Baidu Jieduan granules, traditional Chinese medicine, in the treatment of moderate coronavirus disease-2019 (COVID-19): study protocol for an open-label, randomized controlled clinical trial중등도 코로나바이러스 질병-2019(COVID-19) 치료에 사용되는 중국 전통 의학 Baidu Jieduan 과립: 공개, 무작위 대조 임상 시험을 위한 연구 프로토콜Study Protocol Published on 2021-07-222022-09-10 Journal: Trials [Category] SARS, 임상, 치료제, [키워드] 1:1 absence Adverse adverse events AEs Antibiotics antiviral medicine applied Baidu Baidu Jieduan granule baseline Chinese circulating clinical Clinical efficacy clinical evidence conducted control group Controlled clinical trial Controlled trial coronavirus coronavirus disease coughing COVID-19 develop Effect effective Efficacy and safety epidemic disease epidemic diseases evaluate event experimental group fatigue Fever Glucocorticoids Granule granules Health moderate Moderate COVID-19 multicentre Open-label outcome Patient patients with COVID-19 Primary outcome Randomized Randomized controlled trial Randomly receive registry resulting Standard therapy Study protocol supplementary material Support Symptom TCM theory Traditional Chinese medicine treating COVID-19 Treatment treatment group treatment initiation Trial twice a day use of antibiotics [DOI] 10.1186/s13063-021-05418-y PMC 바로가기 [Article Type] Study Protocol
Salivary glands are a target for SARS-CoV-2: a source for saliva contamination침샘은 SARS-CoV-2의 표적입니다: 타액 오염의 원인Article Published on 2021-07-012022-09-11 Journal: The Journal of pathology [Category] SARS, 치료기술, 치료법, 치료제, [키워드] ACE2 acinar cell age alteration analysis Analysis analyzed anti-SARS-CoV-2 antibody Autopsy biopsy Cell cells change characterized Cluster conducted Contamination Coronaviridae family COVID-19 COVID-19 pandemic cytoplasm cytoplasmic degeneration degenerative determinant determinants Diagnostic method duct electron microscopy enlarged nuclei epithelial cell epithelial cells expression female Granule Great Britain highlight histopathological identify immunohistochemistry infected cell infected cells Infection infection control Ireland lining epithelium male Microscopy nasopharyngeal swabs New coronavirus new coronavirus SARS-CoV-2 nuclear nuclear pleomorphism nucleocapsids organelle pathological pathophysiological Patient patients positive profile Qualitative Quantitative receptors reservoir RT-PCR RT-PCR, SARS-CoV-2 RT-qPCR Saliva salivary salivary gland salivary gland. salivary glands Sample SARS-CoV-2 sensitivity shape Society Sons Spread tested the Coronaviridae the disease TMPRSS Ultrasound vacuolization Viral particles viral replication [DOI] 10.1002/path.5679 PMC 바로가기 [Article Type] Article
Efficacy and safety of Xuanfei Baidu granules for treating COVID-19 A protocol for systematic review and meta-analysis코로나19 치료를 위한 Xuanfei Baidu 과립의 효능 및 안전성 체계적인 검토 및 메타 분석을 위한 프로토콜 A4400 Published on 2021-05-212022-08-31 Journal: Medicine [Category] meta-analysis, SARS, 임상, 치료제, [키워드] Analysis average Baidu bias risk carried checked China Chinese clinical symptom Computed tomography Corona corona virus disease 2019 country COVID-19 COVID-19 diagnosis COVID-19 patient database Diagnosis disease effective Efficacy and safety evaluate evaluated evaluator Evidence extraction Granule Health Hospital stay include Infrastructure Intervention journal knowledge list lung management Meta Meta-analysis Negative conversion nucleic acid plan prevalent protocol Randomized controlled trials registration number registry released responsible review Science searched statistical systematic review technology Traditional Chinese medicine treating COVID-19 Treatment treatment of COVID-19 Trial Virus Disease Web website Wuhan Wuhan, China Xuanfei Baidu granule [DOI] 10.1097/MD.0000000000025653 PMC 바로가기 [Article Type] 4400
Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature MiningPharmacology Published on 2021-05-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] addition administration Against analyzed Anti-viral anti-viral responses antiviral activity broad-spectrum antivirals Capacity Capsule China Chinese clinical outcomes combined treatment COVID-19 drug Efficacy exhibit exhibited Fatality rate food function Granule Host Host immune response host-directed therapy immune function infected patient Inflammation International Jin-Hua-Qing-Gan granule Lian-Hua-Qing-Wen capsule literature medicinal plants Medicine modulating novel coronavirus disease Patient pharmacological SARS-CoV-2 Statistics Symptom the disease Traditional Treatment variety viral infections viral life cycle [DOI] 10.3389/fphar.2021.640782 PMC 바로가기 [Article Type] Pharmacology
Guangdong’s experience in defeating the COVID-194900 Published on 2021-05-072022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] activating China confirmed case contributed cough country COVID-19 COVID-19 epidemic COVID-19 pandemic Critical drugs Effect epidemic control policy Fever Granule growth Guangdong Guangdong Province hospital initial magnitude phase press public health Quantitative suspected patient Treatment with COVID-19 [DOI] 10.1097/MD.0000000000025881 PMC 바로가기 [Article Type] 4900
Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching2019년 중국 우한에서 발생한 중증 코로나바이러스 질환 환자에서 한약 과립의 효과 및 안전성: 성향 점수 매칭을 통한 후향적 단일 센터 연구Article Published on 2021-05-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 치료제, [키워드] 1:1 28-day mortality baseline category caused Chinese Chinese herbal medicine CHM Clinical improvement Computerized tomography coronavirus disease Coronavirus disease 2019 cough COVID-19 D-dimer level Day defined duration of fever Dyspnea Effect Fever fibrinolysis Granule granules Health herbal medicine high risk hospital lung lung lesion male no significant difference Ordinal Scale Patient patients treated Primary outcome propensity score matching propensity score matching. PSM reduced retrospective Retrospective study severe coronavirus disease severe COVID-19 significant difference single-center single-center study the patient Treatment treatment effect usual care usual care alone was used Wuhan [DOI] 10.1016/j.phymed.2020.153404 PMC 바로가기 [Article Type] Article
A Network Pharmacology Study to Uncover the Multiple Molecular Mechanism of the Chinese Patent Medicine Toujiequwen Granules in the Treatment of Corona Virus Disease 2019 (COVID-19)코로나 바이러스 질병 2019(COVID-19) 치료에서 중국 특허 의학 Toujiequwen 과립의 다중 분자 메커니즘을 밝히기 위한 네트워크 약리학 연구Article Published on 2021-04-012022-08-31 Journal: Current medical science [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] affected Analysis antiviral drug antiviral drugs applied cardiovascular disease cardiovascular diseases cellular response Chinese Corona COVID-19 cytokine cytokine receptor digestive tract disease Diseases DPP4 drug drug target effective Endocrine enrichment analysis Evidence functions GO analysis Granule granules in viral ingredient Interaction Intervention KEGG lipopolysaccharide Medicine molecular molecular mechanism Multiple network network analysis network pharmacology novel corona virus outbreak Patent Patent Medicine Pathogenesis pathogenesis of COVID-19 pathway patients with COVID-19 pharmacological Pharmacology promoted Protein PTGS1 PTGS2 quercetin signaling pathway significantly Symptom target target. Toujiequwen granules Treatment treatment of COVID-19 underlying disease underlying diseases Viral Virus Disease [DOI] 10.1007/s11596-021-2346-x PMC 바로가기 [Article Type] Article
Understanding COVID-19 in Wuhan From the Perspective of Cold-Dampness: Clinical Evidences and MechanismsMedicine Published on 2021-02-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 addition association Cell Characteristics city clinical Clinical efficacy clinical evidence cold-dampness cold-dampness plague theory coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Cytokines dropping drugs etiological experiment Formula Granule immune response Infectious disease mechanism Mild moderate pulmonary fibrosis randomized clinical trial randomized clinical trials retrospective cohort SARS-CoV-2 stages suggested TCM the epidemic therapeutic Traditional Chinese medicine Treatment understanding Wuhan [DOI] 10.3389/fmed.2021.617659 PMC 바로가기 [Article Type] Medicine
Yindan Jiedu Granules, a Traditional Chinese Medicinal Formulation, as a Potential Treatment for Coronavirus Disease 2019Pharmacology Published on 2021-02-052022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 1:1 addition adverse effect Analysis analyzed baseline CD4 Characteristics Chinese coronavirus disease COVID-19 COVID-19 patient disease duration of fever Efficacy Factor Fever Formulation Granule herbal medicine independent individual lesion lesions Lopinavir-ritonavir Median recovery time Patient patients with COVID-19 Potential Predictive presenting Propensity score proportion PSM pulmonary exudative lesions recovered patient recovery proportion reveal significantly shorter standard care the Kaplan-Meier method the mean Toxicity Traditional Treatment treatment groups two groups was used Yindan Jiedu granules [DOI] 10.3389/fphar.2020.634266 PMC 바로가기 [Article Type] Pharmacology
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas Research Published on 2021-02-032022-10-05 Journal: Nature metabolism [Category] 치료기술, [키워드] acute respiratory syndrome Cell cells changes clinical contribute coronavirus coronavirus disease COVID-19 diabete dysregulation Endocrine Ex vivo experimental evidence Express functional Glucose Granule homoeostasis identify impair in vivo infect Infection insulin investigated islet islets marker Morphological pancrea pancreatic Patient patients with COVID-19 positive postmortem examinations Protein Proteins reduced replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid secretion tissue transcriptional viral entry β-cell [DOI] 10.1038/s42255-021-00347-1 [Article Type] Research