Bromhexine Hydrochloride Tablets for the Treatment of Moderate COVID‐19: An Open‐Label Randomized Controlled Pilot StudyRandomized Controlled Trial Published on 2020-10-102022-10-04 Journal: Clinical and translational science [Category] SARS, 임상, [키워드] bromhexine Chest computed tomography Clinical efficacy clinical trial control group Controlled coronavirus disease COVID‐19 discharge rate Efficacy and safety evaluated feasibility feasible hepatic injury hydrochloride in both groups lung Mild moderate need for oxygen novel coronavirus pneumonia open‐label Patient patients with moderate pilot study Placebo plan Randomized randomly divided routine statistically significant Tablet therapy Treatment was performed [DOI] 10.1111/cts.12881 PMC 바로가기 [Article Type] Randomized Controlled Trial
A child infected with severe acute respiratory syndrome coronavirus 2 presenting with diarrhea without fever and cough A case report4400 Published on 2020-08-142022-10-30 Journal: Medicine [Category] COVID-19, MERS, [키워드] absorbed acute respiratory syndrome Admission Adults antibody Asymptomatic Atypical Case report cause causes children children with COVID-19 Chinese traditional medicine clinical feature Computed tomography computed tomography scan content coronavirus Coronavirus disease 2019 cough country COVID-19 Diagnosis diarrhea Digital discharge discharged disease epidemiological exhibited explained Fever gastroenteritis global pandemic had no hepatic injury hospital IgM and IgG lack Liver damage Liver function lung Mild nasopharyngeal swabs nucleic acid amplification nucleic acid amplification test Patient Pneumonia positive presenting pulmonary lesion pulmonary lesions SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe acute respiratory syndrome coronavirus 2 Shortness of breath spread to swab sample Symptom Symptoms the patient the SARS-CoV-2 thought Treatment virus [DOI] 10.1097/MD.0000000000021427 PMC 바로가기 [Article Type] 4400
COVID-19 and Liver Injury: A Systematic Review and Meta-AnalysisInternal Medicine Published on 2020-07-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CIs 95% confidence interval ALT Analysis articles AST baseline Bilirubin caused chi-square test chronic liver disease CIs CLD Cohort conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients database defined disease duplicate Epidemiological study estimate expected greater hepatic injury hospitalized COVID-19 patients inclusion criteria Injury limit liver abnormalities Liver damage liver enzyme liver enzymes Liver injury liver injury biomarkers material mean difference medications Meta-analysis Patient patients Prevalence proportion random-effects model required Result review SARS-CoV-2 searched severe COVID-19 severity severity of COVID-19 significantly significantly higher significantly lower standard error tested the disease transaminase virus was used with COVID-19 [DOI] 10.7759/cureus.9424 PMC 바로가기 [Article Type] Internal Medicine
Clinical Features of 33 Cases in Children Infected With SARS-CoV-2 in Anhui Province, China–A Multi-Center Retrospective Cohort Study중국 안후이성 SARS-CoV-2 감염 아동 33례의 임상적 특징–다기관 후향적 코호트 연구Public Health Published on 2020-06-162022-09-12 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, [키워드] abnormality Adults age analyzed assumed Characteristics Chest CT chest CT scan Chest CT scans children China clinical clinical feature Clinical features Clustering consolidation cough COVID-19 Dry epidemiological Familial familial clustering female patient Fever Gender GGO Ground glass opacity had more had no hepatic injury Infection Laboratory Laboratory results laboratory-confirmed SARS-CoV-2 infection lymphocyte male Mild MOST much lower nine Older older patient Patient patients patients older radiological report SARS-CoV-2 SARS-CoV-2 infections Seven suggested susceptibility Symptom Symptoms the disease their family member Treatment [DOI] 10.3389/fpubh.2020.00255 PMC 바로가기 [Article Type] Public Health
Norwegian Coronavirus Disease 2019 (NO COVID-19) Pragmatic Open label Study to assess early use of hydroxychloroquine sulphate in moderately severe hospitalised patients with coronavirus disease 2019: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-052022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 7-point ordinal scale accelerate activities activity acute respiratory syndrome adaptive addition administration Admission airway Akershus allocation sequence Analysis anticipated approach automatically baseline Biochemistry Biomarker blinded Blinding Blood C-reactive protein cardiac troponin Chloroquine clinical Clinical outcome Clinical practice clinical status clinical symptom collected condition coronavirus coronavirus disease COVID-19 Culture database Department disease dissemination early treatment element Endpoint examined excluded extracorporeal membrane oxygenation Good harmonization hepatic injury history hospital Hospital admission hospitalisation hospitalised hospitalised patient Hospitalized Hydroxychloroquine Hypothesis In-hospital include independent Inpatient intensive care intensive care unit International Conference Intervention intervention arm Invasive mechanical ventilation Laboratory marker Microbiology Mortality nasopharyngeal NEWS2 non-invasive ventilation Norway number Nurse objective open label Oropharyngeal Oropharyngeal sampling outcome oxygen participant Patient patients peptide Placebo polymerase chain polymerase chain reaction positive Practice Pragmatic pragmatic trial primary endpoint profile Prolonged Protein protocol QT interval randomisation randomised randomised controlled randomised controlled trial randomization Randomized Randomized controlled trial recruited recruitment Registered renal requiring supplemental oxygen resource responsible RT-PCR Safe Sample size SARS-CoV-2 SARS-CoV-2 viral load score secondary Seven standard care statistical analyses status Study protocol subjects Surveillance therapy transcriptase Treatment treatment allocation Trial Two-arm university use of hydroxychloroquine Viral load virological clearance viruses vital signs website [DOI] 10.1186/s13063-020-04420-0 PMC 바로가기 [Article Type] Letter
COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing LiteratureReview Published on 2020-05-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] abnormality acute respiratory syndrome alterations Anomaly Clinical course Concomitant conducted Coronaviridae coronavirus coronavirus disease COVID-19 database distress elevated evaluated Gastrointestinal symptom Gut hepatic impairment hepatic injury hepatopathy incidence infected patient Infection infections Inflammation intensive care treatment literature liver Liver injury mechanism MERS Meta-analysis Microbiome Middle East Mild Necrosis non-specific novel coronavirus SARS-CoV-2 pandemic parameters Patient patients with SARS Prevalence Prognosis Prothrombin time protocol reported review SARS SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection Science steatosis syndrome systematic literature search systematic review systemic inflammatory response Toxicity transaminases Viral hepatitis [DOI] 10.3390/jcm9051420 PMC 바로가기 [Article Type] Review
Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathwayArticle Published on 2020-05-082022-11-01 Journal: International immunopharmacology [Category] Coronavirus, [키워드] Activation alleviate anti-inflammatory agent antibody clinical setting cured cytokine deficiency disease downstream Glycyrrhetinic acid glycyrrhizic acid hepatic injury Hepatitis HMGB1 HMGB1 release human disorder hydrolysis immunological in viral Infection Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory response ingredient inhibit inhibited injection Injury involved licorice mechanism MHV mice murine murine hepatitis virus Neutralizing neutralizing antibody occur provide Regulation reported Signaling signaling pathway significantly TCM the cytokine storm therapy TLR4 Treatment triggered variety Viral hepatitis viral-induced [DOI] 10.1016/j.intimp.2020.106578 PMC 바로가기 [Article Type] Article
Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasisZebrafish slc30a10 결핍은 망간 항상성을 유지하는 Atp2c1의 새로운 보상 메커니즘을 밝혀냈습니다Research Article Published on 2017-07-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accompanied accumulated activating adulthood approach ATP2C1 ATPase Author Brain can be used characterized cirrhosis cirrhosis) clinically CRISPR deficiency degenerative degenerative diseases develop disease Disease model disorder dysregulation dystonia early-onset EDTA effective Embryo embryonic ENCODE expressing expression fibrosis form HeLa cells hepatic injury homeostasis Impaired impaired function implicated inhibit iron liver Liver fibrosis manganese manganism mechanism metabolic disorder metabolism modulating mutant mutant embryo mutant embryos mutants Mutation neurological Neurological deficit neurological deficits neurological impairment pharmacological phenotype physiological polycythemia recent reduce rescued secretory pathway Signaling significantly higher SLC30A10 specific treatment steatosis therapy underlie wild-type zebrafish [DOI] 10.1371/journal.pgen.1006892 PMC 바로가기 [Article Type] Research Article
Rodent-associated Bartonella Febrile Illness, Southwestern United StatesArticle Published on 2006-07-012023-08-30 Journal: Emerging Infectious Diseases [Category] E형 간염, [키워드] Bartonella Fever hepatic injury leukopenia liver function tests Research thrombocytopenia zoonosis [DOI] 10.3201/eid1207.040397 PMC 바로가기