SARS-CoV-2 infections in mRNA vaccinated individuals are biased for viruses encoding spike E484K and associated with reduced infectious virus loads that correlate with respiratory antiviral IgG levelsmRNA 백신을 접종한 개인의 SARS-CoV-2 감염은 스파이크 E484K를 인코딩하는 바이러스에 대해 편향되어 있으며 호흡기 항바이러스성 IgG 수준과 상관관계가 있는 감소된 감염성 바이러스 부하와 관련이 있습니다.Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] A significant reduction accompanied Alpha Alpha variant Amino acid Analysis Anti-viral Antiviral association B.1.1.7 B.1.526 BNT162b2 Breakthrough infection breakthrough infections caused Cell culture change Cohort collected COVID-19 cycle threshold dose E484K early phase ELISA examined Genome ICU admission IgG IgG level IgG levels immunization increase in Infectious virus investigated Lineage Moderna molecular Mortality mRNA mRNA-1273 PCR Pfizer-BioNTech positive positive sample Positive test predominant Protein reduce reduced required respiratory respiratory sample Respiratory samples Sample SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 positive patient sequenced Sequencing specimen specimens spike Spike protein symptomatic infection symptomatic infections upper respiratory tract vaccinated individual vaccinated individuals vaccination Vaccines variant Viral Viral load viral loads viral variant virus were used whole genome [DOI] 10.1016/j.jcv.2022.105151 PMC 바로가기 [Article Type] Article
Receptor binding domain-IgG levels correlate with protection in residents facing SARS-CoV-2 B.1.1.7 outbreaks수용체 결합 도메인-IgG 수준은 SARS-CoV-2 B.1.1.7 발병에 직면한 거주자의 보호와 상관관계가 있습니다.Article Published on 2022-06-012022-09-11 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] antibody Antibody Response antigenemia association B.1.1.7 binding BNT162b2 BNT162b2 vaccine Chain Reaction COVID-19 death domain dose Efficacy humoral IgG levels in vitro incidence information Limited Nasopharyngeal swab nasopharyngeal swab test Neutralizing Neutralizing antibodies nucleocapsid nucleocapsid antigenemia nursing home nursing homes outbreak polymerase chain polymerase chain reaction positive Post-vaccine qPCR RBD reduction residents reverse-transcriptase polymerase chain reaction risk risk factor RT-qPCR S1 subunit SARS-CoV-2 SARS-CoV-2 B.1.1.7 Serum Neutralization Serum neutralizing antibody Seven severe COVID-19 severe symptoms Symptom Symptoms tested the S1 subunit Vaccine was measured [DOI] 10.1111/all.15142 PMC 바로가기 [Article Type] Article
Vaccination with BNT162b2 and ChAdOx1 nCoV-19 Induces Cross-Reactive Anti-RBD IgG against SARS-CoV-2 Variants including OmicronBNT162b2 및 ChAdOx1 nCoV-19 백신 접종은 Omicron을 포함한 SARS-CoV-2 변이체에 대한 교차 반응성 항-RBD IgG를 유도합니다Article Published on 2022-05-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] adaptive Adaptive immunity age Alpha Alpha variant anti-RBD BNT162b2 booster vaccinations Breakthrough infection breakthrough infections caused ChAdOx1 ChAdOx1 nCoV-19 Cohort contribute Course COVID-19 cross-reactive cross-reactive antibodies cross-reactivity Delta delta variant domain ELISA explain Gamma health-care IgG IgG ELISA IgG level IgG levels Immunity independent independent of individual Infection infection rate lethality magnitude morbidity nucleocapsid nucleocapsid IgG omicron Omicron variants RBD RBD IgG reactivity Receptor-binding domain Receptor-binding domain (RBD) recipient SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variants sera Sex significant increase significantly higher significantly lower Spike protein Spread tested the spike protein university vaccination vaccination rate Vaccine variants variants of concern Vienna VoC VOCs was increased while [DOI] 10.3390/v14061181 PMC 바로가기 [Article Type] Article
Seroconversion to mRNA SARS-CoV-2 Vaccines in Hematologic Patients혈액학적 환자에서 mRNA SARS-CoV-2 백신으로의 혈청전환Article Published on 2022-05-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI acute leukemia acute myeloid leukemia Algorithm Analysis Anti-spike BNT162b2 chronic lymphocytic leukemia CLL COVID-19 Diagnosis disorders hematologic IgG IgG level IgG levels indolent Italy lack leukemia Lymphocytic leukemia lymphoma Moderna monoclonal antibodies mRNA mRNA vaccination mRNA-1273 Multiple myeloma multivariable analysis myelofibrosis myeloproliferative disorders myeloproliferative disorders. Neoplasms normal range Patient patients Pfizer Pfizer-BioNTech predict predictor prospective cohort study receiving response risk factor ruxolitinib SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seroconversion seroconverted simple algorithm single center small molecule Small molecules therapy treated Treatment vaccine administration vaccine dose venetoclax [DOI] 10.3389/fimmu.2022.852158 PMC 바로가기 [Article Type] Article
Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients일시적인 항대사물질 치료 보류는 신장 이식 수혜자의 SARS-CoV-2 백신 접종에 따른 체액성 및 세포성 면역을 향상시킵니다.Article Published on 2022-05-092022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acquisition antimetabolite treatment applied Arm autoimmune disorder B cell boost booster vaccination caused CD4+ T cell cellular immunity COVID-19 cytokine production dose Frequency humoral humoral immune response humoral responses IgG levels Immunity Immunosuppression IMPROVE increase in kidney transplant recipient kidney transplant recipients memory mounted organ transplantation outcomes Patient patients plasmablasts positively correlated programmed cell death proportion protective immunity recent Receptor binding recipient relative frequency remained revaccination SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly increased T cell temporary Transplant vaccination Vaccinations Vaccines virus-neutralizing [DOI] 10.1172/jci.insight.157836 PMC 바로가기 [Article Type] Article
COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutantsCOVID-19 환자 혈청은 다양한 SARS-CoV-2 RBD 돌연변이에 대한 ACE2-RBD 결합을 덜 강력하게 억제합니다Article Published on 2022-05-032022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 binding ACE2 receptor ACE2-RBD ACE2-RBD binding Affect Analysis analyzed antibody bead binding classical correlated COVID-19 patient COVID-19 patient serum disease severity displaying E484K E484K mutation examined extension IgG levels immune protection increasingly Infectious virus inhibit Interaction less Longevity mimicking multiplex Multiplex assay mutant NAbs neutralization test neutralization tests Neutralizing activity Neutralizing antibodies positively correlated proceed protective immunity RBD RBDs Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants serological serum sample serum samples severity the RBD therapy vaccination variant variants variants of interest virus neutralization test VoC VOCs VOIs was reduced WHO wild-type [DOI] 10.1038/s41598-022-10987-2 PMC 바로가기 [Article Type] Article
Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection전신 및 점막 IgA 반응은 SARS-CoV-2 mRNA 백신 접종에 대한 반응으로 다양하게 유도되며 후속 감염에 대한 보호와 관련이 있습니다.Article Published on 2022-05-012022-09-11 Journal: Mucosal Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] anti-SARS-CoV-2 Anti-spike booster Breakthrough infection breakthrough infections collected comparable COVID-19 COVID-19 mRNA Vaccination COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines dose elicit Examining exhibited groups IgA IgA response IgG IgG level IgG levels in some infect infected with SARS-CoV-2 Infection Kinetics kinetics of antibody Local mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA vaccination mucosal IgA response oral cavity participant Participants persist positive preventing infection prospective cohort provoke RBD RBD IgA receiving reduce respiratory Saliva SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second dose serum subsequent systemic These data Transmission upper respiratory tract utility [DOI] 10.1038/s41385-022-00511-0 PMC 바로가기 [Article Type] Article
Strong Decay of SARS-CoV-2 Spike Antibodies after 2 BNT162b2 Vaccine Doses and High Antibody Response to a Third Dose in Nursing Home Residents요양원 거주자의 2회 BNT162b2 백신 접종 후 SARS-CoV-2 스파이크 항체의 강한 붕괴와 세 번째 접종에 대한 높은 항체 반응Article Published on 2022-05-012022-09-11 Journal: Journal of the American Medical Directors Associat [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Abbott Abbott Diagnostics Administered antibody Antibody Response average B.1.1.529 BAU BNT162b2 BNT162b2 vaccine boost boost vaccine dose Chain Reaction cohort study COVID-19 decay domain dose home IgG IgG levels less median Nasopharyngeal swab nucleocapsid Nursing nursing home nursing home residents nursing homes other variant other variants polymerase chain polymerase chain reaction positive provided Quantitative resident response reverse transcription SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike antibodies second dose setting slope spike Strong the antibody response vaccination Vaccine vaccine dose were measured [DOI] 10.1016/j.jamda.2022.02.006 PMC 바로가기 [Article Type] Article
Are SARS-CoV-2 Antibodies Detectable in Human Milk After Vaccination Against COVID-19?COVID-19 백신 접종 후 SARS-CoV-2 항체가 모유에서 검출될 수 있습니까?Article Published on 2022-04-302022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Against analyzed anti-SARS-CoV-2 antibody Antibody titers Antibody Units association authors benefit binding antibody unit binding antibody units BNT162b2 BNT162b2 mRNA Breastfeeding children Clinical outcome Concentration conducted control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine domain dose Effectiveness evaluated Factors gold gold standard HCW HCWs healthcare worker Human human milk IgA IgG IgG level IgG levels IgM immune response immune responses Immunity immunization Immunoglobulin immunoglobulin A Immunoglobulin G immunoglobulin M in vitro include independent ineligible Infant Infants Infection Influenza lack lactation limitation linear milk mother mRNA mRNA COVID-19 vaccines mRNA-1273 Multiple regression neutralization tests Neutralizing antibody titer neutralizing antibody titers nucleocapsid protein nutrition pandemic participant Participants plaque reduction neutralization positive correlation predicted Prospective Study Protein receipt receiving recipient reported Research respiratory S1 IgG SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody serology serum subgroup analysis Support transfer vaccination Vaccines was performed women [DOI] 10.1093/jpids/piac024 PMC 바로가기 [Article Type] Article
Differences in Humoral and Cellular Vaccine Responses to SARS-CoV-2 in Kidney and Liver Transplant Recipients신장 및 간 이식 환자의 SARS-CoV-2에 대한 체액 및 세포 백신 반응의 차이Article Published on 2022-04-142022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] adjust antibody Antibody Response Antigen blood sample cells coronavirus Coronaviruses COVID-19 difference elicit epitope Epitopes explained Generalized linear model groups IgG level IgG levels Immunosuppression kidney kidney transplant recipient kidney transplant recipients liver liver transplant mRNA Multiplex assay multivariable not affect nucleocapsid phenomenon quantified reactive recipient recipients remained response SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 variants significantly lower significantly more Spike protein statistical significance T cell T cell response T cell responses T cells tested Transplant variant Wuhan strain [DOI] 10.3389/fimmu.2022.853682 PMC 바로가기 [Article Type] Article