Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링Article Published on 2022-08-042022-09-11 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제, [키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication [DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article
Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects짧은 이중 가닥, 평활 말단 RNA의 서열 특이적 특징은 RIG-I 및 유형 1 인터페론 의존성 또는 독립적 항바이러스 효과를 갖는다Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] adaptors Adenovirus Anti-viral anti-viral effect Antiviral Antiviral agents Antiviral effect antiviral effects assays Cell cell cycle cell cycle genes cell line cells cellular complementary cytoplasmic DNA DNA virus downregulated dsRNA dsRNAs Effect elicited fibroblast Gene Expression H3N2 human airway IFN IFN-alpha IFN-I IFNAR2 independent independent of indicated Infection Influenza influenza A influenza A virus Influenza virus interferon knock-out library MDA5 mechanism mimicking molecular patterns MYD88 organism Organisms pathogen pathogen-associated molecular patterns Pathogens Randomized receptor required retinoic acid retinoic acid-inducible gene I RIG-I RNA RNA therapy RNA virus RNAs SARS-CoV-2 sequence short double-strand blunt-end RNA. transcriptomics transfection Type ZNFX1 [DOI] 10.3390/v14071407 PMC 바로가기 [Article Type] Article
Targeted Virome Sequencing Enhances Unbiased Detection and Genome Assembly of Known and Emerging Viruses-The Example of SARS-CoV-2표적 바이롬 시퀀싱은 알려진 바이러스와 새로 출현하는 바이러스의 편견 없는 탐지 및 게놈 조립을 향상시킵니다-SARS-CoV-2의 예Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adenovirus assembly cDNA cDNA synthesis characterization coronavirus COVID-19 coxsackievirus cytomegalovirus depleting detection Detection sensitivity DNA and RNA dsDNA Efficiency emerging viruses equimolar evaluate followed by genetic diversity genome assembly genomic H3N2 Illumina Influenza influenza A influenza A virus less mapped Nanopore nanopore sequencing NGS NGS diagnostics OC43 pathogen Pathogens point-of-care pool positive sample proof remained respiratory syncytial virus RNA virus RNA viruses SARS-CoV-2 sequence Sequencing strain Strains synthesis target enrichment total read viral genomes virome sequencing. virus viruses was performed [DOI] 10.3390/v14061272 PMC 바로가기 [Article Type] Article
Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021-22 Northern Hemisphere influenza season2021-22 북반구 인플루엔자 시즌을 계속 지배하는 H3N2 변이체의 항원 및 바이러스 특성Article Published on 2022-05-312022-09-11 Journal: Cell Reports [Category] 변종, [키워드] Alter antibodies antibody antigenic antigenic mismatch binding COVID-19 pandemic CP: Microbiology elicited glycosylation site H3N2 H3N2 strain hemagglutinin Hemisphere human airway cells human cell human cells Influenza influenza vaccine Influenza virus influenza viruses maintain Microbiology neutralize population immunity replicate sialic acid Substitution These data these viruses Vaccine vaccine strain variant Virological virus [DOI] 10.1016/j.celrep.2022.110897 PMC 바로가기 [Article Type] Article
Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus Research Published on 2022-05-022022-10-05 Journal: Nature Communications [Category] 변종, 신종인플루엔자, 치료제, [키워드] Amino acid antibody antigenic antiviral drugs binding characterized circulating conformational conserved Critical cross-neutralization dependent on determinant determine effective ENhance epitope functional fusion peptide germline gene H1N1 H3N2 IAV in vitro in vivo influenza A virus influenza vaccine Influenza virus Lineage MOST neutralize neutralizing antibody reactivity residue selected strain virus [DOI] 10.1038/s41467-022-29950-w [Article Type] Research
Bivalent H1 and H3 COBRA Recombinant Hemagglutinin Vaccines Elicit Seroprotective Antibodies against H1N1 and H3N2 Influenza Viruses from 2009 to 2019Article Published on 2022-04-132023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] Bivalent bivalent vaccine broadly reactive antibody Cobra cocktail H1N1 H3N2 hemagglutinin hemagglutinin vaccine Imprinting Influenza preimmunity universal influenza. [DOI] 10.1128/jvi.01652-21 PMC 바로가기
Protective effect of bivalent H1N1 and H3N2 VLP vaccines against Eurasian avian-like H1N1 and recent human-like H3N2 influenza viruses in a mouse modelArticle Published on 2022-03-012023-06-23 Journal: Veterinary microbiology [Category] 신종인플루엔자, [키워드] H1N1 H3N2 Swine influenza Vaccine Virus-like particle [DOI] 10.1016/j.vetmic.2022.109370
Characterization of a 2016-2017 Human Seasonal H3 Influenza A Virus Spillover Now Endemic to U.S. SwineArticle Published on 2022-02-232023-06-23 Journal: mSphere [Category] 신종인플루엔자, [키워드] H3.2010.2 H3N2 human-to-swine spillover influenza A virus reverse zoonosis swine [DOI] 10.1128/msphere.00809-21 PMC 바로가기
Conserved topology of virus glycoepitopes presents novel targets for repurposing HIV antibody 2G12Article Published on 2022-02-162022-10-29 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 신종인플루엔자, [키워드] Analysis antibody bind binding breadth Critical defined develop diagnostic Drug discovery epitope Factor functional glycan glycoprotein gp120 H1N1 H3N2 high-mannose HIV antibody host antibody host immunity identify include interactions lab lineages manuscript offer presenting Protein Protein Data Bank SARS-CoV-2 structural biology target therapeutic These data Topology viral surface virus virus–host interactions viruses [DOI] 10.1038/s41598-022-06157-z PMC 바로가기 [Article Type] Article
Evolution of Viral Pathogens Follows a Linear OrderResearch Article Published on 2022-02-022022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, 신종인플루엔자, [키워드] acute respiratory syndrome addition Amino acid Analysis contribute coronavirus coronavirus disease COVID-19 dengue virus determine distribution Evidence Evolution H1N1 H3N2 HCoV-229E HCoV-NL63 HCoV-OC43 Infectious disease influenza A linear linear order MERS MERS-CoV Microbiology Middle East outbreak Outbreaks predict random reveal SARS-CoV SARS-CoV-2 serotype shown subsequent syndrome triggering Vaccine variants of concern viral family viral genome viral mutation viral pathogen virus Zaire Zika [DOI] 10.1128/spectrum.01655-21 PMC 바로가기 [Article Type] Research Article