Evolution of pathological findings in surveillance biopsies of lung transplant recipients infected with SARS-CoV-2SARS-CoV-2에 감염된 폐 이식 수혜자의 감시 생검에서 병리학적 소견의 진화Article Published on 2022-06-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Admission alteration biopsy Bronchiolitis bronchiolitis obliterans case sery coronavirus disease Coronavirus disease 2019 COVID-19 described determine Diagnosis died Evolution Follow-up GRADE heart histology Hospitalized ICU immunofluorescence inclusion criteria infected with SARS-CoV-2 intensive care intensive care unit large cohort lung Lung injury lung transplant lung transplantation non-transplant patient non-transplant patients one patient Organizing pneumonia outcome outcomes pathologic pathological finding pathology Patient positive Prognosis Protein recipient recipients rejection respiratory pathogen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid Society specimen subset Surveillance Symptomatic patients tested transbronchial Transplant Two patient two patients was performed [DOI] 10.1111/tid.13823 PMC 바로가기 [Article Type] Article
C57BL/6J Mice Are Not Suitable for Modeling Severe SARS-CoV-2 Beta and Gamma Variant InfectionC57BL/6J 마우스는 심각한 SARS-CoV-2 베타 및 감마 변종 감염을 모델링하는 데 적합하지 않습니다.Article Published on 2022-05-052022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Alpha angiotensin Angiotensin converting enzyme-2 ARDS B.1.1.7 B.1.351 B.1.617.2 Beta body weight Body Weight Changes C57BL/6 CCR2 change changes clinical disease deficiency Delta entry of SARS-CoV-2 eosin Evidence evidence of examined expression Gamma H&E H&E staining hACE2 hACE2 receptor hematoxylin histology IHC IHC staining immune immune deficiency Immunocompromised immunocompromised mice immunohistochemistry indicated infect Infection lung Lung pathology mice modeling Mutation P.1 pathologic pathological change pathological changes Probability qPCR RAG2 receptor replicate required SARS-CoV-2 SARS-CoV-2 variants severe COVID-19 shown staining survival These data three group three groups transgenic mice Transmissibility variant variants variants of concern variants of SARS-CoV-2 Viral antigen Viral protein viral titer virulence VoC VOCs weight loss were used [DOI] 10.3390/v14050966 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of HamstersArticle Published on 2022-05-042023-06-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, [키워드] cilia COVID-19 golden Syrian hamster histology immunohistochemistry respiratory epithelium SARS-CoV-2 scanning electron microscopy Trachea transmission electron microscopy [DOI] 10.3390/ijms23095124 PMC 바로가기 [Article Type] Article
Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature무증상 여성의 임신 2기 쌍둥이 사산에서 SARS-CoV-2의 수직 전파 및 간질성 폐렴의 증거. 사례 보고 및 문헌 검토Review Published on 2022-05-012022-09-11 Journal: American journal of obstetrics & gynecology MFM [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence Asymptomatic Autopsy chorioamnionitis COVID-19 demonstrated described evidence of fetal histology immunohistochemistry in utero Infants Infection interstitial pneumonia lead marker morbidity Patient placental Pregnancy pregnant women respiratory SARS-COV-2 infection second trimester Stillbirth stillborn syncytiotrophoblast syndrome Transmission transmission of SARS-CoV-2 transmission rate vertical transmission woman [DOI] 10.1016/j.ajogmf.2022.100589 PMC 바로가기 [Article Type] Review
Morphological and Immunopathological Aspects of Lingual Tissues in COVID-19COVID-19에서 혀 조직의 형태학적 및 면역병리학적 측면Article Published on 2022-04-062022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] ACE2 alteration aspect association cadaver caused circumvallate papillae COVID-19 destruction detect detectable died disease disorder downregulated evidenced factor VIII filiform histological analysis histology IFN-γ immunopathological Inflammation Inflammatory lingual lingual papillae loss of taste manifestation molecular analysis Morphological no difference no differences oral manifestations Patient positive processed provided real-time RT-PCR RT-PCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe inflammation severity Signs and symptoms subject Symptom Symptoms Taste taste buds the disease tissue tongue tongue. two groups variety virus [DOI] 10.3390/cells11071248 PMC 바로가기 [Article Type] Article
Inhalation of nebulized omega-3 fatty acids mitigate LPS-induced acute lung inflammation in rats: Implications for treatment of COPD and COVID-19Research article Published on 2022-04-012022-10-05 Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids [Category] 치료법, [키워드] acute lung inflammation acute respiratory distress Administered alveolar Anti-inflammatory Antithrombotic Asthma Budesonide cannabidiol chronic obstructive COPD COVID-19 cytokine determine distress docosahexaenoic acid (DHA) Docosapentaenoic acid (DPA) effective Effects Eicosapentaenoic acid (EPA) Fatty acid free fatty acid group groups histology IL-10 IL-1β IL-6 inhalation injection intravenous investigated less LPS lung cancer lung disorders Lung inflammation male mitigate Montelukast nebulized no evidence of omega-3 Omega-3 fatty acids Pneumonia preclinical data pulmonary disease Severity Score Side effects TGF-β the disease thrombosis TNF-α treated Treatment triggered [DOI] 10.1016/j.plefa.2022.102426 [Article Type] Research article
Anxiety and depression in patients with advanced cancer during the COVID-19 pandemicCOVID-19 전염병 동안 진행된 암 환자의 불안과 우울증Multicenter Study Published on 2022-04-012022-09-11 Journal: Supportive Care in Cancer [Category] COVID19(2023년), SARS, 치료기술, [키워드] Advanced cancer age Anxiety association Cancer Cancer patients cancer type children clinical variables Cohort consecutive patient COVID-19 COVID-19 pandemic Depression diagnosed Diagnosis distress early diagnosis Effect emotional distress Factor female greater higher risk histology Hope hopelessness Hopelessness. illness incidence increased risk index initiated Intervention inventory linear regression analyses Linear regression analysis marital status multicenter no differences pandemic Patient Psychological psychological factors regression analysis scale Sociodemographic Stage subgroups survival Treatment Uncertainty women Worry [DOI] 10.1007/s00520-021-06789-3 PMC 바로가기 [Article Type] Multicenter Study
A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer Research Published on 2022-03-152022-10-05 Journal: Prostate cancer and prostatic diseases [Category] 바이오마커, 임상, [키워드] 95% CI Activation Administered anticipated Avelumab Central nervous system Complete conducted COVID-19 COVID-19 pandemic criteria CXCR2 defined disease Efficacy Endpoint enrolled Enrollment histology immune Immune cell Immunotherapy liver median median age men Metastasis monotherapy Msh2 Mutation neuroendocrine open label Patient patients PD-L1 Peripheral blood phase 2 trial Phenotyping poor prognosis positive potential mechanism primary endpoint progression progressive disease Prostate cancer Radiographic Result Safety secondary single center subset survival T-cell Response tested therapy Toxicity Treatment while [DOI] 10.1038/s41391-022-00524-7 [Article Type] Research
Clinicopathologic characteristics of severe COVID-19 patients in Mexico City: A post-mortem analysis using a minimally invasive autopsy approachResearch Article Published on 2022-03-032022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] alteration Analysis approach Autopsies Autopsy Characteristics characterized Clinical finding cohort study cohorts correlation COVID-19 Deceased demonstrated described diagnosis of SARS-CoV-2 diagnostic Diffuse alveolar damage Endothelitis feature hallmark hepatic histologic histological histology Histopathology Inflammation Injury Interstitial nephritis invasive kidney Liver function Liver histology liver tissue lung Lung compliance mechanical ventilation Mexico City Necrosis neutrophilic objective Patient performed Pneumonia Post-mortem predominant reported Result SARS-CoV-2 positivity setting severe COVID-19 patient severe SARS-CoV-2 steatosis the disease thrombosis [DOI] 10.1371/journal.pone.0262783 PMC 바로가기 [Article Type] Research Article
Intrauterine Fetal Demise in the Third Trimester of Pregnancy Associated With Mild Infection With the SARS-CoV-2 Delta Variant Without Protection From Vaccination예방 접종을 받지 않은 SARS-CoV-2 Delta 변이체의 경증 감염과 관련된 임신 3분기의 자궁 내 태아 사망Article Published on 2022-03-022022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adults coronavirus COVID-19 Delta delta variant demise elevated fetal histology Infection infection rate intrauterine fetal demise Mild symptom mild symptoms morbidity and mortality Placenta placental predominant Pregnancy pregnant women Proinflammatory response protection reduce risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 the SARS-CoV-2 Transmissibility trimester women [DOI] 10.1093/infdis/jiac007 PMC 바로가기 [Article Type] Article