host-pathogen interaction – Page 3 – Communicable Diseases Research

Host metabolic reprogramming in response to SARS-CoV-2 infection: A systems biology approach

SARS-CoV-2 감염에 대한 숙주 대사 재프로그래밍: 시스템 생물학 접근법

Article

Published on 2021-09-012022-09-11
Journal: Microbial pathogenesis [Category] SARS, 신약개발, 유전자 메커니즘,

Lewis and ABO histo-blood types and the secretor status of patients hospitalized with COVID-19 implicate a role for ABO antibodies in susceptibility to infection with SARS-CoV-2

루이스 및 ABO 조직 혈액형 및 COVID-19로 입원한 환자의 분비 상태는 SARS-CoV-2 감염에 대한 감수성에서 ABO 항체의 역할을 암시합니다

Article

Published on 2021-09-012022-09-12
Journal: Transfusion [Category] MERS, SARS, 진단,

[키워드] ABO acute respiratory syndrome addressed analyzed antibody Antigen antigen expression association Blood blood donor Blood Group blood type Caucasians Clinical outcome Cohort confidence interval controls coronavirus coronavirus disease COVID-19 Deceased defined disease severity Factors FUT2 FUT3 genotyped Hospitalized host susceptibility host-pathogen interaction individual Infection infection with SARS-CoV-2 infections intensive care intubation investigated less Lewis Odds ratio Patient patients patients hospitalized prevalent prognostic proportion Protective risk factor SARS-CoV-2 SARS-COV-2 infection secretor. severity of COVID-19 significantly significantly more subsequent analyses suggested susceptibility target the patient Variation with COVID-19
[DOI] 10.1111/trf.16567 PMC 바로가기 [Article Type] Article

Network-Based Analysis of Fatal Comorbidities of COVID-19 and Potential Therapeutics

COVID-19 및 잠재적 치료제의 치명적인 동반 질환에 대한 네트워크 기반 분석

Article

Published on 2021-07-012022-09-11
Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 신약개발, 치료제,

[키워드] ACE2 acute lung injury acute respiratory distress acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aging angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 applied approach association Basigin BSG Cancer Cardiovascular disorders caused COL-3 Complication contagious contagious disease coronavirus COVID-19 Critical diabetes Diabetic diabetic complications disease downregulate drug Effect entinostat explain fatality Fatality rate Gene Expression host-pathogen interaction human proteins insulin investigated involved lung cancer Lung injury mocetinostat molecular basis network older patient older patients pathway Potential protease Protein protein-protein interaction RAGE random random walk respiratory distress SARS-CoV-2 SARS-CoV-2 proteins Serine serine 2 severe acute respiratory syndrome Coronavirus shown Signaling significantly significantly higher Therapeutics TMPRSS2 transmembrane transmembrane protease serine 2 viral invasion
[DOI] 10.1109/TCBB.2021.3075299 PMC 바로가기 [Article Type] Article

The Unfolded Protein Response and Autophagy on the Crossroads of Coronaviruses Infections

코로나바이러스 감염의 교차로에서 펼쳐진 단백질 반응과 자가포식

Review

Published on 2021-04-282022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] addition autophagy autophagy machinery balance calcium cell death cellular cellular components cellular response Chloroquine component components conserved coronavirus Coronavirus infection CoV debatable debate Degradation drug Each Efficacy Endoplasmic reticulum environmental condition environmental conditions eukaryotic cell eukaryotic cells function functions generate highlighting homeostasis host-pathogen interaction in some include increasingly Infection infections instance integrated stress response involved matter mechanism modulate molecular interaction molecular mechanism molecular mechanisms niclosamide outcome pathway Pathways Perturbation perturbations promote Protein redox status replicative respond response SARS-CoV-2 pandemic signaling pathway spermine Stress suggested Support survival therapeutic options Topic Transcription translation unfolded protein response UPR Vesicle Viral viral infections viral replication virus viruses
[DOI] 10.3389/fcimb.2021.668034 PMC 바로가기 [Article Type] Review

Influence of Hypoxia on the Epithelial-Pathogen Interactions in the Lung: Implications for Respiratory Disease

폐의 상피-병원체 상호작용에 대한 저산소증의 영향: 호흡기 질환에 대한 영향

Review

Published on 2021-03-242022-09-12
Journal: Frontiers in Immunology [Category] SARS, 진단,

[키워드] Activation addition airway airway epithelium Asthma chemokines chronic inflammation chronic obstructive complex COVID-19 Defense disease dysfunction epithelial epithelial cells Evidence fibrosis highlight Host host-pathogen interaction host-pathogen interactions hypoxia hypoxia-inducible factor (HIF)-1 Immunity indicate Infection inflamed tissue Inflammatory inflammatory lung disease influence innate immune response Innate immunity Interaction lung modulating molecular mechanism mucosal normal physiological conditions novel respiratory disease oxygen pathophysiology physical Proinflammatory cytokine Protective provided pulmonary disease receptors Region respiratory Respiratory disease Respiratory pathogens response therapeutic target tissue
[DOI] 10.3389/fimmu.2021.653969 PMC 바로가기 [Article Type] Review

Epigenetic Lens to Visualize the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection in COVID-19 Pandemic

Genetics

Published on 2021-03-222022-10-31
Journal: Frontiers in Genetics [Category] COVID-19,

[키워드] Alter alteration assist association chromatin coronavirus Coronaviruses COVID COVID-19 deaths develop DNA Epidemics Epigenetic epigenetic modulation epigenetics evade Factor Genetic global infection highlight Host host cell host gene expression Host immune response host-pathogen interaction human populations immune response immune sensing Immunopathogenesis Infection interactions interfere intrinsic involved kill knowledge Len mechanism MERS-CoV Methylation miRNA Modification modulate modulated Mortality Non-coding RNAs pandemic Pathogenesis pathway phenotypic prevent disease progression provide regulate Replication researchers respiratory respiratory RNA viruses RNA virus SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARSCoV2 SARSCoV2 pathogenesis Spread the disease treat Treatment Variation virus widespread
[DOI] 10.3389/fgene.2021.581726 PMC 바로가기 [Article Type] Genetics

Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hot Spots, Functional Cross Talk, and Regulatory Interactions in SARS-CoV-2

Research Article

Published on 2021-02-232022-10-29
Journal: mSystems [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome affected affecting Amino acid Analysis angiotensin-converting enzyme 2 Antiviral binding caused clade co-occurrence Combination Comparative Comparative genomics Complete condition conditions contributing to coronavirus coronavirus disease country COVID-19 CpG D614G effective FIVE full-length genome functional annotation Genome Genomics geographical region highlighting host cell host proteins host-pathogen interaction hypoxia inhibiting Interaction membrane Mutation mutational studies MYO5A MYO5B MYO5C network network analysis novel nucleocapsid ORF8 pandemic pathogenicity pathway patients Phylogenomics Phylogeny polymorphism predicted Protein protein stability Proteins provided rate of infection receptor reduction in Region SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 virus screened Severity of infection single nucleotide SNP Spike protein strain Strains structural biology suggested the United State The United States thrombotic TMPRSS2 translation Transmissibility Transmission Treatment Variation Viral protein ZAP
[DOI] 10.1128/mSystems.00030-21 PMC 바로가기 [Article Type] Research Article

Conserved host-pathogen interactions identify novel treatment options in betacoronavirus infections

Research Highlight

Published on 2021-02-102022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 신약개발,

[키워드] Betacoronavirus host-pathogen interaction identify Infection Infectious diseases Treatment
[DOI] 10.1038/s41392-021-00480-z PMC 바로가기 [Article Type] Research Highlight

Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19

심각한 COVID-19 환자를 위한 임상 의사 결정 지원 프로토콜 내에서 염증 조절을 돕는 바이오마커로서의 IP-10의 잠재력에 대한 관찰 코호트 연구

Clinical Trial

Published on 2021-01-122022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, 바이오마커, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Biomarker clinical decision cohort study coronavirus correlated Corticosteroid corticosteroid immunomodulatory therapy COVID-19 patient COVID-19 patients COVID-19-related complications died disease stage disease stages host protein host-pathogen interaction hyperinflammation immune immunoassay immunomodulatory therapy Inflammation intensive care intensive care unit interferon involved IP-10 Lung injury management Mortality Oxygenation Patient performed platform protocol quantitative measurement Registered Regulation respiratory Result severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severely ill COVID-19 patients Severity Score significantly single-center subsequent Support therapeutic utility Viral viral clearance virus-induced hyperinflammation while with COVID-19 γ-induced protein 10
[DOI] 10.1371/journal.pone.0245296 PMC 바로가기 [Article Type] Clinical Trial

Microstructure, pathophysiology, and potential therapeutics of COVID-19: A comprehensive review

COVID-19의 미세구조, 병태생리학 및 잠재적 치료제: 종합 검토

Review

Published on 2021-01-012022-09-12
Journal: Journal of medical virology [Category] MERS, SARS, 진단,

[키워드] 2019-nCoV 2019-nCoV infection ACE2 Affect against SARS-CoV Analysis angiotensin-converting enzyme 2 Antigen coronavirus COVID-19 cross-reactivity death developmental Diagnosis diagnosis of COVID-19 diagnostic disease domain drug Genetic variation genomic gold standard help higher risk HLA host-pathogen interaction individual Infection infections initial leukocyte MERS-CoV Microstructure Morphological Novel coronavirus pathophysiology polymerase chain RBD SARS-CoV sequence similarity serological test Seven severity spread of COVID-19 Stage the antibody the spike protein Trial understanding Vaccine vaccine candidate Variation virus whole protein
[DOI] 10.1002/jmv.26254 PMC 바로가기 [Article Type] Review