Post-mortem histopathology of pituitary and adrenals of COVID-19 patientsCOVID-19 환자의 뇌하수체 및 부신의 사후 조직 병리학Article Published on 2022-07-012022-09-11 Journal: Legal medicine (Tokyo, Japan) [Category] 치료기술, 치료법, [키워드] addition Adrenal adrenal gland adrenals analyzed antibody Cell changes in cortical Course COVID-19 COVID-19 infection COVID-19 patient Evidence evidence of examined formalin histopathological Histopathology increase in independent of Infection lymphoma Necrosis no evidence of nodule nucleocapsid organ PAS performed Pituitary pituitary gland Pituitary. predominant Shock staining Stress stress response T-cell T-Cell Lymphoma tissue [DOI] 10.1016/j.legalmed.2022.102045 PMC 바로가기 [Article Type] Article
Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic micehACE2 형질전환 마우스에서 SARS-CoV-2 감염 후 시간적 뇌 병변Article Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis animal model astrogliosis Beta Brain cause Central nervous system Cerebellum characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop different time points distribution Encephalitis hACE2 hACE2-transgenic mice histopathological immunohistochemistry immunolabeling inoculation lesion meningoencephalitis mice mucosa necropsies necropsy Neuroinflammation Neurological disease neuronal neurons Neuropathology nonsuppurative olfactory other organ other organs panel of antibodies panel of antibody performed post inoculation processed question reached Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spongiosis Spread susceptible thrombosis transgenic mice vacuolar vacuolar degeneration variants Vasculitis virological assay virological assays virus [DOI] 10.1177/03009858211066841 PMC 바로가기 [Article Type] Article
Pyo pneumothorax revealing splenic tuberculosis abscess in a COVID-19 femmal: A case reportCase report Published on 2022-07-012022-10-05 Journal: International Journal of Surgery Case Reports [Category] 진단, [키워드] Analysis Case report characteristic Co-infection Complication complications Computed tomography COVID-19 CTComputed Tomography Diagnosis diagnostic Emergency surgery Evolution exceptional female histopathological intrapleural life-threatening medications more difficult Patient positive presentation regimen reported rupture Splenic splenic abscess Splenic tuberculosis STSplenic tuberculosis Symptom Symptoms TBTuberculosis therapeutic Tuberculosis was performed with COVID-19 [DOI] 10.1016/j.ijscr.2022.107312 [Article Type] Case report
Complement activation in COVID-19 and targeted therapeutic options: A scoping reviewReview article Published on 2022-07-012022-10-05 Journal: Blood reviews [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] Activation approach article C5a complement Complement activation Complement cascade complement inhibition Complement pathway Coronavirus disease 2019 correlation COVID-19 disease severity double blind Evidence histopathological Increasing Mortality observational study Pathogenesis RCT review SARS-CoV-2 screened therapeutic [DOI] 10.1016/j.blre.2022.100995 [Article Type] Review article
Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case SeriesCOVID-19 백신 접종 후 심근내 염증: 심근내막 생검으로 입증된 사례 시리즈Article Published on 2022-06-222022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] administration Analysis can not Cardiomyopathy Case report causal relationship cause CD4 CD8 Cell clinical suspicion Comirnaty connection COVID-19 COVID-19 vaccination criteria demonstrated Diagnosis Differential analysis dominance Ejection fraction EMB Endomyocardial biopsy epidemiological excluded expression of SARS-CoV-2 Giant giant cell giant cell myocarditis heart histopathological increased risk individual infectious Inflammatory inflammatory cardiomyopathy Inflammatory marker inflammatory markers Inflammatory response investigated janssen Johnson & Johnson LVEF male mRNA mRNA-based vaccines Myocardial inflammation myocarditis nine Occurrence Patient patients Pfizer-BioNTech reduced reported SARS-CoV-2 SARS-CoV-2 spike protein Sery Spike protein T cell T cells the vaccine triggered vaccination Vaxzevria [DOI] 10.3390/ijms23136940 PMC 바로가기 [Article Type] Article
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model코로나바이러스 질환 2019(COVID-19) mRNA 백신의 정맥 주사가 마우스 모델에서 급성 심근염을 유발할 수 있음Article Published on 2022-06-102022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome antigen expression Apoptosis Ballooning degeneration Blood Can cardiac Cardiac pathology change changes clinical manifestations coronavirus coronavirus disease COVID-19 COVID-19 mRNA vaccine different time point dose Evidence evidenced hepatocyte histological change histopathological IL-6 immunization immunostaining in vivo induce infiltrating immune cell inflammatory cell infiltration injection interferon intracardiac intramuscular intravenous Intravenous injection Messenger RNA mice Model mouse mouse model mRNA mRNA expression mRNA vaccine myocytes Myopericarditis Necrosis other organ provided reduce reported risk SARS-CoV-2 serum Serum level significantly significantly higher skeletal tissue Vaccine vaccine injection Vaccines vascular endothelial cells visceral weight loss Withdrawal [DOI] 10.1093/cid/ciab707 PMC 바로가기 [Article Type] Article
Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19치명적인 COVID-19에서 연령 관련 위험 및 폐포 손상의 면역 및 상피 결정인자Article Published on 2022-06-082022-09-12 Journal: JCI Insight [Category] MERS, 진단, [키워드] acute lung injury age aging alveolar alveolar injury Autopsy CD4+ CD8+ T cell Cell characterized contribute correlated COVID-19 cytotoxicity deficiency determinant Donor donors dysfunction early stage epithelial expressed fatal COVID-19 Gas exchange histopathological Immune cell increasing age individuals Infection lung lung damage Lung injury lymphocyte Macrophage Macrophage infiltration macrophages Older organ pathological stage performed pulmonary Pulmonary surfactants respiratory risk susceptibility T cell activation T cells underlie uninfected widespread [DOI] 10.1172/jci.insight.157608 PMC 바로가기 [Article Type] Article
Stillbirth due to SARS-CoV-2 placentitis without evidence of intrauterine transmission to fetus: association with maternal risk factors태아에 대한 자궁내 전파의 증거가 없는 SARS-CoV-2 태반염으로 인한 사산: 산모 위험 인자와의 연관성Multicenter Study Published on 2022-06-012022-09-11 Journal: Ultrasound in obstetrics & gynecology : the offici [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected affecting Analysis asphyctic association Asymptomatic Autopsy carried caused Chain Reaction characterized Clinical characteristics Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis death demise diagnosed electron microscopy Evidence evidence of examined Factor Factors fetal fetal death fetal infection fetus FGR Greece Gross growth Gynecology histological histological change histopathological identify immunostaining independent Infection Inflammatory intervillous space intrauterine fetal death lesion less live birth Microscopy mild clinical symptom mild clinical symptoms molecular mother multicenter Multiple multiple sclerosis Neonates no evidence of obstetrics occurred organs pathology Placenta placental Placentas placentitis polymerase chain polymerase chain reaction positive potential risk predisposing factors pregnancies Pregnancy pregnant women prenatally ranged Regression regression analysis respiratory retrieved risk risk factor Risk factors SARS-CoV-2 SARS-CoV-2 placentitis SARS-CoV-2 spike protein Seven severe acute respiratory syndrome Coronavirus Society Spike protein Stillbirth stillborn Thrombophilia tissues Transmission Ultrasound Viral Viral transmission virion virions was performed was used [DOI] 10.1002/uog.24906 PMC 바로가기 [Article Type] Multicenter Study
Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer’s disease Research Published on 2022-05-112022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Affect age alteration Alzheimer’s disease animal model baseline Biomarker Brain buffer change characterized comparable comparison detect determine develop dimension disease dysfunction early stage Effect facilitated Factor Fractal Genotype histopathological increase in indicated injected injection Interaction lack linear longitudinal majority mice neurodegenerative outcomes pathological change Pathologies pathology performed plaque quantified reduction returned statistically the disease wild-type [DOI] 10.1038/s41598-022-11582-1 [Article Type] Research
Preclinical Assessment of IgY Antibodies Against Recombinant SARS-CoV-2 RBD Protein for Prophylaxis and Post-Infection Treatment of COVID-19COVID-19의 예방 및 감염 후 치료를 위한 재조합 SARS-CoV-2 RBD 단백질에 대한 IgY 항체의 전임상 평가Article Published on 2022-05-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administration Against antibody approach assessment COVID-19 COVID-19 infection COVID-19 pandemic death demonstrated develop Efficacy egg-yolk antibodies hamster histopathological IgY immunoreactivity infected patients intranasally Mortality neutralization outbreak pandemic passive immunity passive immunization performed Post-infection Preclinical produced prophylactic treatment protective effect purified Receptor binding domain recombinant recombinant RBD protein Safety SARS-CoV-2 SARS-CoV-2 RBD therapy Treatment Vaccine was tested [DOI] 10.3389/fimmu.2022.881604 PMC 바로가기 [Article Type] Article