Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen16주 간격 BNT162b2 요법에서 강력한 백신 반응성과 B 및 T 세포 면역의 시간적 연관성Article Published on 2022-06-282022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Administered AIM assay Analysis association associations B cell B cell response B cells BNT162b2 BNT162b2 mRNA CD4 CD4 T cell CD4 T cell help CD8 CD8 T cell cellular Clustering cohorts coronavirus COVID-19 CP: Immunology donors dose Efficacy elicit feature first dose functional humoral Humoral response humoral responses immune immune memory Immunity immunological Immunological memory longer interval magnitude memory T mRNA mRNA vaccine of BNT162b2 participant phenotypic raise recall regimen response reveal robust SARS-CoV-2 second dose single-cell spacing spike spike glycoproteins T cell T cell response T helper Temporal Vaccine vaccine regimen. while [DOI] 10.1016/j.celrep.2022.111013 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial6~17세 어린이 대상 ChAdOx1 nCoV-19(AZD1222) 백신의 안전성 및 면역원성: 2상 단일 맹검, 무작위, 대조 시험인 COV006의 예비 보고서Clinical Trial Published on 2022-06-112022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] 95% CI administration Adults adverse event adverse events age All participants anti-SARS-CoV-2 IgG antibody Antibody titre antibody titres arbitrary unit assigned AstraZeneca AZD1222 baseline capsular Cellular responses ChAdOx1 ChAdOx1 nCoV-19 children chronic respiratory conditions Concentration Controlled trial COVID-19 COVID-19 vaccine COVID-19 vaccines Cutoff Department dose doses Efficacy enrolled Fever first dose first vaccination four group four groups geometric geometric mean geometric mean ratios Geometric means group half-maximal inhibitory concentration Humoral response humoral responses immune response immune responses immunogenic immunogenicity in some intramuscular dose introduced investigators ISRCTN Laboratory laboratory-confirmed Laboratory-confirmed COVID-19 Local nucleocapsid protein Pain and tenderness participant Participants peaked Phase 2 phase 3 study preliminary report Primary outcome prime and boost raised randomised Randomly receive receiving recruitment Registered remained reported resolved respiratory response Safety safety population SARS-CoV-2 second dose second vaccination secondary outcome Serious Adverse Event Serious Adverse Events seronegative seronegative participant seronegative participants seropositive serostatus single-blind stratified study drug study groups tenderness Tolerability treatment allocation Trial vaccination Vaccine Viral viral particle were recorded [DOI] 10.1016/S0140-6736(22)00770-X PMC 바로가기 [Article Type] Clinical Trial
Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2전신 중화 항체와 국소 면역 반응은 SARS-CoV-2의 통제에 중요합니다Article Published on 2022-06-102022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administration approved Brain cell-mediated immune response complex Control Correlate of protection COVID-19 COVID-19 vaccines Critical dissemination DNA Efficacy elicited heterologous vaccine humoral humoral responses immune response immunization immunogenic intramuscular intranasal Local lung mucosal mucosal immunity nanovaccine Neutralizing Parenteral Plasmid prevented Protective reduced response SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S serum systemic T-cell immune response transgenic mice used to evaluate Vaccine viral burden viral replication [DOI] 10.3390/v14061262 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular CytotoxicitySARS-CoV-2 액세서리 단백질 ORF8은 항체 의존성 세포 세포 독성을 감소시킵니다Article Published on 2022-06-072022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accessory accessory protein accessory proteins ADCC addition antibody-dependent cellular cytotoxicity bind CD16 CD8+ T cell coronavirus decrease disease evade Fc-mediated effector function help host immune responses humoral responses identify immune evasion monocyte Monocytes mononuclear cell mutate nanomolar affinity Neutralizing antibodies NK cells ORF8 PBMC Peripheral blood Protein reduce reducing SARS-CoV-2 SARS-CoV-2-infected cell significantly spike susceptibility [DOI] 10.3390/v14061237 PMC 바로가기 [Article Type] Article
Cellular and Humoral Immunity to SARS-CoV-2 Infection in Multiple Sclerosis Patients on Ocrelizumab and Other Disease-Modifying Therapies: A Multi-Ethnic Observational StudyOcrelizumab 및 기타 질병 수정 요법을 사용하는 다발성 경화증 환자의 SARS-CoV-2 감염에 대한 세포 및 체액 면역: 다민족 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Annals of neurology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] age ANN antibody Antibody Response Antibody responses assays association Asymptomatic cellular Cellular and humoral immunity Cellular and humoral responses Cellular immune response chemiluminescence immunoassay Clinical course Clinical severity coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 determine domain Effect ELISA ELISPOT ELISpot assays enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence evidence of group Hospitalized humoral Humoral and cellular immune responses Humoral immunity Humoral response humoral responses IFNγ IL-2 immune responses immunoassay immunologic response immunologic responses Infection Laboratory Live virus microneutralization MOST Multiple multiple sclerosis multivariate analyses Multivariate analysis N-terminal domain Natalizumab not differ Ocrelizumab Other Patient performed Protein RBD receptor recruited respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sclerosis Severe acute respiratory syndrome severity Spearman sphingosine spike Spike protein symptomatic infection T-cell Response T-cell responses therapy with COVID-19 [DOI] 10.1002/ana.26346 PMC 바로가기 [Article Type] Observational Study
Anti-SARS-CoV-2 antibody response after 2 and 3 doses of BNT162b2 mRNA vaccine in patients with lymphoid malignancies림프성 악성종양 환자에서 BNT162b2 mRNA 백신 2회 및 3회 투여 후 항-SARS-CoV-2 항체 반응Article Published on 2022-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected anti-CD20 Anti-CD20 antibodies Anti-CD20 antibody anti-CD38 anti-RBD Anti-RBD IgG antibody antibody concentration Antibody concentrations Antibody Response B-cell malignancies B-cell malignancy benefit binding domain booster Cell Cohort Concentration conducted Course COVID-19 COVID-19 patient COVID-19 patients disorders dose effective evaluate haematological malignancies haematological malignancy Haematologicalmalignancies humoral Humoral response humoral responses IgG Immunocompromised increment IQR lymphoid lymphomas malignancies malignancy median monoclonal Mortality mRNA vaccination mRNA vaccine of BNT162b2 Patient patients patients treated plasma Plasma cell Prophylaxis quantification RBD SARS-CoV-2 Seroconversion seroconversion rate seroconverted serological serological response serology significantly spike the disease the vaccine therapy third dose Vaccine vaccine dose [DOI] 10.1016/j.cmi.2022.02.029 PMC 바로가기 [Article Type] Article
Oxidative stress and endogenous DNA damage in blood mononuclear cells may predict anti-SARS-CoV-2 antibody titers after vaccination in older adults혈액 단핵 세포의 산화 스트레스와 내인성 DNA 손상은 노인에서 예방 접종 후 항 SARS-CoV-2 항체 역가를 예측할 수 있습니다Article Published on 2022-06-012022-09-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 치료기술, [키워드] age All participants anti-S anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Anti-spike antibodies antibody Biomarker Biomarkers Blood BNT162b2 circulating correlated DNA DNA damage DNA damage response double-strand break DSBs Efficacy Efficiency first dose genomic humoral immune response Humoral response humoral responses Hypothesis IgG antibodies Immune cell immune cells immune senescence increase in Increased individual inverse correlation mononuclear cell mRNA vaccination neutralizing capacity Older oxidative oxidative stress Participants Peripheral blood Peripheral blood mononuclear cells pre-vaccination predict SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccination second dose Stress tested titers vaccination Vaccine vaccine efficacy [DOI] 10.1016/j.bbadis.2022.166393 PMC 바로가기 [Article Type] Article
Development of SARS-CoV-2 variant protein microarray for profiling humoral immunity in vaccinated subjects백신 접종 대상체의 체액성 면역 프로파일링을 위한 SARS-CoV-2 변이 단백질 마이크로어레이 개발Article Published on 2022-05-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 anti-spike antibody antibody Antibody responses AZD1222 B.1.1.7 B.1.351 B.1.617 B.1.617.1 B.1.617.2 binding ChAdOx1 chimeric collected correlated D614G demonstrated develop development domain Drug development Extracellular globe host receptor Humoral immunity Humoral response humoral responses IgA IgG IgM isotype IgM isotypes immune inhibiting Microarray MONITOR mRNA-1273 mutant neutralization neutralizing activities Neutralizing activity neutralizing antibody P.1 platform Protein protein microarray Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serology serum spike variants subject the antibody response vaccinated individual vaccination Vaccine Vaccines variant variants variants of concern Virus neutralization wild-type [DOI] 10.1016/j.bios.2022.114067 PMC 바로가기 [Article Type] Article
Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity장기 allo-HSCT 생존자에서 백신 접종 후 SARS-CoV-2 T-세포 반응의 결핍은 체액성 면역 감소로 해석됩니다Article Published on 2022-05-102022-09-11 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Amino acid analyzed anti-RBD BNT162b2 Control coronavirus COVID-19 COVID-19 vaccines death deficiency detectable determine disease Ex vivo Fisher Fisher's exact test healthy control hematological Hematopoietic stem cell HSCT Humoral immunity humoral responses IgG immunogenicity Immunoglobulin Immunoglobulin G interferon interferon-γ lack median mRNA mRNA-1273 Odds ratio of BNT162b2 overlap Patient peptide peptides rate of seroconversion RBD reactivity Receptor binding domain recipient recipients reflected respiratory risk S1 IgG SARS-CoV-2 second vaccination Seroconversion seronegative serum severe acute respiratory syndrome Coronavirus severe disease significantly lower stem cell Stem cell transplantation stimulated substandard survivor T-cell T-cell immunity T-cell Response T-cell responses translate transplantation vaccination Vaccinations vaccine dose Whole blood [DOI] 10.1182/bloodadvances.2021006937 PMC 바로가기 [Article Type] Article
Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients일시적인 항대사물질 치료 보류는 신장 이식 수혜자의 SARS-CoV-2 백신 접종에 따른 체액성 및 세포성 면역을 향상시킵니다.Article Published on 2022-05-092022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acquisition antimetabolite treatment applied Arm autoimmune disorder B cell boost booster vaccination caused CD4+ T cell cellular immunity COVID-19 cytokine production dose Frequency humoral humoral immune response humoral responses IgG levels Immunity Immunosuppression IMPROVE increase in kidney transplant recipient kidney transplant recipients memory mounted organ transplantation outcomes Patient patients plasmablasts positively correlated programmed cell death proportion protective immunity recent Receptor binding recipient relative frequency remained revaccination SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly increased T cell temporary Transplant vaccination Vaccinations Vaccines virus-neutralizing [DOI] 10.1172/jci.insight.157836 PMC 바로가기 [Article Type] Article