CFD based analysis of 3D printed nasopharyngeal swabs for COVID-19 diagnosticsResearch article Published on 2022-08-012022-10-05 Journal: Computer methods and programs in biomedicine [Category] 진단, [키워드] 3D printing Additive Additive manufacturing Analysis approach assist CFD clinical testing clinical trial comparable Computational Fluid Dynamics (CFD) conditions conducted COVID-19 COVID-19 testing criteria diagnostics domain Efficacy Efficiency evaluate experiment geometric IMPROVE nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs NP swab NP swabs objective parameter predicted Result significant changes in Swab swabs Taguchi method Variability Volume Volume of Fluid method [DOI] 10.1016/j.cmpb.2022.106977 [Article Type] Research article
Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructuresSARS-CoV-2 스파이크 단백질과 DNA-펩티드 나노구조의 결합 상호작용 특성 규명Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Amino acid amino acid sequence analyte angiotensin angiotensin converting enzyme Beta binding binding interaction binding interactions binding modes capture characterization complement concentrations Corona virus DNA ELISA enzyme full-length spike protein geometric hACE2 immunosorbent inactivated increase in Interaction investigated moiety mono peptide Protein binding quantified Quantitative RBD receptor SARS-CoV-2 SARS-CoV-2 spike protein sequence Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus shown Spike protein Spike proteins subunit subunits tested the spike protein trimeric trivalent variant variations virus virus strain viruses while wild type [DOI] 10.1038/s41598-022-16914-9 PMC 바로가기 [Article Type] Article
Rapid and sensitive detection of viral particles by coupling redox cycling and electrophoretic enrichment산화환원 순환과 전기영동 농축을 결합하여 바이러스 입자를 신속하고 감도로 감지Article Published on 2022-07-152022-09-11 Journal: Biosensors & bioelectronics [Category] 치료기술, [키워드] amplification Amplification factor amplified Analysis calculate COVID-19 pandemic Critical Cycling droplet Early detection Effect Efficiency electric field Electrochemical sensor Electrophoresis Factor Field strength Frequency geometric IDE improvement Improvements magnitude mitigate MONITOR Outbreaks Particle Particle collision platform Rapid redox Redox cycling reduced viral loads viral particle virion virus virus detection widespread [DOI] 10.1016/j.bios.2022.114198 PMC 바로가기 [Article Type] Article
Immune response and safety to inactivated COVID-19 vaccine: a comparison between people living with HIV and HIV-naive individuals비활성화된 COVID-19 백신에 대한 면역 반응 및 안전성: HIV 감염자와 HIV 감염 경험이 없는 개인 간의 비교Article Published on 2022-07-052022-09-12 Journal: AIDS Research and Therapy [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI Adults Adverse reaction Antibody neutralization Antiretroviral therapy baseline binding antibody unit Biological CD4 chemiluminescence colloidal gold COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy ELISA enrolled Follow-up Frequency geometric geometric mean concentration GMC humoral immune response IgG IgG antibody IgG response immune immune response inactivated Inactivated COVID-19 vaccine individual injection NAb not different observation outcome peaked PLWH PLWH population PLWH. primary immunogenicity product remained response SARS-CoV-2 neutralizing antibody second dose Serious Adverse Events seroconversion rate shown Sinopharm specific IgM with HIV Wuhan [DOI] 10.1186/s12981-022-00459-y PMC 바로가기 [Article Type] Article
Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease종양 괴사 인자-α 길항제의 사용은 염증성 장 질환이 있는 백신 접종 환자에서 SARS-CoV-2에 대한 약화된 IgG 항체 반응과 관련이 있습니다Observational Study Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] Against age antagonist antagonists anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody concentrations Antibody titer Antibody titers Biologicals Blood blood sampling bowel Characteristics clinical Clinical characteristics Combination completion Concentration COVID-19 Crohn's disease defined demonstrated detectable disease Effect elapsed geometric geometric mean IBD IgG IgG antibodies IgG antibody IgG antibody titer IgG antibody titers immune response immunoassay immunomodulating Immunosuppressive medication immunosuppressive medications increased risk independent independent of Inflammatory Inflammatory bowel disease medication Microparticle monotherapy Most patients mRNA mRNA vaccines mRNA-based vaccine mRNA-based vaccines Multivariable models Patient patient age patients patients treated prospective observational cohort quantitative determination RBD receive receiving Receptor-binding domain regimen response S1 subunit sampling SARS-CoV-2 SARS-COV-2 infection Seroconversion serological response significantly lower Spike protein the receptor-binding domain the S1 subunit the spike protein titer TNF-α-antagonists treated Treatment Tumor ulcerative colitis vaccination Vaccine vector was used were measured were recorded [DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study
Comparison of anti-SARS-CoV-2 IgG and IgA antibody responses post complete vaccination, 7 months later and after 3rd dose of the BNT162b2 vaccine in healthy adults건강한 성인의 BNT162b2 백신 3차 접종 후 7개월 후와 완전 백신 접종 후 항 SARS-CoV-2 IgG와 IgA 항체 반응 비교Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered administration Adults anti-SARS-CoV-2 IgG antibody antibody levels Antibody Response approved BNT162b2 BNT162b2 vaccine booster booster dose Complete COVID-19 COVID-19 vaccine decrease domain dose ELISA assay European Medicines Agency geometric geometric mean healthy higher risk IgA IgA antibodies IgA antibody IgG individual individuals mRNA new SARS-CoV-2 of BNT162b2 Older Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants second dose semi-quantitative serum sample serum samples Significant significant decrease significantly tested the SARS-CoV-2 vaccinated individual vaccinated individuals vaccination Vaccine variant variants virus were assessed [DOI] 10.1016/j.jcv.2022.105193 PMC 바로가기 [Article Type] Article
Omicron infection enhances Delta antibody immunity in vaccinated personsOmicron 감염은 예방 접종을 받은 사람의 Delta 항체 면역을 향상시킵니다.Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absolute levels acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody immunity B.1.617.2 Beta BNT162b2 breakthrough infections coronavirus cross-protection Delta develop dominant elicit ENhance enrolment focus Follow-up follow-up time geometric geometric mean Immunity individual Infection interquartile range Johnson & Johnson median moderate neutralization neutralization capacity neutralization test neutralizing immunity offer omicron other variants participant Participants Pfizer Protective reduction respiratory severe acute respiratory syndrome Coronavirus South Africa Symptom symptom onset titre vaccinated individual vaccinated individuals vaccination variant variants virus Virus neutralization viruses [DOI] 10.1038/s41586-022-04830-x PMC 바로가기 [Article Type] Article
Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases만성 폐질환 환자에서 BNT162b2 COVID-19 백신 2회 접종 후 손상된 면역학적 결과와 관련된 항체 반응 및 위험 인자Article Published on 2022-07-012022-09-12 Journal: BMJ Open Respiratory Research [Category] MERS, 진단, [키워드] 1:1 1.26 95% CI adjusted antibody concentration Antibody Response aRR association Asthma bronchiectasis Charlson Comorbidity Index chronic pulmonary disease cohort study Comorbidity Control controls copd epidemiology COVID-19 COVID-19 vaccination COVID-19 vaccine defined dose Factor fibrosis first vaccination functional geometric healthcare personnel Humoral response identify immunological immunological responses Immunosuppression immunosuppressive Inclusion increasing age Interaction interstitial Interstitial Fibrosis lowest mRNA neutralising neutralising antibody of BNT162b2 outcome Patient Poisson regression Prednisolone Primary outcome Prospective quartile Receptor binding domain reported Responder response responses risk risk factor secondary outcome tested vaccination [DOI] 10.1136/bmjresp-2022-001268 PMC 바로가기 [Article Type] Article
Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trialResearch article Published on 2022-06-272022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료법, [키워드] 1:1 95% CI administration age Analysis Antibody Response Antibody titre Arthritis assigned atopic dermatitis booster Booster vaccine clinics COVID-19 COVID-19 vaccination COVID-19 vaccination programme COVID-19 vaccine data analyst Dermatology diagnosed domain dose Effect Efficacy evaluated female finding funding geometric geometric mean ratio GMR groups hospital Immune-mediated Immune-mediated inflammatory disease Immune-mediated inflammatory diseases Immunity inflammatory condition inflammatory disease inhibit intention-to-treat population interim analysis Intervention investigators Laboratory low-dose methotrexate mixed-effects model multicentre open label Open-label parallel-group participant Participants Patient platform Primary outcome randomisation randomised Randomly receiving recruited recruitment Registered Research researcher rheumatoid arthritis rheumatology SARS-CoV-2 SARS-COV-2 infection Serious Adverse Events Spike protein spondyloarthritis susceptible systemic lupus erythematosus the SARS-CoV-2 translate Treatment treatment as usual Trial Two-arm vaccination Vaccine vaccine dose Vaccine-induced immunity [DOI] 10.1016/S2213-2600(22)00186-2 [Article Type] Research article
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial6~17세 어린이 대상 ChAdOx1 nCoV-19(AZD1222) 백신의 안전성 및 면역원성: 2상 단일 맹검, 무작위, 대조 시험인 COV006의 예비 보고서Clinical Trial Published on 2022-06-112022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] 95% CI administration Adults adverse event adverse events age All participants anti-SARS-CoV-2 IgG antibody Antibody titre antibody titres arbitrary unit assigned AstraZeneca AZD1222 baseline capsular Cellular responses ChAdOx1 ChAdOx1 nCoV-19 children chronic respiratory conditions Concentration Controlled trial COVID-19 COVID-19 vaccine COVID-19 vaccines Cutoff Department dose doses Efficacy enrolled Fever first dose first vaccination four group four groups geometric geometric mean geometric mean ratios Geometric means group half-maximal inhibitory concentration Humoral response humoral responses immune response immune responses immunogenic immunogenicity in some intramuscular dose introduced investigators ISRCTN Laboratory laboratory-confirmed Laboratory-confirmed COVID-19 Local nucleocapsid protein Pain and tenderness participant Participants peaked Phase 2 phase 3 study preliminary report Primary outcome prime and boost raised randomised Randomly receive receiving recruitment Registered remained reported resolved respiratory response Safety safety population SARS-CoV-2 second dose second vaccination secondary outcome Serious Adverse Event Serious Adverse Events seronegative seronegative participant seronegative participants seropositive serostatus single-blind stratified study drug study groups tenderness Tolerability treatment allocation Trial vaccination Vaccine Viral viral particle were recorded [DOI] 10.1016/S0140-6736(22)00770-X PMC 바로가기 [Article Type] Clinical Trial