Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications?Commentary Published on 2020-07-162022-10-31 Journal: Diabetology & Metabolic Syndrome [Category] COVID-19, [키워드] Activation adaptive amplification Anti-inflammatory benefit chronic complications coronavirus disease Coronavirus infection Cytokine storm develop diabete Evidence explain Heat shock Heat shock response HSR Hypothesis impair IMPROVE individual infected individual Infection Inflammation Inflammatory Inflammatory response innate immune responses involved metabolic disease Metabolic diseases multiple organ failure obesity outbreak outcome Pathogenesis pathway Patient patients patients with SARS-CoV-2 recent reduced resulting SARS-CoV-2 SARS-COV-2 infection Septic shock severity the disease therapy tissues turn type 2 diabete various tissues [DOI] 10.1186/s13098-020-00572-w PMC 바로가기 [Article Type] Commentary
Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes모노티올 글루타레독신 Grx3의 단백질체 프로파일링은 철 의존적 과정의 조절에서 그것의 전체적인 역할을 보여줍니다Research Article Published on 2020-06-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affinity purification amplify applied approach associations biological processes Candida albican Candida albicans Cell cellular processes cofactor commensal component conserved Critical cytosolic determine DNA essential nutrient expression function functions fungal Gene Expression genotoxic glutaredoxin growth Grxs Heat shock histidine homeostasis Host human host humans in vivo interact iron iron homeostasis leucine maintain mass spectrometry metabolism mutant organism Organisms oxidative oxygen pathogen Pathogens performed Protein protein translation proteomic regulate Regulation regulatory circuit repair repression required respond reveal sulfur Support survival Taking target gene Target genes the cell Tryptophan utilization virulence [DOI] 10.1371/journal.pgen.1008881 PMC 바로가기 [Article Type] Research Article
Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response인간 나병 병변의 이중 RNA-시퀀싱은 숙주 면역 반응과 관련된 세균 결정 인자를 식별합니다.Article Published on 2019-03-262024-08-24 Journal: Cell Reports [Category] 한센병, [키워드] bioinformatics Computational biology Heat shock host-pathogen humoral immunology Microbiology mycobacteria Plasma cell Sequencing systems immunology Transcriptome translational Tuberculosis
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine스트레스 반응 및 대사 유전자 조절은 낮은 S-아데노실메티오닌에서 변경됩니다.Research Article Published on 2018-11-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated activating Acute stress affected alcohol analyzed animal animals assays Bacterial Caenorhabditis elegan Caenorhabditis elegans choline chromatin cystic fibrosis deficiencies deficiency disease Disease progression DNA Donor elegan elegans enzyme Enzymes exacerbate expression fibrosis Gene Expression Gene regulation Genes Genetic group Heat shock heat stress histone Histones in some influence less metabolism metabolite methionine methyl groups Methylation Modification modify nucleic acid organism Organisms pathogen Phosphatidylcholine Phospholipids produced Protective provide Reactions reduced Regulation required respond response responses RNA S-adenosylmethionine SAM Stress stress conditions survival tissue injury Transcription transcriptional response transcriptional responses variety [DOI] 10.1371/journal.pgen.1007812 PMC 바로가기 [Article Type] Research Article
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target spaceHsf1 수준을 조정하면 고갈이 Hsp90 기능을 손상시키고 과발현이 대상 공간을 확장하여 독특한 곰팡이 형태 발생 프로그램을 구동합니다.Research Article Published on 2018-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence bypassing Candida albican Candida albicans cellular changes in chaperone complex conserved Control Critical defend Depletion developmental dose-dependent driving elevated temperature environmental cue environmental cues Fever fluctuation form functional fungal fungal pathogen Gene Expression growth Heat shock highlight Host host response hosts Hsf1 Hsp90 Human impairing induce Infection mammalian mechanism microorganism microorganisms modulate molecular morphogenesis observé overexpression pathogen Pathogens physiological temperature positive provide regulate Regulation required respond survival target temperature transcription factor transcriptional tuning virulence yeast [DOI] 10.1371/journal.pgen.1007270 PMC 바로가기 [Article Type] Research Article
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated StrainArticle Published on 2016-11-292022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis Attenuated carried change Comparative diarrhea epidemic diarrhea eukaryotic expressed groups Heat shock heterogeneous immune system Infection inoculated Interaction interferon-stimulated gene involved ISGs iTRAQ Jejunum labeling Laboratory mechanism Mortality nuclear organ Pathogenesis pathogenicity PEDV Porcine epidemic diarrhea virus predominant produced Protein proteomic quantitation quantitative proteome analysis response responses responsible ribonucleoprotein Signal transduction strain Strains Stress tissue up-regulated virulent virus [DOI] 10.3390/v8120323 PMC 바로가기 [Article Type] Article
Salmonella enterica serovar Typhimurium utilizes the ClpPX and Lon proteases for optimal fitness in the ceca of chickens살모넬라 엔테리카 세로바르 타이피무리움은 닭의 맹장에서 최적의 적합성을 위해 ClpPX와 Lon 프로테아제를 이용한다.journal-article Published on 2016-07-012024-07-29 Journal: Poultry Science [Category] 살모넬라증, [키워드] CLP Heat shock Lon poultry Salmonella enterica [DOI] 10.3382/ps/pew103 [Article Type] journal-article
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article
Proteome Profile of Swine Testicular Cells Infected with Porcine Transmissible Gastroenteritis CoronavirusResearch Article Published on 2014-10-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Alpha Analysis analyzed approach biological processes caspase-8 Cell cells cellular change complex conducted coronavirus determine developmental expression expression level Extracellular matrix gastroenteritis growth growth factor Heat shock help host cell immune system Infection Interaction knowledge maturation mechanism metabolite neurological system occur Ontology Pathogenesis post infection precursor profile Protein protein complex protein level Proteins proteomic provide quantitation Quantitative Signaling significant changes in Stage Stress Testicular TGEV TGF-β1 two-dimensional viral infection virus Virus-host interactions Western blot analysis [DOI] 10.1371/journal.pone.0110647 PMC 바로가기 [Article Type] Research Article