus caused circulating city coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 death environmental factor environmental factors Epigenetic evidenced Factor Factors Fatality rate genetic diversity Genetic polymorphism genetic polymorphisms Guangdong Health Organization high temperature Host Humidity hypothese ICU admission immune responses include India Indian population Innate immunity killer cell immunoglobulin-like receptors less lowest mechanical ventilation micro RNA microRNA Mutation offer pandemic pathogen Perspective Pneumonia Rate reducing reported respiratory responsible SARS-CoV-2 SARS-CoV-2 strains severity strain susceptibility the disease Transmissibility Transmission viability virulence virus WHO World Health Organization Wuhan [DOI] 10.3389/fgene.2020.00854 PMC 바로가기 [Article Type] Genetics
Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine StormReview Published on 2020-07-182022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] ACE ACE-2 ACE-2R acute respiratory distress Affect Angiotensin converting enzyme-2 Antiviral baseline bind cause Cell chronic inflammatory disease common cold coronavirus COVID-19 current CYP2D6 cytochrome P450 cytokine level Cytokine storm Cytokines disease Ebola Enzymes Genetic polymorphism genetic polymorphisms global pandemic HIV HO-1 Human immunodeficiency virus include Inflammatory response kidney Lungs majority manifested medication MERS Middle East mitochondrial dysfunction organ P450 patients with obesity porphyrins reactive oxygen specy receptor reservoir resulting RNA virus role SARS-CoV-2 Spread storm subsequent syndrome systemic inflammatory response therapy Treatment upregulation virus white adipose tissue [DOI] 10.3390/antiox9070636 PMC 바로가기 [Article Type] Review
Occult hepatitis B virus infection predicts non-alcoholic steatohepatitis in severely obese individuals from ItalyArticle Published on 2020-07-012023-06-13 Journal: Liver international : official journal of the Inte [Category] B형 간염, [키워드] diabetes genetic polymorphisms non-alcoholic fatty liver obesity occult HBV infection [DOI] 10.1111/liv.14473
Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti엑솜 전체의 연관성 연구는 이집트숲모기(Aedes aegypti)에서 뎅기열 바이러스 유형 1 및 3에 대한 특이적 내성을 기본으로 하는 크게 구별되는 유전자 세트를 보여줍니다Research Article Published on 2020-05-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Aede allelic variant allelic variants association ATP average binding activity compatibility Dengue dengue virus DENV-1 DENV-3 Exome exomes exposure to Frequency Gabon Genes Genetic genetic architecture genetic marker Genetic polymorphism genetic polymorphisms Genetic variation Genome group Host host gene host genes host-pathogen interactions hosts identify indicate Infection Interaction invertebrate invertebrates investigated involved mechanism Mosquito natural population p values pathogen pathogen genotype pathogen-specific Pathogens phenotype phenotypic polymorphism Region reveal sequenced significantly single-nucleotide single-nucleotide polymorphism SNP specific resistance specificity statistical strain Strains sulfur susceptible the mosquito transmembrane variant Variation with infection Zinc zinc ion [DOI] 10.1371/journal.pgen.1008794 PMC 바로가기 [Article Type] Research Article
IL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazilarticle Published on 2019-03-312024-09-01 Journal: Annals of Human Genetics [Category] 한센병, [키워드] genetic polymorphisms interleukin-17 interleukin-8 leprosy reactional episodes [Article Type] article
Relative indoleamine 2,3-dioxygenase transcript level concerning anti-HBs titers in response to HBV vaccination in hemodialysis patientsArticle Published on 2018-10-012023-06-18 Journal: Expert review of vaccines [Category] B형 간염, [키워드] 3-dioxygenase Anti-HBs antibodies genetic polymorphisms Hemodialysis Indoleamine 2 transcript. [DOI] 10.1080/14760584.2018.1527691
Genome-wide association study identifies HLA-DR variants conferring risk of HBV-related acute-on-chronic liver failureComparative Study Published on 2018-04-012023-06-19 Journal: Gut [Category] B형 간염, [키워드] genetic polymorphisms hepatitis B HLA liver failure [DOI] 10.1136/gutjnl-2016-313035 [Article Type] Comparative Study