Can machines learn the mutation signatures of SARS-CoV-2 and enable viral-genotype guided predictive prognosis?기계가 SARS-CoV-2의 돌연변이 신호를 학습하고 바이러스 유전자형 유도 예측 예후를 가능하게 할 수 있습니까?Article Published on 2022-08-152022-09-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] accumulation added Additive age approach Can caution changes in clade cleaning Continuous driving epitope Epitopes Factor Features Genome genomes genomic data Genotype genotypic global healthcare hallmark HLA Implications Infection information Interaction life threatening machine machine learning machine-learning mutated Mutation Mutation identification mutations nucleotide Pathogens performed Predictive Predictive prognosis Prognosis representing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severity Temporal Temporal benchmarking. Total variant variants Viral diseases virus [DOI] 10.1016/j.jmb.2022.167684 PMC 바로가기 [Article Type] Article
Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy Research Published on 2022-08-012022-10-05 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] approach association automatically Clinical data Combination complex Consensus COVID-19 severity disease severity Electronic health record Genetic genomes highest highlight HLA host genome impacted individual marker metagenomic Nasopharyngeal swab neurologic pandemic phenotype Population positive powerful tool Region reported reveal risk SARS-CoV-2 SARS-CoV-2 pandemic sequence severe COVID-19 susceptibility Transcriptome viral disease viral genome [DOI] 10.1038/s41467-022-32397-8 [Article Type] Research
Temporal lineage replacements and dominance of imported variants of concern during the COVID-19 pandemic in Kenya Research Published on 2022-08-012022-10-05 Journal: Communications Medicine [Category] 진단, 치료기술, [키워드] Analysis B.1 B.1 lineage B.1.1 Beta circulating variant COVID-19 epidemic COVID-19 pandemic Delta disease severity dominant European expand FIVE Genome genomes highlight Interpretation Kenya Lineage omicron phenotype remained Result SARS-CoV-2 lineage subsequent Surveillance Temporal Transmissibility Vaccine variant variants of concern virulence VoC Wave [DOI] 10.1038/s43856-022-00167-8 [Article Type] Research
Identification of conserved regions from 230,163 SARS-CoV-2 genomes and their use in diagnostic PCR primer design230,163 SARS-CoV-2 게놈에서 보존 영역 식별 및 진단 PCR 프라이머 디자인에서의 사용Article Published on 2022-08-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] addition Alpha amplification approach Beta bioinformatics can be used candidate Candidates characteristic conserved Coverage dataset Delta Diagnosis diagnostic Epsilon Eta evaluated exhibited False negative full-length Gamma genome sequence genomes genomic sequence GISAID GISAID EpiCoV database identification identify in silico Intensive Iota Multiple Multiple sequence alignment multiple sequence alignments NCBI nine NSP2 orf3a gene Outbreaks pandemic PCR PCR primer primer primer set primer sets Primers qPCR RdRP Region removal retrieved RNA sample RNA samples RT-qPCR S gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant sequence Sequence alignment target viral genome viral sequences was reduced Zeta [DOI] 10.1007/s13258-022-01264-7 PMC 바로가기 [Article Type] Article
Chromosomal-level reference genome assembly of the North American wolverine (Gulo gulo luscus): a resource for conservation genomics북미 울버린(Gulo gulo luscus)의 염색체 수준 참조 게놈 어셈블리: 보존 유전체학을 위한 리소스Article Published on 2022-07-292022-09-11 Journal: G3 (Bethesda, Md.) [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 aggression aggression genes aggressive behavior baseline Canada chromosomal-level assembly Climate change Complete conservation genomics contig coronavirus Coronavirus-2 Coronaviruses environmental disruption Final Genes Genetic Genome genome assembly genomes Gulo gulo Gulo gulo luscus heterozygous Infection innate immune system Innate immunity involved long-reads male management modality naïve North nucleotide Nunavut parasitic diseases Pathogens reference genome resource SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Single nucleotide variant specimen Support susceptibility viral pathogen viral pathogens wolverine wolverine. [DOI] 10.1093/g3journal/jkac138 PMC 바로가기 [Article Type] Article
Global genomic analyses of wheat powdery mildew reveal association of pathogen spread with historical human migration and trade Research Published on 2022-07-262022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] America Analysis association cause China Crescent disease Eurasia European Evolution genomes genomic Human hybridized Japan Local Migration pathogen recent Spread strain Strains USA [DOI] 10.1038/s41467-022-31975-0 [Article Type] Research
Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개Article Published on 2022-07-162022-09-11 Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘, [키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease [DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article
Phylogenetic analysis and comparative genomics of SARS-CoV-2 from survivor and non-survivor COVID-19 patients in Cordoba, Argentina아르헨티나 코르도바에서 생존자와 비생존자 COVID-19 환자의 SARS-CoV-2 계통발생 분석 및 비교 유전체학Article Published on 2022-07-142022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis association B.1 both groups carried Clinical characteristics Clinical outcome clinical outcomes Comorbidities Comorbidity Comparative Comparative genomics Complete Córdoba coronavirus cough COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patient COVID-19 patients Dyspnea Epidemiological study Evolution Evolution of SARS-CoV-2 Fever First wave functional Future Genes genome sequence Genome sequences genomes Genomic analysis genomic data groups Hospitalization in both groups incidence Infectious diseases Lineage majority Molecular epidemiology Mutation nasopharyngeal specimen Next-generation sequencing nine non-survivor Non-survivors Nsp3 outcomes pandemic Patient patients performed phylodynamic Prevalence Protein repertoire Research respiratory responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation SARS-CoV-2 pathogenesis SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variants SARS-CoV-2 virus Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 South America Specific specific mutation specific mutations Spike protein Spread survivor Survivors Symptom Symptoms the SARS-CoV-2 the Spike variant Variation was performed [DOI] 10.1186/s12864-022-08756-6 PMC 바로가기 [Article Type] Article
Host-Genome Similarity Characterizes the Adaption of SARS-CoV-2 to Humans숙주-게놈 유사성은 SARS-CoV-2의 인간 적응을 특징짓는다Article Published on 2022-07-122022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptability Alpha Analysis Beta coronavirus correlation dataset Delta delta variant evade evade immunity FIVE Frame Gamma Genome genomes help HGS high mutation rate highest Host host genome host genome similarity host innate immunity Human IFN-β immune system Immunity in vivo Indicator Innate immunity Interaction lowest mechanism Mutation mutation rate omicron Omicron variants Open reading frame ORF populations puzzle SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus shown signaling pathway similarity strain suppression variant variants viral genomes [DOI] 10.3390/biom12070972 PMC 바로가기 [Article Type] Article
Genomic epidemiology of Delta SARS-CoV-2 during transition from elimination to suppression in Aotearoa New Zealand뉴질랜드 Aotearoa에서 제거에서 억제로 전환하는 동안 Delta SARS-CoV-2의 게놈 역학Article Published on 2022-07-122022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] Border caused changed Cluster Clusters Community community transmission concern Contact tracing COVID-19 Delta delta variant epidemiological link Epidemiology frameshift Genome genomes Genomics lockdown New ORF7a outbreak Outbreaks Protein reported representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes Spread Surveillance [DOI] 10.1038/s41467-022-31784-5 PMC 바로가기 [Article Type] Article