Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden Research Published on 2022-07-252022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] activated Affect age Analysis Cancer changes in characterization Cohort Combination deficiency DNA DNA methylation Effect EpiC Epigenetic expression Factor Factors Genome Health healthy healthy individual human monocytes Illumina IMPROVE individual investigated involved knowledge marker medication Mental Methylation molecular Numerous occur Older pathway Pathways performed physical activity Prevalence Regulation shown SLC25A24 study cohort study participant Treatment Vitamin D Vitamin D receptor Vitamin D supplementation Wnt pathway [DOI] 10.1038/s41598-022-15924-x [Article Type] Research
Local and Systemic Immunity Are Impaired in End-Stage-Renal-Disease Patients Treated With Hemodialysis, Peritoneal Dialysis and Kidney Transplant Recipients Immunized With BNT162b2 Pfizer-BioNTech SARS-CoV-2 VaccineBNT162b2 화이자-바이오엔텍 SARS-CoV-2 백신을 접종한 혈액투석, 복막투석, 신장이식 환자 말기 신장질환 환자의 국소 및 전신 면역 손상Article Published on 2022-07-222022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed anti-S anti-S IgG antibodies antibody binding antibody unit BNT162b2 cellular component clinical control group COVID-19 COVID-19 in patient COVID-19 vaccine dose effective End-stage renal disease ESRD Guidance HD group healthy individual Hemodialysis high mortality rate highest IFN-γ IgA IgG Immunity Immunoglobulin G Impaired Interferon-gamma investigated kidney transplant recipient Local Messenger RNA MONITOR mRNA participant Patient patients performed Peritoneal dialysis Pfizer Pfizer-BioNTech positive produced recipient required Research Responder SARS-CoV-2 Seroconversion seroconversion rate seronegative patient seropositive subjects systemic tested therapy Transplant transplantation. Trial registration Vaccine vaccine response [DOI] 10.3389/fimmu.2022.832924 PMC 바로가기 [Article Type] Article
Alterations in the molecular composition of COVID-19 patient urine, detected using Raman spectroscopic/computational analysis라만 분광/전산 분석을 사용하여 감지한 COVID-19 환자 소변의 분자 구성 변화Article Published on 2022-07-182022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Abnormalities Accuracy affected alteration Analysis analyzed Bladder cancer Care Chain Reaction Chromatography Clinical pathology collected complex component components computational analysis Contact contact with contributing to correlation correlations COVID-19 COVID-19 disease COVID-19 patient creatinine defined detect determine disease disease severity EGFR elevated fingerprint gas chromatography Gas Chromatography-Mass Spectrometry GC-MS glomerular filtration rate healthy healthy individual healthy individuals Hospitalized HPLC identify in urine include Infection Inflammatory liquid Liquid chromatography Long mass spectrometry metabolomic analysis Mild moderate molecular Negative predictive value pathology Patient patients performance Peritoneal dialysis positive Positive predictive value Predictive value Raman spectroscopy random ranged reaction representing respiratory RT-PCR SARS-CoV-2 virus sensitivity serum creatinine severity specificity specimen specimens Spectrometry Symptom symptomatic tested Urinalysis Urine urine specimens Viral Volunteer with COVID-19 [DOI] 10.1371/journal.pone.0270914 PMC 바로가기 [Article Type] Article
A comprehensive evaluation of the immune system response and type-I Interferon signaling pathway in hospitalized COVID-19 patients입원한 코로나19 환자의 면역 체계 반응 및 I형 인터페론 신호 전달 경로에 대한 종합 평가Article Published on 2022-07-162022-09-12 Journal: Cell Communication and Signaling : CCS [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abstract association autoantibody B lymphocyte CD4 CD8 conditions conducted COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine decrease downstream dysregulation ELISA enrolled enzyme-linked immunosorbent evaluate evaluated expression expression level Factor flow cytometry Frequency healthy controls healthy individual hospitalized COVID-19 patient IFN-I IFN-I signaling IFN-α IFN-β IL-10 IL-17 IL-1β IL-6 illness Illness severity Immune cell immune system Immune-phenotype investigated IRF life-threatening material Mild Mild symptom NK cell NK cells Numerous Pathogenesis pathway Patient positive Protein protein levels Real-time PCR reduced Regulatory RNA SARS-CoV2 sera severity signaling molecule signaling molecules signaling pathway Signaling pathway. significant decrease Th17 TNF-α Treatment Treg Treg cell Vaccines virus [DOI] 10.1186/s12964-022-00903-6 PMC 바로가기 [Article Type] Article
Third COVID-19 vaccine dose boosts neutralizing antibodies in poor responders Research Published on 2022-07-112022-10-05 Journal: Communications Medicine [Category] 치료기술, [키워드] age average BNT162b2 boost COVID-19 vaccine determine disease dose elicit evaluated female generate healthy individual increase in individual Infection males Moderna mRNA vaccine mRNA-1273 mRNA-1273 vaccine NAb NAbs neutralized neutralizing antibody not neutralize Pfizer potential transmission PROTECT recipient Responder response Result reveal second dose Vaccine vaccine dose while [DOI] 10.1038/s43856-022-00151-2 [Article Type] Research
CRISPR-based assays for rapid detection of SARS-CoV-2SARS-CoV-2의 신속한 검출을 위한 CRISPR 기반 분석Review Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] best COVID-19 CRISPR CRISPR Diagnostics diagnosis of SARS-CoV-2 Diagnostic advancements diagnostic test diagnostic tests diagnostics effective effort Epidemiology Establishing global public health gold gold standard healthy individual healthy individuals infected patient Instrumentation isothermal limitation molecular testing nucleic acid nucleic acids overcome pandemic quarantine reagent reagents required SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2. serological test Serological tests the disease Treatment while [DOI] 10.1016/j.ymeth.2020.10.003 PMC 바로가기 [Article Type] Review
Saliva changes in composition associated to COVID-19: a preliminary studyCOVID-19와 관련된 타액 조성 변화: 예비 연구Article Published on 2022-06-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Activation ACTN4 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Anosmia antibody ANXA4 Asymptomatic CA6 can be used caused changes in clinical presentation Clinical presentations composed control group coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID 19 COVID-19 COVID-19 group diagnostic diagnostics disease Diseases downregulation dysgeusia FGB FIVE healthy healthy individual immune response involved Mild mild COVID-19 patient mild COVID-19 patients occur oxidative damage pathophysiology Patient patients patients with COVID-19 Perspective positive Potential biomarker potential biomarkers Protective Protein proteome proteomic study proteomics pulmonary tissue quantification respiratory complication Respiratory complications RT-PCR Saliva saliva samples salivary SARS-CoV 2 separated severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 stimulus taste perception tested TGM3 the disease tissue Treatment two groups upregulation variety viral infection virus [DOI] 10.1038/s41598-022-14830-6 PMC 바로가기 [Article Type] Article
Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severityCOVID-19 중증도에 따른 장내 세균총 및 미생물총의 종단적 변화Article Published on 2022-06-242022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] abundance alteration analyzed Bacterial Bacteroides Candida Candida albicans characteristic characterized Community comparable condition correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity decrease discharge Enterococcus Faecalibacterium Follow-up fungal group groups Gut healthy healthy individual in some increase in lactobacillus longitudinal Lower metagenomic sequencing microbial microbiota Mild mild cases mild patients MONITOR Mycobiota Mycobiota. no difference no differences Patient patients with COVID-19 positively correlated remained SARS-COV-2 infection severe cases severe COVID-19 severe group severe patients the healthy [DOI] 10.1186/s12879-022-07358-7 PMC 바로가기 [Article Type] Article
Specific Antibody and the T-Cell Response Elicited by BNT162b2 Boosting After Two ChAdOx1 nCoV-19 in Common Variable Immunodeficiency공통 가변성 면역 결핍증에서 2개의 ChAdOx1 nCoV-19 후 BNT162b2 부스팅에 의해 유도된 특정 항체 및 T-세포 반응Article Published on 2022-06-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 immunoglobulin Anti-spike antibody autologous BNT162b2 BNT162b2 vaccine booster vaccination CD19 CD19+ CD3+ CD3+CD4+ CD3+CD8+ CD4+ CD45 CD45+ CD8+ Cell cell count cell counts cell-mediated response ChAdOx1 ChAdOx1 nCoV-19 changes in common common variable immunodeficiency common variable immunodeficiency (CVID) Control Coronavirus-2 COVID-19 infection cumulative cut-off value CVID decrease ELISPOT ELISpot assay evaluated except for flow cytometric healthy control healthy controls healthy individual healthy individuals humoral IFN-γ IFN-γ ELISPOT IFN-γ ELISpot assay IFN-γ producing T cells immune response immunodeficiency Immunoglobulin Immunoglobulin G immunosuppressive immunosuppressive therapy individual interferon interferon-γ Killer cell less Lymphocytes measure morbidity natural killer natural killer cell not different not significant Patient patients positive Primary Immunodeficiency producing protein S raised receiving response Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown Side effects significant difference significant differences significantly significantly lower Specific statistically stem cell Stem cell transplantation T cell T cell response T cells tested therapy These data vaccination vaccination. Vaccinations variable virus-specific T cell virus-specific T-cell with COVID-19 [DOI] 10.3389/fimmu.2022.907125 PMC 바로가기 [Article Type] Article
Immunogenicity of COVID-19 Vaccination in Patients With End-Stage Renal Disease Undergoing Maintenance Hemodialysis: The Efficacy of a Mix-and-Match Strategy유지 혈액투석을 받고 있는 말기 신질환 환자에서 코로나19 백신 접종의 면역원성: 혼합 및 일치 전략의 효능Article Published on 2022-06-132022-09-12 Journal: Journal of Korean medical science [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activity acute respiratory syndrome antibody analysis binding antibody blood sample ChAdOx1 collected comparable coronavirus coronavirus disease COVID-19 COVID-19 vaccine dose End-stage renal disease ESRD evaluate first vaccination healthy healthy individual Hemodialysis hospital immunogenicity Laboratory maintenance mix-and-match neutralizing antibody participant Patient quantified receiving recruited SARS-CoV-2 SARS-CoV-2 neutralizing antibody second dose serum and plasma significantly higher Spike protein Strategy the SARS-CoV-2 vaccination vaccine dose vaccine. were measured [DOI] 10.3346/jkms.2022.37.e180 PMC 바로가기 [Article Type] Article