Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registryArticle Published on 2022-09-012022-11-15 Journal: RMD Open [Category] 진단, [키워드] 95% CI addition age Alliance Analysis association Clinical characteristics Comorbidity COVID-19 COVID-19 diagnosis COVID-19 severity death demographic dermatomyositis died Disease activity dose drug Epidemiology Factor female Health hospitalisation hospitalised Inflammatory less Male sex management multivariable not significant ordinal logistic regression outcome outcome assessment, health care outcomes oxygen Patient patients performed polymyositis registry data risk stratification Sensitivity analyses severe COVID-19 severity significantly variables [DOI] 10.1136/rmdopen-2022-002508 PMC 바로가기
Troponin and short-term mortality in hospitalised patients with COVID-19 infection: a retrospective study in an inner-city London hospitalObservational Study Published on 2022-08-242022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] 95% CI age analysed association biochemical Cardiology collected COVID-19 death defined demonstrated East evaluate females hospital Hospital admission hospitalised hospitalised patient increased mortality independent Laboratory limit Local London Lung disease males men Mortality Patient patients with COVID-19 performed positive positive airway pressure Primary outcome public health regression analysis retrospective Retrospective study RT-PCR sensitivity significantly significantly higher specificity survival the patient troponin university with COVID-19 women [DOI] 10.1136/bmjopen-2022-061426 PMC 바로가기 [Article Type] Observational Study
Early oral antiviral use in patients hospitalised with COVID-19Discussion Published on 2022-08-242022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral hospitalised Patient with COVID-19 [DOI] 10.1016/S1473-3099(22)00522-9 [Article Type] Discussion
Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong’s omicron BA.2 wave: a retrospective cohort studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 1:1 Abstract Admission all-cause mortality analysed Antiviral Antiviral treatment authority calculated Chinese clinical benefit contraindication Control controls COVID-19 COVID-19 diagnosis Cox regression models Cycle threshold value Department diagnosis of SARS-CoV-2 Disease progression Effectiveness eligible evaluate event exclusion finding Follow-up for inclusion funding hazard ratio Hong Kong hospital hospitalised hospitalised patient HRs ICU admission IMV incidence rate Infection intensive care Invasive mechanical ventilation lower risk material Mild-to-moderate molnupiravir need for oxygen oral outcome outcomes Oxygen therapy pandemic Patient patients Primary outcome recipient Region registry renal required retrospective cohort retrospective cohort study RT-PCR SARS-CoV-2 SARS-COV-2 infection secondary outcome severe liver impairment Significant significantly shorter study period supplemental oxygen Support symptom onset therapy time translation viral burden virological outcome were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00507-2 [Article Type] Research article
Overweight and obesity are not associated with worse clinical outcomes in COVID-19 patients treated with fixed-dose 6 mg dexamethasone Research Published on 2022-08-192022-10-05 Journal: International journal of obesity (2005) [Category] 임상, 치료법, [키워드] adjusted Admission age Analysis association BMI body mass index Clinical course Clinical outcome clinical outcomes Cohort cohort of patient cohorts Comorbidities conducted COVID-19 patient CRP level death defined Dexamethasone dose fixed hospital hospitalised hospitalised COVID-19 patient ICU admission inflammatory status introduced Lymphocyte count multivariable analyses multivariable logistic regression non-ICU obesity objective opposite overweight Oxygen requirement Patient patients treated patients with obesity percentage pharmacokinetic prevalent repeated Result retrospective cohort study standard treatment supplemental oxygen translate treated [DOI] 10.1038/s41366-022-01204-1 [Article Type] Research
Using patient biomarker time series to determine mortality risk in hospitalised COVID-19 patients: A comparative analysis across two New York hospitals입원한 COVID-19 환자의 사망 위험을 결정하기 위해 환자 바이오마커 시계열을 사용: 두 뉴욕 병원에 대한 비교 분석Article Published on 2022-08-182022-09-11 Journal: PLoS ONE [Category] SARS, 바이오마커, 치료기술, [키워드] Accuracy Admission Analysis Bayesian Biomarker Biomarkers center changes in clinical measurement cohorts COVID-19 COVID-19 patient death determine died difficulty discharge discharged explain Factor focus generalisability Health Sciences high risk high risk patients highlight hospital hospitalisation hospitalised hospitals Maimonide Maimonides Markov median Model Mortality mortality risk New New York outcome Patient patient cohort patient cohorts patient mortality patients Predictive prognostic model Prognostic models question raising restrict risk risk of COVID-19 Science sensitivity single hospital state tested university utility variables [DOI] 10.1371/journal.pone.0272442 PMC 바로가기 [Article Type] Article
A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial – implications for therapeutic immune modulationResearch article Published on 2022-08-182022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 변종, 임상, [키워드] 1:1 Activation Adaptive immune response addition adverse event ARCADIA assigned AZD1656 Clinical improvement clinical trial Complete COVID-19 cytokine Czech Republic Day death decrease diabetes diabetic patient diabetic patients dose double-blind duration of hospitalisation Efficacy Excalibur False positive finding Full Analysis Set funding Glucokinase activator group homeostatic hospital hospital discharge hospitalised identify immune Immune cell immune modulation immune response Immunochemistry immunomodulatory effect Immunophenotyping implication indicated Innovation investigated involved less Medicine multicentre nine no difference Patient phase Phase 2 Placebo placebo-controlled placebo-controlled clinical trial primary analysis primary endpoint pro-inflammatory randomised Randomly receive recruited reduction in Registered regulatory T cells required risk Romania SARS-CoV-2 screened statistically significant difference suggested Tablet the placebo group therapeutic therapeutic effect treated Treatment treatment allocation Tregs Trial usual care with COVID-19 [DOI] 10.1016/j.eclinm.2022.101604 [Article Type] Research article
Trends in COVID-19 hospital outcomes in England before and after vaccine introduction, a cohort study Research Published on 2022-08-172022-10-05 Journal: Nature Communications [Category] SARS, 치료법, [키워드] 95% confidence interval Admission changed co-morbidity cohort study COVID-19 COVID-19 cases demographic factor discharge England estimate fatality hospital hospital resources hospitalised individual morbidity and mortality Mortality outcome outcomes pandemic Prognosis ranged reducing risk Symptom trend vaccination Vaccine vaccine dose with COVID-19 [DOI] 10.1038/s41467-022-32458-y [Article Type] Research
Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21Randomized Controlled Trial Published on 2022-08-152022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] Admission breathlessness cause chest pain Contact Controlled clinical trial COVID COVID-19 COVID-19 infection diagnosis of COVID-19 discharged Dyspnoea early treatment Effect Ethical approval ethics committee Exercise capacity fatigue frailty group Health Health status healthcare professionals hospital hospitalisation hospitalised Infection Intervention Long Long COVID National Health Service NHS participant Patient personalised physical physical activity Pragmatic prevention Primary outcome problem Quality of life questionnaire randomisation randomised randomised controlled trial REC recruitment Registered rehabilitation resistance resistance exercise SARS-CoV-2 secondary outcome spirometry Symptom syndrome therapy Two-arm usual care West [DOI] 10.1186/s13063-022-06632-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Update June 2022: management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline2022년 6월 업데이트: 코로나바이러스 질병 2019(COVID-19)로 입원한 성인 관리: 유럽 호흡기 학회 생활 지침Editorial Published on 2022-08-102022-09-11 Journal: The European Respiratory Journal [Category] Fulltext, SARS, 바이오마커, [키워드] anti-IL-6 anticoagulation Baricitinib coronavirus disease Corticosteroids COVID-19 guideline European hospitalised hospitalised patient Hospitalised patients management monoclonal antibodies Non-invasive respiratory support recommendation respiratory Society with COVID-19 [DOI] 10.1183/13993003.00803-2022 PMC 바로가기 [Article Type] Editorial