Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose마이코박테리아의 세포 외피 스트레스는 트레할로스에 대한 반응으로 새로운 신호 전달 ATPase IniR에 의해 조절됩니다Research Article Published on 2017-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activator Affect assembly ATPase Author BAC bacterial cell biogenesis cascade Cell cell envelope cell wall complex compounds damaged defect domain domains drug ethambutol experiment explain exposure to family Gram-negative bacteria homologue identify include induce inducer integrity involved isoniazid latter gene Lipid lipids locus mechanism Mutagenesis mutant mutants mutations mycobacteria mycobacterial Mycobacterium operon overexpression pathway promoter PROTECT regulated Regulation regulator Regulatory regulatory gene respond RNAseq shown signal Signal transduction Signaling Stress stress response sugar sugars the cell transcriptional regulator transposon trehalose Tuberculosis understanding unique [DOI] 10.1371/journal.pgen.1007131 PMC 바로가기 [Article Type] Research Article
Evidence for the evolutionary steps leading to mecA -mediated β-lactam resistance in staphylococci포도상구균에서 mecA 매개 β-락탐 내성으로 이어지는 진화 단계에 대한 증거Research Article Published on 2017-04-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation acquisition adaptation Amino acid Analysis antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial Bayesian analysis binding binding domain cell wall cell wall synthesis changes in chromosome Community core genome development domain driving epidemiologically Evolution exposure to food additives gene encoding Genetic genetic background genomes highlight homologue identify involved isolates livestock mechanism mechanisms methicillin methicillin-resistant Staphylococcus aureus Mortality MRSA mutation rate Mutation rates non-binding nucleotide occur occurred oxacillin Pandemics PBP penicillin phenotype Phylogenetic analysis precursor predicted profiles promoter promoters Protein representing resistance gene resource responsible S . aureus SCC selective sequence sequence alignments sequenced genome single-nucleotide polymorphism SNP species Spread Staphylococcus Staphylococcus aureus strain Substitution substitutions susceptibility variety was performed [DOI] 10.1371/journal.pgen.1006674 PMC 바로가기 [Article Type] Research Article
Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns완전한 치킨 BG 일배체형의 시퀀스는 특정 발현 패턴을 가진 두 유전자 계통의 동적 확장 및 수축을 보여줍니다Research Article Published on 2014-06-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin allelic Antigen presentation appear association Autoimmune disease Autoimmune diseases B12 brush border Cell cells change chicken chromosome chromosome 2 CNV complex contraction copy number Deletion domain dynamic Evolution expansion expressed expression family fixed Genes genetic association genetic associations Haplotype haplotypes homolog homologue homologues Human humans identify immune immune gene immune genes Immunity implicated Interaction intestinal involved major histocompatibility complex mammal mammals MHC multigene families multigene family myosin Particular pathogen Pathogens pattern polymorphism promoter promoters Recombination Region scrutiny sequence show single gene species tandem repeats the major histocompatibility tissue tissue expression tissues undergo untranslated regions Variation Viral diseases whole genome [DOI] 10.1371/journal.pgen.1004417 PMC 바로가기 [Article Type] Research Article
The Transcription Factor BcLTF1 Regulates Virulence and Light Responses in the Necrotrophic Plant Pathogen Botrytis cinerea전사 인자 BcLTF1은 괴사성 식물 병원체 Botrytis cinerea에서 독성과 빛 반응을 조절합니다Research Article Published on 2014-01-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulation addition Affect alternative oxidase alternative respiration enzymes antioxidants AOX apothecia applied approach arising Aspergillus nidulan Aspergillus nidulans Author BcLTF1 bctlf1 Botrytis cinerea caused characterized circadian rhythm conditions conidia continuous light Deletion dependent on detoxification detrimental effect detrimental effects dicotyledonous plant differentiation dispersal ecological ecological niche equilibrium Evidence exogenously exposure to expression expression level expression levels expression of gene Factor fertilization filamentous fungi fruiting bodies function fungal fungal pathogen fungi fungus GATA transcription factor Gene gene encoding Genes gray mold disease gray mold diseases growth rate growth rates homoeostasis homologue Host host infection hypersensitivity illumination impair Increased increased expression induce Infection LIGHT macroconidia macromolecule macromolecules majority metabolism Microarray analyses microarray analysis microconidia mitochondrial mitochondrial dysfunction modulated mutant mutants necrotrophic pathogen necrotrophic pathogen Botrytis cinerea Neurospora crassa NsdD Organisms Orientation over-expression overexpression oxidative stress oxygen Pathogens photomorphogenesis photoreceptor phototropism pigments plant plants predicted propagule propagules PROTECT random mutagenesis reactive oxygen species reactive oxygen specy Regulation reproductive required respiration enzymes respond response restoration ROS scavenging sclerotia Secondary metabolism sexual reproduction singlet oxygen spores Structure structures SUB-1 survival TF 1 transcription factor transcriptional level virulence [DOI] 10.1371/journal.pgen.1004040 PMC 바로가기 [Article Type] Research Article
Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen정량적 유전 발자국과 특성 강화 분석을 결합하여 세균성 병원체의 적합성 결정 요인 식별Research Article Published on 2013-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major abundance Affect Algorithm Antibiotic resistance approach approaches array assortment Author Bacterial bacterial gene bacterial genes benefit bioinformatics candidate gene changes in Combination conjunction conserved dataset deep sequencing deleted determinant determinants Determining diagnostic dissect Diversity DNA binding E. coli effective effort enrichment Escherichia Escherichia coli Factor fitness Follow-up analysis Footprinting found Gene Genes Genetic Genome genomes highest highlight homologue homologues Host hypothetical identify increasingly independent Infection infections insertion investigator investigators isolates Meningitis molecular mouse model Mutagenesis mutant novel observation observations pathogen Pathogenesis pathogenic pathogenic strain pathogenic strains Pathogens phenotypic phenotypic variation phylogenetic distribution promote Quantitative reported required Research resource saturated Sepsis Sequencing shown strain Strains suggested therapeutic therapeutic targets Therapies Tn-seq to define trait transcriptional repressor transposon urinary tract infections variant Variation virulence virulence gene widespread zebrafish [DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article
Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genesResearch Published on 2006-12-282022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] 229E Accessory genes Amino acid amino acids Analysis analyzed CCU Cell culture Cold collected common conserved coronavirus coronavirus 229E determine ENCODE envelope gene FIVE Genes Genome genome organization HCoV-229E HCoV-NL63 homologue Human in vivo isolate Laboratory Netherland nucleotide ORF ORF3 protein ORF4b PEDV Protein Proteins prototype virus related Result sequence unit [DOI] 10.1186/1743-422X-3-106 PMC 바로가기 [Article Type] Research
The Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike proteinHypothesis Published on 2005-02-102022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition biochemically Cell Coronaviruses cytoplasmic cytoplasmic tail decrease different domain Effect examined expressed expression genetics Genome homologue Hypothesis Impact in vitro in vivo infected cell Infection Interaction mechanism methodology modulate motif Open reading frame other coronaviruses pathway presentation Protein Replication reported respiratory resulting RNA SARS-CoV severe shown significantly Spike protein Testing the spike protein undergo unique viral infection viral pathogenesis Viral protein viral spread [DOI] 10.1186/1743-422X-2-5 PMC 바로가기 [Article Type] Hypothesis