The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19최신 유전자 편집 기술과 코로나19를 포함한 바이러스 감염 및 질병에 적용Review Published on 2022-06-092022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral application Biotechnology Cas9 caused combating contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic CRISPR CRISPR-Cas9 CRISPR/Cas9 diagnostic disease Disease progression Diseases domain feature gene editing Gene therapy help highlight highly pathogenic implication Including Infectious diseases mechanism Multiple pandemic pandemic disease public health SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown therapeutic therapy Vaccines viral infection virus [DOI] 10.3389/fcimb.2022.869889 PMC 바로가기 [Article Type] Review
Genome-Wide Reassortment Analysis of Influenza A H7N9 Viruses Circulating in China during 2013-2019Article Published on 2022-06-092023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] Avian influenza virus Diversity H7N9 highly pathogenic Reassortment Tanglegram. [DOI] 10.3390/v14061256 PMC 바로가기
Emerging Novel Reassortant Influenza A(H5N6) Viruses in Poultry and Humans, China, 2021Article Published on 2022-05-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] antigenic characterization Avian Influenza China highly pathogenic Influenza Novel H5N6 virus respiratory infections vaccination vaccine-preventable diseases viruses zoonoses [DOI] 10.3201/eid2805.212163 PMC 바로가기
Characterization of two chicken origin highly pathogenic H7N9 viruses isolated in northern ChinaArticle Published on 2022-05-012023-06-22 Journal: Veterinary microbiology [Category] 조류인플루엔자, [키워드] acid stability Dual-receptor characteristics H7N9 subtype avian influenza virus highly pathogenic thermal stability [DOI] 10.1016/j.vetmic.2022.109394
JMM Profile: Avian influenza: a veterinary pathogen with zoonotic potentialArticle Published on 2022-05-012023-06-22 Journal: Journal of Medical Microbiology [Category] 조류인플루엔자, [키워드] Avian Influenza highly pathogenic Low pathogenicity Safety virulence, epidemiology. [DOI] 10.1099/jmm.0.001491
Repurposing dyphylline as a pan-coronavirus antiviral therapy범 코로나 바이러스 항 바이러스 요법으로 디필린 용도 변경Article Published on 2022-05-012022-09-11 Journal: Future Medicinal Chemistry [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Alpha Antiviral antiviral agent antiviral therapy bind catalytic dyad Cell culture coronavirus COVID-19 pandemic CoVs Cystine Drug discovery dyphylline FDA-approved drug functional enzyme functional enzymes HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs highly pathogenic histidine Human human coronavirus human coronaviruses human coronaviruses (HCoVs) humans inhibited life cycle Mild MPro NL63 OC43 protease repurposing respiratory diseases SARS-CoV-2 severe respiratory disease severe respiratory diseases structures Support targets therapeutically target viral replication Virtual screening virus Virus life cycle viruses xanthine zoonotic [DOI] 10.4155/fmc-2021-0311 PMC 바로가기 [Article Type] Article
Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replicationSARS-CoV-2에 대한 기도 상피 인터페론 반응은 리노바이러스보다 열등하고 이종 라이노바이러스 감염은 SARS-CoV-2 복제를 억제합니다Article Published on 2022-04-282022-09-11 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] addition AEC airway airway epithelial cell airway epithelial cells airway epithelium alphacoronavirus Betacoronavirus biosafety level Biosafety Level 3 bronchial BSL-3 cell lysate cell lysates children common Concentration correlated Culture cultures CXCL10 Delta delta variant Donor elicit epithelial epithelial cells evade Ex vivo experiment Gene Expression generate greater heterogeneity Heterologous highly pathogenic HRV IFN IFN response IFN-β IFN-λ IFNB1 induce Infection interferon interferon response less level 3 Older omicron Protein recombinant IFN recombinant IFN-β reduce reduced replicated response responses rhinovirus RNA robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly subset supernatant suppresse Treatment type I variant variants viral replication was collected were infected [DOI] 10.1038/s41598-022-10763-2 PMC 바로가기 [Article Type] Article
Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology ApproachMERS, SARS-CoV 및 SARS-CoV-2에 대한 계산적으로 설계된 mRNA 및 펩티드 기반 예방 백신의 잠재적 면역원 활성: 역백신학 접근Article Published on 2022-04-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure activity acute respiratory syndrome coronavirus antiviral therapeutics B-cells binding coronavirus Coronavirus-2 Coronaviruses cross-protective CTL CTLs cytotoxic cytotoxic T lymphocytes develop effective Efficacy epitope Epitope-based vaccine Epitopes evaluated followed by HCoVs helper highly pathogenic HTL epitope HTL epitopes HTLs human coronavirus human coronaviruses humans Immune simulation immunogenic immunogenic activity imperative lethality MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular docking mRNA mRNA-based offer pandemic pathogenic coronaviruses peptide Potential predicted processed Prophylactic prophylactic vaccine. proteomic RBDs receptor-binding domains respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 similarity the receptor-binding domain these viruses TLR4 Vaccine Vaccine design viruses [DOI] 10.3390/molecules27072375 PMC 바로가기 [Article Type] Article
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody Antibody Response caused circulating variants concerning contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-convalescent individual COVID-19-convalescent individuals cytokine cytokine production diagnostic disease onset dissect dominant dominant epitope early stage early stages endemic human coronavirus endemic human coronaviruses epitope Epitopes fatality feature global pandemic highly pathogenic humoral humoral immune responses Humoral immunity immune immune profiling immune response immune responses Immunity individual induce Kinetics long-term immune response long-term immune responses Longevity longitudinal longitudinal analysis mapped moderate moderate symptoms N-terminal domain Neutralizing antibodies neutralizing antibody ORF1ab path patients peptide peptide microarray performed Protein Proteins proteome proteome-wide peptide microarray. reactive respiratory responsible reveal S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein sequence homology sequence identity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specific antibodies Spike protein sustained symptoms of COVID-19 the early SARS-CoV-2 the S1 subunit the SARS-CoV-2 Vaccine design Wuhan-Hu-1 [DOI] 10.1016/j.jaci.2022.01.005 PMC 바로가기 [Article Type] Article
MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunityArticle Published on 2022-03-252022-11-01 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] accessory protein adapter Alter binding binding domain binding mechanism biochemically canonical coronavirus Edward explain high-resolution structure highly pathogenic Host Immunity impair infected cells inhibiting innate immune innate immune response innate immune responses Innate immunity Interaction lack mechanism MERS coronavirus MERS-CoV Mutation NF-κB NLS nuclear nuclear translocation ORF4b overlap P50 Protein shown signaling pathways Structure viral infection virus Virus-host interactions X-ray crystallography [DOI] 10.1038/s41467-022-28851-2 PMC 바로가기 [Article Type] Article