Inactivated SARS-CoV-2 vaccine in primary Sjögren’s syndrome: humoral response, safety, and effects on disease activity원발성 쇼그렌 증후군에서 비활성화된 SARS-CoV-2 백신: 체액 반응, 안전성 및 질병 활동에 대한 영향Clinical Trial Published on 2022-07-012022-09-12 Journal: Clinical Rheumatology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% CI activity Adverse age anti-SARS-CoV-2 autoantibody Autoimmune disease booster dose comparable Control controls COVID-19 Deleterious detrimental Disease activity dose Effect event female Frequency geometric mean titer GMT humoral IgG immunogenicity index IQR Mild moderate Neutralizing activity neutralizing antibody participant Patient patients Point S1/S2 Safe Safety SARS-CoV-2 SARS-CoV-2 vaccine Seroconversion Sex Sjögren’s syndrome syndrome Trial Vaccine were assessed [DOI] 10.1007/s10067-022-06134-x PMC 바로가기 [Article Type] Clinical Trial
Convalescent plasma donors show enhanced cross-reactive neutralizing antibody response to antigenic variants of SARS-CoV-2 following immunization회복기 혈장 기증자는 예방 접종 후 SARS-CoV-2의 항원 변이체에 대한 향상된 교차 반응성 중화 항체 반응을 보여줍니다Article Published on 2022-07-012022-09-11 Journal: Transfusion [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha anti-SARS-CoV-2 anti-spike antibody antibody Antibody neutralization antigenic antigenic variant antigenic variants antigenic variation automated Beta circulating convalescent convalescent plasma COVID-19 cross-reactive Delta determined by Donor dose Effect Elecsy focus geometric mean geometric mean titer GMT GMTs immunization infected with SARS-CoV-2 Live virus microneutralization NAb NAb titers NAbs neutralization neutralization potency neutralization test neutralize Neutralizing antibodies neutralizing antibody Neutralizing antibody response omicron Pfizer plasma Predictive prototype Quantitative reactivity reduction ROC analysis Roche Sample SARS-CoV-2 SARS-CoV-2 strain specificity strain Strains Therapeutic benefit therapy titers treat vaccination Vaccinations vaccine dose Zeneca [DOI] 10.1111/trf.16934 PMC 바로가기 [Article Type] Article
Safety and Immunogenicity of an Inactivated COVID-19 Vaccine, WIBP-CorV, in Healthy Children: Interim Analysis of a Randomized, Double-Blind, Controlled, Phase 1/2 Trial건강한 어린이에서 비활성화된 COVID-19 백신 WIBP-CorV의 안전성 및 면역원성: 무작위, 이중 맹검, 대조, 1/2상 시험의 중간 분석Clinical Trial Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] adverse events Adverse reaction Adverse reactions age alum Antibody Response assigned children China clinical trial Cohort cohorts conducted Controlled COVID-19 COVID-19 vaccine detectable dose dose-escalation double-blind effective vaccine Effective vaccines elicited Escalation Fever followed by geometric mean geometric mean titer geometric mean titers grade 3 groups healthy children Humoral response immunogenicity inactivated Inactivated vaccine injection injection site pain Interim Intramuscular injection Mild neutralizing antibody participant phase Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled Randomized Randomly ranged Registered robust Safe Safety safety profile SARS-CoV-2 significantly higher tested three group three groups vaccination Vaccine [DOI] 10.3389/fimmu.2022.898151 PMC 바로가기 [Article Type] Clinical Trial
Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccineBNT162b2 백신 3회 접종으로 Omicron BA.1, BA.2, BA.3 SARS-CoV-2 중화Article Published on 2022-06-232022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] collected Complete dose facilitate geometric mean titer GMTs implication initial less mNeonGreen neutralization neutralize neutralized of BNT162b2 omicron Prevalence replaced SARS-CoV-2 sera SRAS-CoV-2 USA-WA1/2020 Vaccine virus [DOI] 10.1038/s41467-022-30681-1 PMC 바로가기 [Article Type] Article
Antibody Responses to SARS-CoV-2 in Children With COVID-19COVID-19에 걸린 어린이의 SARS-CoV-2에 대한 항체 반응Article Published on 2022-06-222022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed anti-S IgG anti-SARS-CoV-2 IgG Anti-spike antibody antibody level antibody levels Antibody Response Asymptomatic blood sample Blood samples caused children children with COVID-19 conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Cutoff detectable effective evaluate feature geometric mean geometric mean titer geometric mean titers GMT GMTs highest humoral immune response humoral immune responses IgG immune responses immune system Infection longitudinal study neutralizing antibody peaked positive positive rate positive rates reached remained respiratory response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus South Korea symptom onset symptomatic Vaccine development were measured with COVID-19 [DOI] 10.1093/jpids/piac012 PMC 바로가기 [Article Type] Article
Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infectionArticle Published on 2022-06-072022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome benefit boost cellular clinical trial convalescent coronavirus coronavirus disease COVID-19 COVID-19 vaccine dose doses driving effective vaccine Efficacy evaluated geometric mean titer GMT greater Heterologous highlighting homologous human sera humoral immune response immune response immunize low dose lower airways mice mRNA mRNA vaccine NAb neutralizing antibody non-human primate non-human primates offer pandemic populations prefusion prime-boost regimen Protective protective immunity provided reduction regimen regimens replicate rhesus macaque rhesus macaques RNA vaccines Safe SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine spike glycoprotein Spread T cell response tested Translational immunology vaccination Vaccine viral replication [DOI] 10.1038/s41467-022-31005-z PMC 바로가기 [Article Type] Article
Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV: a phase 2 trialBBIBP-CorV로 프라이밍한 후 이종 부스터로서의 NVSI-06-07의 면역원성과 안전성: 2상 시험Clinical Trial Published on 2022-06-062022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 1:1 Adverse reactions Alpha assigned BBIBP-CorV Beta boost booster booster vaccination conducted control groups coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta double-blinded elicited followed by geometric mean geometric mean titer GMT GMTs group groups healthy Heterologous heterologous prime-boost homologous immunogenic immunogenicity immunogenicity assays inactivated increase Increases indicated individual Mild moderate Neutralizing neutralizing antibody omicron Omicron variant Participants Phase 2 phase 2 trial priming prototype randomised Randomly receive recipient Recombinant protein Safe safety profile SARS-CoV-2 SARS-CoV-2 variant significantly higher systemic adverse reaction three groups vaccination Vaccine variant VOCs [DOI] 10.1038/s41392-022-00984-2 PMC 바로가기 [Article Type] Clinical Trial
Dynamics of anti-Spike IgG antibody level after the second BNT162b2 COVID-19 vaccination in health care workers의료 종사자의 두 번째 BNT162b2 COVID-19 예방 접종 후 항-스파이크 IgG 항체 수준의 역학Article Published on 2022-06-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition Adverse reaction age alcohol allergies allergy anti-Spike IgG Anti-spike IgG antibody anti-spike IgG level anti-spike IgG levels Antibody titer association BMI BNT162b2 categories correlation country COVID-19 COVID-19 vaccination COVID-19 vaccines cross-sectional dose Dynamics evaluate Fever geometric mean titer Health care worker IgG IgG antibody Japanese observation Older Older age participant remained second vaccination Sex Side effect significantly significantly lower smoking statistically significant vaccination vaccine dose Vaccine-induced immunity was performed were assessed [DOI] 10.1016/j.jiac.2022.02.024 PMC 바로가기 [Article Type] Article
Adequacy of Hemodialysis Serves as an Independent Predictor of Humoral Response to ChAdOx1 Prime-Boost Vaccination in Hemodialysis Patients혈액 투석의 적절성은 혈액 투석 환자의 ChAdOx1 프라임 부스트 백신 접종에 대한 체액 반응의 독립적인 예측 인자로 작용합니다Article Published on 2022-05-262022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 1.26 acute respiratory syndrome Adequacy analyzed ANOVA antibody applied ChAdOx1 coronavirus correlation COVID-19 COVID-19 vaccine dialysis domain dose enrolled enzyme-linked immunosorbent evaluate geometric mean titer healthy control healthy subject Hemodialysis hemodialysis adequacy Multiple linear regression neutralization neutralization titer Neutralizing Neutralizing antibodies neutralizing antibody Oxford-AstraZeneca parameter Patient predict predictor Prospective Study quantification regression analysis response Seroconversion seronegative seropositive subject the spike protein vaccination Vaccine [DOI] 10.3390/v14061149 PMC 바로가기 [Article Type] Article
Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2BA.2 및 BA.3 SARS-CoV-2에 대한 Omicron BA.1의 교차 중화Article Published on 2022-05-262022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] COVID-19 vaccine cross-neutralization Frequency geometric mean titer GMT GMTs Heterologous homologous human sera implication initial neutralization neutralize Neutralizing omicron replaced responsible SARS-CoV-2 sera [DOI] 10.1038/s41467-022-30580-5 PMC 바로가기 [Article Type] Article